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The map label for this gene is cobB [H]

Identifier: 238024836

GI number: 238024836

Start: 1877100

End: 1877846

Strand: Reverse

Name: cobB [H]

Synonym: bglu_2g14760

Alternate gene names: 238024836

Gene position: 1877846-1877100 (Counterclockwise)

Preceding gene: 238024837

Following gene: 238024835

Centisome position: 66.42

GC content: 69.08

Gene sequence:

>747_bases
ATGATGTCGTCCGTATCGCATGGCCGGCCGCCGCGGCTCTACGTGTTCTCGGGGGCGGGGCTGTCCGCCGAGAGCGGGAT
TCCCACCTTCCGCACCGGCGACGGGATCTGGTCCAGCGCCAATCTCGACAAGGTCTGCAACTTCCTCACCTGGCGCCGCA
ACCGCGAGGCCGTGTTCGCGTTCTACAACGCGCGGATCGCCGAAAAGCGCGAGGCCCGCCCGAACGACGCGCACCGCATG
CTGGCCGCCTGGCAGGAGGCCTGGGGCACCGAACGGGTGCGGCTCGTCACGCAGAATATCGACGATCTGCTGGAGCGGGC
GGGCGCGCGGCAGGTCGTGCATCTGCACGGCGACGTGCATTCGCTGCTCTGCACCGCCTGCGATTGCCGCTTCCCGAAGG
ACGGCGAGCATTACCGGCTCGACACCGCCTGCCCGGCATGCGGCGATGTCGAGTCGGTCAAGCCGGGCGTGGTGTTCTTC
AACGAGGCCGCGCCCGAATACGTGACGCTGCACCGGATGCAGCTCGAGATGACCGAGCGCGACCTGTTCGTGGCGATCGG
CACCGCGTTCCAGGTGGTCGGGCCGGAGAGCCTGCTGCCGCGTGAGCGGCGCCTTCGCCACGCGCGCAACTTCCTGGTCG
ATCCGCAGCCGAGCCGCCCGGAATGCTTCGGCCACGTCGAGGCGGTCTCGGCCAGCGTCGGGCTGCGGAATTTGCAGGCG
CGCATCGAGGCCTTGATGGCCGAGTGA

Upstream 100 bases:

>100_bases
CGCGCGCCGCAACGTCGGCGTTCGCACCCATCCTACAATGTCGGCGCCGGGACGCGCGCCGCTGCCCGGCGCCCGACCGC
TTTTTTTCACCGGAGAATGG

Downstream 100 bases:

>100_bases
TCCGGGGCGGCGCCGCGCCGGCCCGCGCGGCCTGGCATTTTTTCCTTTTCCCGCGCGCCGCTTCCGGCGAGTTTCCCTTA
TCCTGAAACCTTTCCGATGG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MMSSVSHGRPPRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFAFYNARIAEKREARPNDAHRM
LAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVHSLLCTACDCRFPKDGEHYRLDTACPACGDVESVKPGVVFF
NEAAPEYVTLHRMQLEMTERDLFVAIGTAFQVVGPESLLPRERRLRHARNFLVDPQPSRPECFGHVEAVSASVGLRNLQA
RIEALMAE

Sequences:

>Translated_248_residues
MMSSVSHGRPPRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFAFYNARIAEKREARPNDAHRM
LAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVHSLLCTACDCRFPKDGEHYRLDTACPACGDVESVKPGVVFF
NEAAPEYVTLHRMQLEMTERDLFVAIGTAFQVVGPESLLPRERRLRHARNFLVDPQPSRPECFGHVEAVSASVGLRNLQA
RIEALMAE
>Mature_248_residues
MMSSVSHGRPPRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFAFYNARIAEKREARPNDAHRM
LAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVHSLLCTACDCRFPKDGEHYRLDTACPACGDVESVKPGVVFF
NEAAPEYVTLHRMQLEMTERDLFVAIGTAFQVVGPESLLPRERRLRHARNFLVDPQPSRPECFGHVEAVSASVGLRNLQA
RIEALMAE

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=199, Percent_Identity=31.6582914572864, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13787215, Length=217, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI6912664, Length=217, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI6912660, Length=197, Percent_Identity=35.0253807106599, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI63054862, Length=191, Percent_Identity=35.0785340314136, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7657575, Length=207, Percent_Identity=29.4685990338164, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI308199517, Length=211, Percent_Identity=36.9668246445498, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17541892, Length=200, Percent_Identity=31, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567771, Length=152, Percent_Identity=29.6052631578947, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990482, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71990487, Length=265, Percent_Identity=25.6603773584906, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324599, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571445, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137536, Length=218, Percent_Identity=27.9816513761468, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27832; Mature: 27832

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSVSHGRPPRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFA
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEE
FYNARIAEKREARPNDAHRMLAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVH
EEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEEECCHHH
SLLCTACDCRFPKDGEHYRLDTACPACGDVESVKPGVVFFNEAAPEYVTLHRMQLEMTER
HHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCC
DLFVAIGTAFQVVGPESLLPRERRLRHARNFLVDPQPSRPECFGHVEAVSASVGLRNLQA
EEEEEECCEEEEECCHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RIEALMAE
HHHHHHCC
>Mature Secondary Structure
MMSSVSHGRPPRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFA
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEE
FYNARIAEKREARPNDAHRMLAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVH
EEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEEECCHHH
SLLCTACDCRFPKDGEHYRLDTACPACGDVESVKPGVVFFNEAAPEYVTLHRMQLEMTER
HHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCC
DLFVAIGTAFQVVGPESLLPRERRLRHARNFLVDPQPSRPECFGHVEAVSASVGLRNLQA
EEEEEECCEEEEECCHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RIEALMAE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954 [H]