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The map label for this gene is cyaA [H]

Identifier: 238025055

GI number: 238025055

Start: 2145559

End: 2147574

Strand: Reverse

Name: cyaA [H]

Synonym: bglu_2g17110

Alternate gene names: 238025055

Gene position: 2147574-2145559 (Counterclockwise)

Preceding gene: 238025056

Following gene: 238025054

Centisome position: 75.96

GC content: 62.7

Gene sequence:

>2016_bases
ATGTTCGGAAAACTTACACTCGACGCGATTCCGTATCACGAGCCGATCCTCGTGGTCACGGCGCTCGGCGTCGGCATCAT
GGGGGCCCTGGTGCTGGGTCTCGTCACTTACTTCGGTAAGTGGAAATATCTCTGGACCGAGTGGCTGACGAGCGTCGACC
ACAAGCGTCTCGGCGTGATGTACATCGCCGTTGCCCTCGTCATGCTGCTGCGCGGCTTCGCCGACGCGATCATGATGCGT
ACCCAGCTCGCGCTGGCGTACAACGCGCCGGGCTACCTGCCGCCGCACCACTACGACCAGATCTTCACCGCGCACGGCGT
CATCATGATCTTCTTCATGGCGATGGCGTTCATGGTGGGTCTGATGAACCTGGTGGTGCCGCTGCAGATCGGCGCGCGCG
ACGTGGCGTTCCCGTTCCTGAACTCGCTGTCGTTCTGGATGACGGCGGTGGGCGCGATCCTGCTGATGATCTCGCTGTTC
ATCGGCGAATTCGCGCAGACCGGCTGGCTCGCGTACCCGCCGCTCTCGGAGCTGGCCTATAGTCCAGGGGTAGGGGTCGA
CTACTACATCTGGGCGCTGCAGATCTCCGGGGTGGGCACGCTGCTGACCGGCGTGAACTTCTTCGTGACCATCATCAAGA
TGCGCGCGCCGGGCATGACGCTGATGAAGATGCCCGTGTTCACCTGGACGGCGCTCTGCACCAACGTGCTGATCATGGCG
GCGTTCCCGATCCTGACCGTCACGCTCGCGCTGCTCGGCCTCGACCGTTATCTGGGGATGCACTTCTTCACCAATGACGG
CGGCGGCAACGTCATGATGTACCTGAACCTGATCTGGGCCTGGGGTCACCCCGAGGTGTACATCCTGATCCTGCCGGCGT
TCGGCGTGTTCTCGGAAGTCGTGGCGACCTACGCGAAGAAGCCGCTGTTCGGCTACAAGACGATGGTCTACGCCACCTGC
GCGATCATGGTCCTGTCGTTCCTCGTGTGGCTGCACCACTTCTTCACGATGGGCTCGGGCGCCGACGTCAATGCGTTCTT
CGGCATCGCCACGATGATCATCGCGATCCCGACCGGCGTGAAGATCTTCAACTGGCTGTTTACGATCTACCGTGGCCGCC
TGGAGTTCAGCGCGCCGATCCTCTGGACGCTCGGCTTCATGGTCACGTTCACGGTGGGCGGCATGACCGGCGTGATGATG
GCGATCCCGGGCGCGGACTTCGTGCTGCATAACAGCCTGTTCCTGATCGCCCACTTCCACAACGTGATCATCGGCGGCGT
GCTGTTCGGCTATCTGGCGGGCTTCAACTACTGGTTCCCGAAGGTGTTCGGCTTCAAGCTCAACGAGAAGCTCGGCAAGC
GCGCGTTCTGGTTCTGGCAGCTCGGCTTCATCTTCGCCTTCACGCCGCTGTACGTGCTCGGCTTCATGGGCGTGACGCGT
CGTCTGAACCACTACGACAACCCCGCATGGCATCCGTGGATGGAAGTCGCGCTGTTCGGCGCGGTGCTGGTGCTGATCGG
CATCGTTCACCAGCTGCTGCAGCTGTACGTGTCGATCCGCGACCGCAACCTGCCGGGCAACCGTGACCTGACGGGCGACC
CGTGGAACGGCCACACGCTCGAGTGGGCGACGTCCTCGCCGCCGGCGCCGTACAACTTCGCGATCATCCCGACGATCCAC
GAGCTCGACGAAGTGTCGTATCGCAAGGAGCGCGGCCTCGGCTTCGGTCTGGAGAAGGGCCAGCAGTACGAGGACATCCA
CATGCCCTCGAACACCAGCGCGGGCTTCTTCATCGGCATGTTCTCGCTGGTGCTCGGCTTTGCCGGCGTCTGGCACATCT
GGTGGCTGGCCATCGTCGGCTTCGTCGGCATCGTTGCGACCGCGATCATCTACAGCTCGCAGAAGAACGAGGGCTACTAC
ATTCCGGCCGACACGGTGCGGAAGATCGAAGAGCAGCGTGGTGGTGCGCGTGTCGCGGCACCGCGTCCTGCTGCAGTGGA
ACTGGAGGCCAACTGA

Upstream 100 bases:

>100_bases
CCGTCGATCCGCGCCTGTTCAATAACATCGTTGGCAAGTACAACAACGGCCACGTCATGGAATTCAATGACGCGTCGTGC
AGTACGACGAAGGGGTAAGC

Downstream 100 bases:

>100_bases
TGGCACAAAGCACCCTGACTGCCGATCACCATCACGCGGCAGAGCATCACCATCCGCCGTCGCATTCGGTGTTCGGCTTC
TGGCTGTACCTGATGACCGA

Product: Ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MFGKLTLDAIPYHEPILVVTALGVGIMGALVLGLVTYFGKWKYLWTEWLTSVDHKRLGVMYIAVALVMLLRGFADAIMMR
TQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMAFMVGLMNLVVPLQIGARDVAFPFLNSLSFWMTAVGAILLMISLF
IGEFAQTGWLAYPPLSELAYSPGVGVDYYIWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
AFPILTVTLALLGLDRYLGMHFFTNDGGGNVMMYLNLIWAWGHPEVYILILPAFGVFSEVVATYAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGADVNAFFGIATMIIAIPTGVKIFNWLFTIYRGRLEFSAPILWTLGFMVTFTVGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKVFGFKLNEKLGKRAFWFWQLGFIFAFTPLYVLGFMGVTR
RLNHYDNPAWHPWMEVALFGAVLVLIGIVHQLLQLYVSIRDRNLPGNRDLTGDPWNGHTLEWATSSPPAPYNFAIIPTIH
ELDEVSYRKERGLGFGLEKGQQYEDIHMPSNTSAGFFIGMFSLVLGFAGVWHIWWLAIVGFVGIVATAIIYSSQKNEGYY
IPADTVRKIEEQRGGARVAAPRPAAVELEAN

Sequences:

>Translated_671_residues
MFGKLTLDAIPYHEPILVVTALGVGIMGALVLGLVTYFGKWKYLWTEWLTSVDHKRLGVMYIAVALVMLLRGFADAIMMR
TQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMAFMVGLMNLVVPLQIGARDVAFPFLNSLSFWMTAVGAILLMISLF
IGEFAQTGWLAYPPLSELAYSPGVGVDYYIWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
AFPILTVTLALLGLDRYLGMHFFTNDGGGNVMMYLNLIWAWGHPEVYILILPAFGVFSEVVATYAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGADVNAFFGIATMIIAIPTGVKIFNWLFTIYRGRLEFSAPILWTLGFMVTFTVGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKVFGFKLNEKLGKRAFWFWQLGFIFAFTPLYVLGFMGVTR
RLNHYDNPAWHPWMEVALFGAVLVLIGIVHQLLQLYVSIRDRNLPGNRDLTGDPWNGHTLEWATSSPPAPYNFAIIPTIH
ELDEVSYRKERGLGFGLEKGQQYEDIHMPSNTSAGFFIGMFSLVLGFAGVWHIWWLAIVGFVGIVATAIIYSSQKNEGYY
IPADTVRKIEEQRGGARVAAPRPAAVELEAN
>Mature_671_residues
MFGKLTLDAIPYHEPILVVTALGVGIMGALVLGLVTYFGKWKYLWTEWLTSVDHKRLGVMYIAVALVMLLRGFADAIMMR
TQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMAFMVGLMNLVVPLQIGARDVAFPFLNSLSFWMTAVGAILLMISLF
IGEFAQTGWLAYPPLSELAYSPGVGVDYYIWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
AFPILTVTLALLGLDRYLGMHFFTNDGGGNVMMYLNLIWAWGHPEVYILILPAFGVFSEVVATYAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGADVNAFFGIATMIIAIPTGVKIFNWLFTIYRGRLEFSAPILWTLGFMVTFTVGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKVFGFKLNEKLGKRAFWFWQLGFIFAFTPLYVLGFMGVTR
RLNHYDNPAWHPWMEVALFGAVLVLIGIVHQLLQLYVSIRDRNLPGNRDLTGDPWNGHTLEWATSSPPAPYNFAIIPTIH
ELDEVSYRKERGLGFGLEKGQQYEDIHMPSNTSAGFFIGMFSLVLGFAGVWHIWWLAIVGFVGIVATAIIYSSQKNEGYY
IPADTVRKIEEQRGGARVAAPRPAAVELEAN

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=526, Percent_Identity=38.9733840304183, Blast_Score=335, Evalue=9e-92,
Organism=Escherichia coli, GI1786634, Length=654, Percent_Identity=69.5718654434251, Blast_Score=942, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=529, Percent_Identity=37.9962192816635, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=44, Blast_Score=259, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6226523, Length=245, Percent_Identity=34.6938775510204, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74922; Mature: 74922

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLDAIPYHEPILVVTALGVGIMGALVLGLVTYFGKWKYLWTEWLTSVDHKRLGVM
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
YIAVALVMLLRGFADAIMMRTQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMAFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLVVPLQIGARDVAFPFLNSLSFWMTAVGAILLMISLFIGEFAQTGWLAYPPLSELAY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
SPGVGVDYYIWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AFPILTVTLALLGLDRYLGMHFFTNDGGGNVMMYLNLIWAWGHPEVYILILPAFGVFSEV
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEHEECCCCCEEEEEECCHHHHHHH
VATYAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGADVNAFFGIATMIIAIPTGV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTIYRGRLEFSAPILWTLGFMVTFTVGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKVFGFKLNEKLGKRAFWFWQLGFIFAFTPLYVLGFMGVTR
HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWMEVALFGAVLVLIGIVHQLLQLYVSIRDRNLPGNRDLTGDPWNGHTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATSSPPAPYNFAIIPTIHELDEVSYRKERGLGFGLEKGQQYEDIHMPSNTSAGFFIGM
EECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FSLVLGFAGVWHIWWLAIVGFVGIVATAIIYSSQKNEGYYIPADTVRKIEEQRGGARVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCEEEC
PRPAAVELEAN
CCCCEEEEECC
>Mature Secondary Structure
MFGKLTLDAIPYHEPILVVTALGVGIMGALVLGLVTYFGKWKYLWTEWLTSVDHKRLGVM
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
YIAVALVMLLRGFADAIMMRTQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMAFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLVVPLQIGARDVAFPFLNSLSFWMTAVGAILLMISLFIGEFAQTGWLAYPPLSELAY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
SPGVGVDYYIWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AFPILTVTLALLGLDRYLGMHFFTNDGGGNVMMYLNLIWAWGHPEVYILILPAFGVFSEV
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEHEECCCCCEEEEEECCHHHHHHH
VATYAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGADVNAFFGIATMIIAIPTGV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTIYRGRLEFSAPILWTLGFMVTFTVGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKVFGFKLNEKLGKRAFWFWQLGFIFAFTPLYVLGFMGVTR
HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWMEVALFGAVLVLIGIVHQLLQLYVSIRDRNLPGNRDLTGDPWNGHTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATSSPPAPYNFAIIPTIHELDEVSYRKERGLGFGLEKGQQYEDIHMPSNTSAGFFIGM
EECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FSLVLGFAGVWHIWWLAIVGFVGIVATAIIYSSQKNEGYYIPADTVRKIEEQRGGARVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCEEEC
PRPAAVELEAN
CCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]