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The map label for this gene is tyrB [H]

Identifier: 238024637

GI number: 238024637

Start: 1604229

End: 1605431

Strand: Reverse

Name: tyrB [H]

Synonym: bglu_2g12520

Alternate gene names: 238024637

Gene position: 1605431-1604229 (Counterclockwise)

Preceding gene: 238024638

Following gene: 238024636

Centisome position: 56.78

GC content: 68.41

Gene sequence:

>1203_bases
ATGTTCGAACACATCGATGCCTTTCCGGGCGACCCGATTCTTTCGCTGAACGAGAATTTCCAACACGATCCGCGCGAGCG
GAAAGTCAACCTGAGCATCGGCATCTATTTCGACGAGGCCGGCAAGATTCCCGTGATGGGCGCCGTGCGCGAGGCCGAGC
GGCAACTCGCGGCCGCGGTCGGCCCGAAGCCGTACCTGCCGATGGCCGGCATCGCCGGCTATCGCGATGCGGTGCAGACG
CTCGTGTTCGGCAAGGACTGCGCGGCGCGCGATGCGGGCCGCATCGCCACGGTGCAGACGGTGGGGGGCTCGGGCGCGCT
GAAGGTCGGCGCCGATTTCATCAAGCGTTATTTTCCCGACACGCCGATCTGGGTCAGCGACCCGAGCTGGGAAAACCACC
GCTTCGTATTCGAGCGCGCGGGCCTGACGGTCGACACCTATCCGTATTACGACGATGCCACGGGCGGCCTTCGCTTCGAG
GCGATGCTCGCCGCGCTCGACGCGCTGCCGGCGCGCAGCGCGGTGCTGCTGCATGCCTGCTGCCACAACCCGACGGGCGT
GGACCTCGACGACGCGCAGTGGCTCAAGGTGATCGACGTGCTGCAGGCGCGCGAGCTGCTGCCGTTCATCGACATGGCCT
ACCAGGGCTTCGGCGCGGGCCTCGACGCCGACGCGTTCGCGGTGCGCGAGCTGGCGCGGCGCGGGATTCCGGCGCTCGTC
GCCACCTCGTTCTCGAAGAACTTCTCGATCTACGGCGAGCGCTGCGGCAGCCTGTCGGTGATCTGCGAGGACGCGGCCAC
CGCCCAGCGCGTGCTGGGCCAGCTGGCCAGCAACGTGCGCGCGATCTACAGCAATCCGCCCACGCAGGGCGCGAAGATCG
TCACGACCGTGCTGGACTCGCCGGAACTGCGCGCGCAGTGGGAGGAGGAACTGGCCTCGATGTGCCGGCGCATCGCCCGG
ATGCGCACCGCGATCCACGACGGCCTGCGCGAGCACGTGCCGGCCGAGGCGCTGTCGCGCTACGTCAAGCAGCGCGGCAT
GTTCACCTACAGCGGCCTGACCGGCACCCAGGTGGACGTGCTGCGCGAGAAGCACGGCGTCTACATCCTGCGCTCGGGCC
GCATGTGCGTGGCCGGGCTCAACGAGTCGAACGTCGCGATCGTGGCCGAGGCGATCGGCGAGGTGATCGCAAGCGGCGTG
TAA

Upstream 100 bases:

>100_bases
CGGGTATCGTCTGCGGGGGCGGCGTGCGAACGACGCTGCATCCGGCGCTTCCGTGCAATAGCTCAGTTTCCCCGCTTCCT
CCGCTTGATCAGGACTCACC

Downstream 100 bases:

>100_bases
GCGAGCGGGGCGCGACGGCCTCTTTTCACGGGGCTGCTCGTGCTTGCTTTCACGCCGTTTTCCATGCCGGCGCCGCCGCG
CGCCCGGCAGTCCGTCTGGA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFEHIDAFPGDPILSLNENFQHDPRERKVNLSIGIYFDEAGKIPVMGAVREAERQLAAAVGPKPYLPMAGIAGYRDAVQT
LVFGKDCAARDAGRIATVQTVGGSGALKVGADFIKRYFPDTPIWVSDPSWENHRFVFERAGLTVDTYPYYDDATGGLRFE
AMLAALDALPARSAVLLHACCHNPTGVDLDDAQWLKVIDVLQARELLPFIDMAYQGFGAGLDADAFAVRELARRGIPALV
ATSFSKNFSIYGERCGSLSVICEDAATAQRVLGQLASNVRAIYSNPPTQGAKIVTTVLDSPELRAQWEEELASMCRRIAR
MRTAIHDGLREHVPAEALSRYVKQRGMFTYSGLTGTQVDVLREKHGVYILRSGRMCVAGLNESNVAIVAEAIGEVIASGV

Sequences:

>Translated_400_residues
MFEHIDAFPGDPILSLNENFQHDPRERKVNLSIGIYFDEAGKIPVMGAVREAERQLAAAVGPKPYLPMAGIAGYRDAVQT
LVFGKDCAARDAGRIATVQTVGGSGALKVGADFIKRYFPDTPIWVSDPSWENHRFVFERAGLTVDTYPYYDDATGGLRFE
AMLAALDALPARSAVLLHACCHNPTGVDLDDAQWLKVIDVLQARELLPFIDMAYQGFGAGLDADAFAVRELARRGIPALV
ATSFSKNFSIYGERCGSLSVICEDAATAQRVLGQLASNVRAIYSNPPTQGAKIVTTVLDSPELRAQWEEELASMCRRIAR
MRTAIHDGLREHVPAEALSRYVKQRGMFTYSGLTGTQVDVLREKHGVYILRSGRMCVAGLNESNVAIVAEAIGEVIASGV
>Mature_400_residues
MFEHIDAFPGDPILSLNENFQHDPRERKVNLSIGIYFDEAGKIPVMGAVREAERQLAAAVGPKPYLPMAGIAGYRDAVQT
LVFGKDCAARDAGRIATVQTVGGSGALKVGADFIKRYFPDTPIWVSDPSWENHRFVFERAGLTVDTYPYYDDATGGLRFE
AMLAALDALPARSAVLLHACCHNPTGVDLDDAQWLKVIDVLQARELLPFIDMAYQGFGAGLDADAFAVRELARRGIPALV
ATSFSKNFSIYGERCGSLSVICEDAATAQRVLGQLASNVRAIYSNPPTQGAKIVTTVLDSPELRAQWEEELASMCRRIAR
MRTAIHDGLREHVPAEALSRYVKQRGMFTYSGLTGTQVDVLREKHGVYILRSGRMCVAGLNESNVAIVAEAIGEVIASGV

Specific function: catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) or glutamate as the amino donors. Histidine, leucine, asparagine, or arginine are also functional

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=40.4040404040404, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI4504067, Length=393, Percent_Identity=38.4223918575064, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI117414139, Length=388, Percent_Identity=26.2886597938144, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=56.1712846347607, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=44.4444444444444, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=395, Percent_Identity=40.253164556962, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI25147133, Length=395, Percent_Identity=39.4936708860759, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17569539, Length=399, Percent_Identity=37.844611528822, Blast_Score=284, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17569537, Length=385, Percent_Identity=32.2077922077922, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17550384, Length=268, Percent_Identity=36.5671641791045, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147136, Length=211, Percent_Identity=38.3886255924171, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=37.5308641975309, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6322743, Length=427, Percent_Identity=32.7868852459016, Blast_Score=235, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=40.3100775193798, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=40.3100775193798, Blast_Score=300, Evalue=8e-82,
Organism=Drosophila melanogaster, GI24580972, Length=396, Percent_Identity=39.3939393939394, Blast_Score=300, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=39.3939393939394, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=39.8457583547558, Blast_Score=298, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5; =2.6.1.57; =2.6.1.1 [H]

Molecular weight: Translated: 43538; Mature: 43538

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHIDAFPGDPILSLNENFQHDPRERKVNLSIGIYFDEAGKIPVMGAVREAERQLAAAV
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHC
GPKPYLPMAGIAGYRDAVQTLVFGKDCAARDAGRIATVQTVGGSGALKVGADFIKRYFPD
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCC
TPIWVSDPSWENHRFVFERAGLTVDTYPYYDDATGGLRFEAMLAALDALPARSAVLLHAC
CCEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
CHNPTGVDLDDAQWLKVIDVLQARELLPFIDMAYQGFGAGLDADAFAVRELARRGIPALV
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEE
ATSFSKNFSIYGERCGSLSVICEDAATAQRVLGQLASNVRAIYSNPPTQGAKIVTTVLDS
HHHCCCCCEEHHCCCCCEEEEECHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCC
PELRAQWEEELASMCRRIARMRTAIHDGLREHVPAEALSRYVKQRGMFTYSGLTGTQVDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCHHHH
LREKHGVYILRSGRMCVAGLNESNVAIVAEAIGEVIASGV
HHHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEHIDAFPGDPILSLNENFQHDPRERKVNLSIGIYFDEAGKIPVMGAVREAERQLAAAV
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHC
GPKPYLPMAGIAGYRDAVQTLVFGKDCAARDAGRIATVQTVGGSGALKVGADFIKRYFPD
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCC
TPIWVSDPSWENHRFVFERAGLTVDTYPYYDDATGGLRFEAMLAALDALPARSAVLLHAC
CCEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
CHNPTGVDLDDAQWLKVIDVLQARELLPFIDMAYQGFGAGLDADAFAVRELARRGIPALV
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEE
ATSFSKNFSIYGERCGSLSVICEDAATAQRVLGQLASNVRAIYSNPPTQGAKIVTTVLDS
HHHCCCCCEEHHCCCCCEEEEECHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCC
PELRAQWEEELASMCRRIARMRTAIHDGLREHVPAEALSRYVKQRGMFTYSGLTGTQVDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCHHHH
LREKHGVYILRSGRMCVAGLNESNVAIVAEAIGEVIASGV
HHHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074065 [H]