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The map label for this gene is aroP [H]

Identifier: 238024638

GI number: 238024638

Start: 1605471

End: 1606859

Strand: Reverse

Name: aroP [H]

Synonym: bglu_2g12530

Alternate gene names: 238024638

Gene position: 1606859-1605471 (Counterclockwise)

Preceding gene: 238024649

Following gene: 238024637

Centisome position: 56.83

GC content: 66.45

Gene sequence:

>1389_bases
ATGGTTGAACCAACAGAGAACGACAACGGCGGCCTGAAACGCGGGCTCAAGAATCGCCACATCCAACTGATCGCGCTGGG
CGGCGCGATCGGCACGGGACTTTTCCTCGGCATCGCGCAGACCATCCAGACGGCCGGGCCGGCCGTGCTGCTCGGCTACG
CGCTGGGCGGCATCATCGCGTTCTTCATCATGCGGCAACTGGGCGAGATGGTGGTCGACGAGCCCGTCGCCGGCTCGTTC
AGCTACTTCGCCGACAAATACTGCGGACACTTCACGGGCTTCCTGTCCGGCTGGAACTACTGGGTGCTGTACATCCTGGT
CAGCATGGCCGAGCTGTCGGCGGTCGGCATCTACGTGCAGTACTGGTGGCCGGGCGTGCCCACCTGGGTGTCGGCGCTGG
TGTTCTTCGCGCTGATCAACCTGCTCAACGTGGTCAGCGTGAAGTCCTACGGCGAGACCGAGTTCTGGTTCGCGATCGTC
AAGGTGGCCGCCGTGGTCGGCATGATCGGCTTCGGCGCGTGGCTGCTGCTGTCGGGCGGCGCGGGGCCGCAGGCGGGCGT
GGCCAACCTCTGGCGCAACGGCGGCTTCTTCCCGAACGGCGTGGGCGGCCTCGTCAGCTCGATGGCGGTCATCATGTTCT
CGTTCGGCGGGCTCGAACTGGTGGGCATCACGGCCGCCGAGGCCGACGATCCCACCCGCAGCATTCCGCGCGCGACCAAC
CAGGTGATCTACCGCATCCTGATTTTCTACATCGGCGCGCTGGGCGTGCTGCTCTCGCTGTTTCCGTGGCAGAAGGTGGT
CACGGGCGGCAGCCCGTTCGTGCTGATCTTCCGTGCGCTCGGCAGCGACCTGGTGGCGGACGTGCTGAACGTGGTGGTGC
TGACGGCCGCGCTGTCGGTCTACAACAGCGGCGTGTACTGCAACAGCCGCATGCTGTTCGGCCTCGCGCAGCAGGGCAAC
GCGCCGCGTGCGCTGCTGTCGGTGAGCCGGCGCGGCATCCCGCTCGCGGCGCTGGGCGTGTCGGCGGTGGCCACCGGGAT
CTGCGTGCTGATCAACTACCTGATGCCGGGCAAGGCGTTCGGCTTCCTGATGGGGCTGGTGGTCTCGGCGCTGATCATCA
ACTGGGGGATGATCAGCTACATCCACCTGCGCTTTCGCCAGGCCAAGCGCGCGGCCGGCCAGACCACGCTGTTCCGCAGC
CTCGGCTATCCGTTCACGAACTGGCTCTGCCTCGCGTTCCTGGCGGCGATCCTGGTGGTGATGTACCTGGACCCGGATCT
GCGTCTGTCGGTTTACCTGATTCCGGCCTGGCTGGCCGTGCTCGGAATCGGGTATCGTCTGCGGGGGCGGCGTGCGAACG
ACGCTGCATCCGGCGCTTCCGTGCAATAG

Upstream 100 bases:

>100_bases
GGGGCGGGGGTGGCCGCCAACCGGCGGCGTCGATGAGGCAGAGACAGGTGCGGCCGATCCCGCCAGCCACGCAAGCGGGG
CCGCATGCTACGGAGACGAC

Downstream 100 bases:

>100_bases
CTCAGTTTCCCCGCTTCCTCCGCTTGATCAGGACTCACCATGTTCGAACACATCGATGCCTTTCCGGGCGACCCGATTCT
TTCGCTGAACGAGAATTTCC

Product: amino acid permease-associated subunit

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MVEPTENDNGGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQTAGPAVLLGYALGGIIAFFIMRQLGEMVVDEPVAGSF
SYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFALINLLNVVSVKSYGETEFWFAIV
KVAAVVGMIGFGAWLLLSGGAGPQAGVANLWRNGGFFPNGVGGLVSSMAVIMFSFGGLELVGITAAEADDPTRSIPRATN
QVIYRILIFYIGALGVLLSLFPWQKVVTGGSPFVLIFRALGSDLVADVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGN
APRALLSVSRRGIPLAALGVSAVATGICVLINYLMPGKAFGFLMGLVVSALIINWGMISYIHLRFRQAKRAAGQTTLFRS
LGYPFTNWLCLAFLAAILVVMYLDPDLRLSVYLIPAWLAVLGIGYRLRGRRANDAASGASVQ

Sequences:

>Translated_462_residues
MVEPTENDNGGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQTAGPAVLLGYALGGIIAFFIMRQLGEMVVDEPVAGSF
SYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFALINLLNVVSVKSYGETEFWFAIV
KVAAVVGMIGFGAWLLLSGGAGPQAGVANLWRNGGFFPNGVGGLVSSMAVIMFSFGGLELVGITAAEADDPTRSIPRATN
QVIYRILIFYIGALGVLLSLFPWQKVVTGGSPFVLIFRALGSDLVADVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGN
APRALLSVSRRGIPLAALGVSAVATGICVLINYLMPGKAFGFLMGLVVSALIINWGMISYIHLRFRQAKRAAGQTTLFRS
LGYPFTNWLCLAFLAAILVVMYLDPDLRLSVYLIPAWLAVLGIGYRLRGRRANDAASGASVQ
>Mature_462_residues
MVEPTENDNGGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQTAGPAVLLGYALGGIIAFFIMRQLGEMVVDEPVAGSF
SYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFALINLLNVVSVKSYGETEFWFAIV
KVAAVVGMIGFGAWLLLSGGAGPQAGVANLWRNGGFFPNGVGGLVSSMAVIMFSFGGLELVGITAAEADDPTRSIPRATN
QVIYRILIFYIGALGVLLSLFPWQKVVTGGSPFVLIFRALGSDLVADVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGN
APRALLSVSRRGIPLAALGVSAVATGICVLINYLMPGKAFGFLMGLVVSALIINWGMISYIHLRFRQAKRAAGQTTLFRS
LGYPFTNWLCLAFLAAILVVMYLDPDLRLSVYLIPAWLAVLGIGYRLRGRRANDAASGASVQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=448, Percent_Identity=68.0803571428571, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=62.5835189309577, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=42.1052631578947, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI1790653, Length=453, Percent_Identity=39.2935982339956, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=45.0549450549451, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI87081915, Length=460, Percent_Identity=37.3913043478261, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789017, Length=421, Percent_Identity=38.2422802850356, Blast_Score=287, Evalue=8e-79,
Organism=Escherichia coli, GI87081708, Length=437, Percent_Identity=35.2402745995423, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1788480, Length=426, Percent_Identity=36.3849765258216, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87081869, Length=187, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082023, Length=190, Percent_Identity=26.8421052631579, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=409, Percent_Identity=35.9413202933985, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6320772, Length=408, Percent_Identity=35.7843137254902, Blast_Score=232, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=35.2144469525959, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=445, Percent_Identity=32.5842696629214, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=469, Percent_Identity=32.6226012793177, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=33.4939759036145, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321053, Length=436, Percent_Identity=32.1100917431193, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=416, Percent_Identity=30.5288461538462, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=414, Percent_Identity=31.6425120772947, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=31.6455696202532, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=29.8765432098765, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=421, Percent_Identity=31.1163895486936, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319608, Length=442, Percent_Identity=28.9592760180996, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319543, Length=434, Percent_Identity=30.184331797235, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=409, Percent_Identity=28.6063569682152, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=408, Percent_Identity=29.1666666666667, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=29.5739348370927, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=480, Percent_Identity=23.5416666666667, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24666159, Length=367, Percent_Identity=22.8882833787466, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221512776, Length=367, Percent_Identity=22.8882833787466, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667468, Length=284, Percent_Identity=25.3521126760563, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49497; Mature: 49497

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPTENDNGGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQTAGPAVLLGYALGGIIA
CCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FFIMRQLGEMVVDEPVAGSFSYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
YWWPGVPTWVSALVFFALINLLNVVSVKSYGETEFWFAIVKVAAVVGMIGFGAWLLLSGG
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECC
AGPQAGVANLWRNGGFFPNGVGGLVSSMAVIMFSFGGLELVGITAAEADDPTRSIPRATN
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHH
QVIYRILIFYIGALGVLLSLFPWQKVVTGGSPFVLIFRALGSDLVADVLNVVVLTAALSV
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
YNSGVYCNSRMLFGLAQQGNAPRALLSVSRRGIPLAALGVSAVATGICVLINYLMPGKAF
HCCCCEECCHHHEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
GFLMGLVVSALIINWGMISYIHLRFRQAKRAAGQTTLFRSLGYPFTNWLCLAFLAAILVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
MYLDPDLRLSVYLIPAWLAVLGIGYRLRGRRANDAASGASVQ
HHCCCCCCEEEEHHHHHHHHHCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVEPTENDNGGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQTAGPAVLLGYALGGIIA
CCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FFIMRQLGEMVVDEPVAGSFSYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
YWWPGVPTWVSALVFFALINLLNVVSVKSYGETEFWFAIVKVAAVVGMIGFGAWLLLSGG
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECC
AGPQAGVANLWRNGGFFPNGVGGLVSSMAVIMFSFGGLELVGITAAEADDPTRSIPRATN
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHH
QVIYRILIFYIGALGVLLSLFPWQKVVTGGSPFVLIFRALGSDLVADVLNVVVLTAALSV
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
YNSGVYCNSRMLFGLAQQGNAPRALLSVSRRGIPLAALGVSAVATGICVLINYLMPGKAF
HCCCCEECCHHHEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
GFLMGLVVSALIINWGMISYIHLRFRQAKRAAGQTTLFRSLGYPFTNWLCLAFLAAILVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
MYLDPDLRLSVYLIPAWLAVLGIGYRLRGRRANDAASGASVQ
HHCCCCCCEEEEHHHHHHHHHCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]