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The map label for this gene is uvrC [H]

Identifier: 237813184

GI number: 237813184

Start: 2872747

End: 2874990

Strand: Reverse

Name: uvrC [H]

Synonym: GBP346_A2949

Alternate gene names: 237813184

Gene position: 2874990-2872747 (Counterclockwise)

Preceding gene: 237813185

Following gene: 237813183

Centisome position: 70.15

GC content: 69.92

Gene sequence:

>2244_bases
ATGACATCCCCCGACGCACCCGAATCCCGTTTCGAACCCAAGCCGATCCTCGCCCAACTGCCGCATCTGCCTGGCGTCTA
CCGTTACTACGACGCGCAGGACGCGGTGCTGTACGTCGGCAAGGCGCGCGACCTGAAAAAGCGCGTGTCGAGCTACTTCA
CGAAAACGCAGCTGTCGCCGCGCATCGCGATGATGATCACGCGCATCGCGCGCATCGAGACCACGGTCACGCGCTCGGAG
GCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCGCTCGCGCCGCGCTACAACATCCTGTTTCGCGACGACAAGTC
GTATCCGTACCTGAAGCTCACGGGCCATCGGTTTCCGCGAATGGCGTATTACCGCGGCGCGGTCGACAAGAAGAACCAGT
ACTTCGGGCCGTTTCCGAGCGCGTGGGCGGTGCGCGAGAGCATCCAGATCCTGCAGCGCGTGTTCCAGTTGCGCACCTGC
GAGGACTCGGTGTTCAACAACCGCACGCGCCCGTGCCTGCTGCACCAGATCGGCCGCTGCTCGGCGCCGTGCGTCGGCGC
GATCGGCGAGGAGGACTACGCGCGCGACGTCGACAACGCGTCGCGCTTCCTGCTCGGCCGGCAGGGCGAGGTGATGGGCG
AGCTCGAGCGAAAGATGCACGCGTTTGCCGCCGAGCTGAAGTTCGAGCAGGCCGCGGCCGTGCGCAACCAGATGAGCTCG
CTCGCGAAGGTGCTGCATCAGCAGGCGATCGACGTTGGCGGCGACAGCGACGTCGACATCCTCGCGGTCGTCGCGCAGGG
CGGCCGTGTGTGCGTGAACCTTGCGATGGTGCGCGGCGGCCGGCATCTCGGCGACAAGGCGTATTTCCCGGCGCACGTCG
AAACCGCGCTCGCGCTCGCGGGCGATATCGAAGCGCTGGCCGGCGAAGGCGCCGGCGACGGCGTGCAGGCTGCGGCGCAG
CCCGCGCAAGCGCCGCTCGCGACGGACGCGGATGCGACGGATGCGGCGGCGACTGAGGCGAAGACCGTGACGGCGGCCGC
GGCGGCGCGTGCGGGCGCTCGTACGGCGCAGGCCGCCGGAGCGCGCGCCGCCGCGAGCGCCGAAGGCGATGTCGAGCGAC
GTGCGGAGGGAGAAACGCACGCGCGCGCCGACGCGCGCGAAGCCGCCGCACTGCCCGACGGCGCCGCCGCTGCTCAGGAA
GCGGACGCGGACGTCGACGCCGCGCCGCTCGAAACCGAGGTGCTCGAAGCGTTCATCGCACAGCACTATCTCGGCAATCG
CGTGCCGCCGGTTCTCGTCGTGAGCCATGCGCCCGCGAATCGCGAGCTGATCGATCTGCTCGTCGAACAGGCGGGGCACA
AGGTCGCGGTCGTGCGGCAGCCGCAGGGCCAGAAGCGCGCGTGGCTCACGATGGCCGAGCAGAACGCGCGCCTCGCGCTC
GCGCGGCTGTTGTCCGAGCAGGGCTCGCAGCAGGCGCGCACGCGCTCGCTCGCCGACGTGCTCGGCTACGAGAGCGACGA
TCTCGCGCAGCTGCGCATCGAGTGCTTCGACATCAGCCACACGATGGGCGAGGCGACGCAAGCGTCGTGCGTCGTCTATC
ACCATCACAGGATGCAGTCGTCCGAGTACCGCCGCTACAACATCGCGGGAATCACGCCCGGCGACGACTACGCGGCGATG
CGCCAGGTGCTCACGCGCCGCTACGAGAAGATGGTCGAGGAGGCGGCTGCCGAGGCGTCGGCCGACGAGGCGGCCGGCAT
CGACGGCAATGCGGTGCATGCGGCCGCTTCGGCGGGGCGGCTGCCGAACGTCGTGCTGATCGACGGCGGCCGGGGCCAGG
TCGAGATCGCGCGCCAGGTGTTTTCCGAGCTCGGGCTCGATATCTCGATGCTCGTCGGCGTCGCGAAGGGCGAGGGACGC
AAGGTCGGGCTCGAGACGCTGATCTTCGCCGACGGCCGCGCGCCGCTCGAGCTCGGCAAGGAGAGCGCGGCGCTGATGCT
CGTCGCGCAGATCCGCGACGAGGCGCACCGTTTCGCGATCACCGGGATGCGCGCGAAGCGGGCGAAGACGCGGCAGACGT
CGCGGCTCGAGGAACTGGAGGGCGTCGGTGCGAAGCGCCGGCAGCGGCTGCTCGCGCGCTTCGGCGGCCTGCGCGGCGTC
GTCGCCGCGAGCGTCGACGAGCTCGCGAGCGTCGAAGGCATTTCCCGCGCGCTCGCCGAGCAGATCTACCGGCAACTCCA
CTGA

