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The map label for this gene is tcyB [H]

Identifier: 238024847

GI number: 238024847

Start: 1891329

End: 1892015

Strand: Direct

Name: tcyB [H]

Synonym: bglu_2g14870

Alternate gene names: 238024847

Gene position: 1891329-1892015 (Clockwise)

Preceding gene: 238024846

Following gene: 238024848

Centisome position: 66.89

GC content: 72.05

Gene sequence:

>687_bases
ATGACCTACCAGCTCCAGTTCGGCGAACTCGCCGACTATGCCGGCCTGTTCGCGAGCGGCGCGGCCACCACGCTCGCGCT
GACGGCCGTGTCCACCGTGCTCGGCATCGGCATCGGCGTGCTCGGCGCGGCCGCGCAGGACACGCGCGCGCCGCGCCTCG
CGCCGCTGCGCGGCCTGATCGGGGCCTACGTCGAGGCGGTCCGCAACACCCCGTTCCTGGTGCAGCTGTTCTTCGTGTTC
TTCGGCCTGCCCGCGCTCGGCATCCACATCGGCGAGGTGACGGCCGCGATTCTGGCGATGACGCTGAACCTGGGCGCCTA
TTCGGTCGAGATCGTGCGCGCCGGCGTGGCCGCGGTGCCGCGCGGCCACCACGAGGCGGCCGCCGCGCTCGCGCTGTCGC
GCGCCCAGGCGTGGTGCCACGTGGTGCTGCCGCAGGCGCTCGCCAAGGTGTTCCCGGCGCTCGTCAGCCAGATCGTGATC
ACGCTGCTCGGCTCGGCGGTGGTCTCGCAAATTTCGGTGGCCGACCTGACCTACGCGGCCGGCTATATCCAGTCGCGCAA
CTTCCGCGCGTTCGAGACGTACTTCGTGATCACGCTCGCCTATCTCGCGATGGCGCTGCTGCTGCGCGCGGCGCTCAACA
CGGCGGGCCGCCGGCTGTTCGCGCGCGGCGCGGGAGGCGCGCGATGA

Upstream 100 bases:

>100_bases
ACGCTCGACGCGATCTCGAAGAAGTGGCTGGGCCAGCCGCTGCCGGCCGGCCTGTGATGCCGCGCTCGTCCCCGAAACAG
TCCTTCCACCGGCTTCCGAG

Downstream 100 bases:

>100_bases
TCGAGTTCACGTTCGGGCAGATCCTCGCCAACCTGCTGCTCGCGGCGCGCTGGACGGTGCAGCTCTCGCTCGTCTCGTTC
GCGCTCGGCGGCACGCTCGC

Product: Polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTYQLQFGELADYAGLFASGAATTLALTAVSTVLGIGIGVLGAAAQDTRAPRLAPLRGLIGAYVEAVRNTPFLVQLFFVF
FGLPALGIHIGEVTAAILAMTLNLGAYSVEIVRAGVAAVPRGHHEAAAALALSRAQAWCHVVLPQALAKVFPALVSQIVI
TLLGSAVVSQISVADLTYAAGYIQSRNFRAFETYFVITLAYLAMALLLRAALNTAGRRLFARGAGGAR

Sequences:

>Translated_228_residues
MTYQLQFGELADYAGLFASGAATTLALTAVSTVLGIGIGVLGAAAQDTRAPRLAPLRGLIGAYVEAVRNTPFLVQLFFVF
FGLPALGIHIGEVTAAILAMTLNLGAYSVEIVRAGVAAVPRGHHEAAAALALSRAQAWCHVVLPQALAKVFPALVSQIVI
TLLGSAVVSQISVADLTYAAGYIQSRNFRAFETYFVITLAYLAMALLLRAALNTAGRRLFARGAGGAR
>Mature_227_residues
TYQLQFGELADYAGLFASGAATTLALTAVSTVLGIGIGVLGAAAQDTRAPRLAPLRGLIGAYVEAVRNTPFLVQLFFVFF
GLPALGIHIGEVTAAILAMTLNLGAYSVEIVRAGVAAVPRGHHEAAAALALSRAQAWCHVVLPQALAKVFPALVSQIVIT
LLGSAVVSQISVADLTYAAGYIQSRNFRAFETYFVITLAYLAMALLLRAALNTAGRRLFARGAGGAR

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787030, Length=218, Percent_Identity=32.5688073394495, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788226, Length=202, Percent_Identity=29.7029702970297, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1786874, Length=238, Percent_Identity=28.1512605042017, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788646, Length=220, Percent_Identity=28.1818181818182, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1786873, Length=213, Percent_Identity=27.2300469483568, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994930, Length=161, Percent_Identity=31.6770186335404, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788645, Length=210, Percent_Identity=28.0952380952381, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082239, Length=176, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787087, Length=225, Percent_Identity=26.2222222222222, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787086, Length=221, Percent_Identity=23.5294117647059, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 23773; Mature: 23642

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQLQFGELADYAGLFASGAATTLALTAVSTVLGIGIGVLGAAAQDTRAPRLAPLRGLI
CCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHH
GAYVEAVRNTPFLVQLFFVFFGLPALGIHIGEVTAAILAMTLNLGAYSVEIVRAGVAAVP
HHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
RGHHEAAAALALSRAQAWCHVVLPQALAKVFPALVSQIVITLLGSAVVSQISVADLTYAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYIQSRNFRAFETYFVITLAYLAMALLLRAALNTAGRRLFARGAGGAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TYQLQFGELADYAGLFASGAATTLALTAVSTVLGIGIGVLGAAAQDTRAPRLAPLRGLI
CEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHH
GAYVEAVRNTPFLVQLFFVFFGLPALGIHIGEVTAAILAMTLNLGAYSVEIVRAGVAAVP
HHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
RGHHEAAAALALSRAQAWCHVVLPQALAKVFPALVSQIVITLLGSAVVSQISVADLTYAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYIQSRNFRAFETYFVITLAYLAMALLLRAALNTAGRRLFARGAGGAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]