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The map label for this gene is uvrY [H]

Identifier: 238024634

GI number: 238024634

Start: 1602451

End: 1603095

Strand: Direct

Name: uvrY [H]

Synonym: bglu_2g12490

Alternate gene names: 238024634

Gene position: 1602451-1603095 (Clockwise)

Preceding gene: 238024633

Following gene: 238024639

Centisome position: 56.68

GC content: 67.13

Gene sequence:

>645_bases
ATGATCCATGTGCTGATTGCCGACGATCACGCGCTCGTGCGCGACGGGCTGCGCCACATCCTGCGGGACGCCACCGGCTT
CGAAGTCGCCGGCGAAGCCTACGACAGCGCCTCCACGATCGCCCTGATCCGCGCCACGCCGGCCCAGGTGCTGGTGCTCG
ATCTATCGATGCCGGGCCGCAACGGCGTCGAGCTGATCCGCCAGATCAAGGACGAGAAACCGACGCTGCGAATCCTCGTG
CTGACCATGCATGCCGAACAGCAATATGCGCTACGCGCGTTTCGCGCCGGCGCGTCCGGCTACCTGACCAAGGAAAGCGC
GAGCGCCGAACTGGTGGGCGCGGTCGCGAAGGTGGCCTCGGGCGGCGTCTACGTGAGCCTGTCGATGGCCGAGCGCTTCG
CCCAGAGCCTCAACGAGCCGGCCGACACGCTGCCGCACCAGCGGCTGTCGGACCGCGAATTCGACGTGTTTCGGCGCATC
GCGGCGGGCCAGACGCTGACCGAGATCGCCAACGCGCTGTGCGTGAGCGCGAAGACGGTCAGCACCTACAAGACGCGGAT
CCTGGAAAAGATGCAGATGCCGCACGAAGCGGCGCTGGTGCGCTACGCGCTGCGGCACCGGCTGATCGACGATCCGGACG
ATTGA

Upstream 100 bases:

>100_bases
ACATGCTGGGCGGCACCGTGCGCATGGAGACGGCGCGCAACCAGGGCTACGCGCTCACGATCACGATCCCCCTGCCTTCG
ACACCGGACCCGAACCTGCC

Downstream 100 bases:

>100_bases
CGCGTCGTTTCGTGCAGCCGGGGCCGGCAGCACGAAACGGCGAGCGGGCGGAAACGGCGCGGGGCCGCCGGCGCGGCCGG
CGCGGCGAAGGCGGCGAAGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIHVLIADDHALVRDGLRHILRDATGFEVAGEAYDSASTIALIRATPAQVLVLDLSMPGRNGVELIRQIKDEKPTLRILV
LTMHAEQQYALRAFRAGASGYLTKESASAELVGAVAKVASGGVYVSLSMAERFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIANALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHRLIDDPDD

Sequences:

>Translated_214_residues
MIHVLIADDHALVRDGLRHILRDATGFEVAGEAYDSASTIALIRATPAQVLVLDLSMPGRNGVELIRQIKDEKPTLRILV
LTMHAEQQYALRAFRAGASGYLTKESASAELVGAVAKVASGGVYVSLSMAERFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIANALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHRLIDDPDD
>Mature_214_residues
MIHVLIADDHALVRDGLRHILRDATGFEVAGEAYDSASTIALIRATPAQVLVLDLSMPGRNGVELIRQIKDEKPTLRILV
LTMHAEQQYALRAFRAGASGYLTKESASAELVGAVAKVASGGVYVSLSMAERFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIANALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHRLIDDPDD

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=37.914691943128, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=29.1866028708134, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=33.8235294117647, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=32.8571428571429, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=29.1208791208791, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082052, Length=118, Percent_Identity=32.2033898305085, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23507; Mature: 23507

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVLIADDHALVRDGLRHILRDATGFEVAGEAYDSASTIALIRATPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEECCCEEEEEEECCCCC
NGVELIRQIKDEKPTLRILVLTMHAEQQYALRAFRAGASGYLTKESASAELVGAVAKVAS
HHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGVYVSLSMAERFAQSLNEPADTLPHQRLSDREFDVFRRIAAGQTLTEIANALCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILEKMQMPHEAALVRYALRHRLIDDPDD
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIHVLIADDHALVRDGLRHILRDATGFEVAGEAYDSASTIALIRATPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEECCCEEEEEEECCCCC
NGVELIRQIKDEKPTLRILVLTMHAEQQYALRAFRAGASGYLTKESASAELVGAVAKVAS
HHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGVYVSLSMAERFAQSLNEPADTLPHQRLSDREFDVFRRIAAGQTLTEIANALCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILEKMQMPHEAALVRYALRHRLIDDPDD
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]