Upstream 100 bases:

>100_bases
CGCGCGGCGGCGGCCGGGCCGCGTTCGCGCGCGGCGAATGCTCTACACTGGCGATTCTAAATGACCTTGTTCGCGCGCGC
CGCTCGCGCCCGCATTGAGC

Downstream 100 bases:

>100_bases
GCGCGGGCGCGCCGCCGGGCGGCCTTGCGCGGCTCGCGCCGGGCGGCGCGGCCCGTGCCGGGCGCCTTGCTTGTGGCGGC
GCGGGCGACGCGGCACAATG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSS
LAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAAAQ
PAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQE
ADADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLAL
ARLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAM
RQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGR
KVGLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGV
VAASVDELASVEGISRALAEQIYRQLH

Sequences:

>Translated_747_residues
MTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSS
LAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAAAQ
PAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQE
ADADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLAL
ARLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAM
RQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGR
KVGLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGV
VAASVDELASVEGISRALAEQIYRQLH
>Mature_746_residues
TSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTRSEA
EALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCE
DSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSSL
AKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAAAQP
AQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEA
DADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALA
RLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAMR
QVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRK
VGLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVV
AASVDELASVEGISRALAEQIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=326, Percent_Identity=43.2515337423313, Blast_Score=289, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 80809; Mature: 80677

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMITRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCC
MAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
SAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALA
HHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
GDIEALAGEGAGDGVQAAAQPAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAG
CCHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
ARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADADVDAAPLETEVLEAFIA
CHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
QHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLAL
HHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHCCHHHHH
ARLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQS
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHCCCCCCCEEEEEHHHCCC
SEYRRYNIAGITPGDDYAAMRQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGR
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCC
LPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVGLETLIFADGRAPLELGK
CCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECCEEEEEECCCCHHHHCC
ESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
VAASVDELASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMITRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCC
MAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
SAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALA
HHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
GDIEALAGEGAGDGVQAAAQPAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAG
CCHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
ARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADADVDAAPLETEVLEAFIA
CHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
QHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLAL
HHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHCCHHHHH
ARLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQS
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHCCCCCCCEEEEEHHHCCC
SEYRRYNIAGITPGDDYAAMRQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGR
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCC
LPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVGLETLIFADGRAPLELGK
CCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECCEEEEEECCCCHHHHCC
ESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
VAASVDELASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA