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The map label for this gene is pgsA [H]

Identifier: 237813183

GI number: 237813183

Start: 2872026

End: 2872649

Strand: Reverse

Name: pgsA [H]

Synonym: GBP346_A2948

Alternate gene names: 237813183

Gene position: 2872649-2872026 (Counterclockwise)

Preceding gene: 237813184

Following gene: 237813180

Centisome position: 70.09

GC content: 63.46

Gene sequence:

>624_bases
ATGGCAAATCCTTCAACCGTGTCGCGTGCCATGCCGTTCAATTTCCCGATTTTCCTGACGTGGGTGCGAATCGTGCTGAT
TCCGCTCGTCGTCGGTGTGTTTTATCTGCCGGACACGATGCTGAGCGCCGACCATCGCAATCTGGCGGCGGCCGTGATTT
TCATTCTCGCCGCGCTGACCGACTGGTTCGACGGTTATCTCGCGCGGAAGTGGAACCAGACGTCGGCGTTCGGCGCGTTT
CTCGACCCGGTCGCCGACAAGCTGATGGTGACGGCCGCGCTGCTGATGCTCGTGCAGCTCGCGCGCATCGACGCGGCGAT
CGCGCTCGTGATCGTCGGCCGCGAAATCGCGATCTCGGCGCTGCGCGAATGGATGGCGCAGATCGGCGCATCGAAGAGCG
TCGCGGTGAATTCGCTGGGCAAGTTCAAGACCGCGTGCCAGATGGTCGCGATTCCGATGCTGCTCTTCTACGGCCGGCTG
CCGTTCGGCGGCGGCGTCGCGATCGACACGCGCGGATGGGGCGAATGGCTGATCTATCTCGCGGCCGTGTTGACCATCTG
GTCGATGCTTTACTACATGAAGCTCGCGTGGCCGCAGATTCGCGAGCGCGGCGGCGCGGCCTGA

Upstream 100 bases:

>100_bases
TGAGCGCGGGCGCGCCGCCGGGCGGCCTTGCGCGGCTCGCGCCGGGCGGCGCGGCCCGTGCCGGGCGCCTTGCTTGTGGC
GGCGCGGGCGACGCGGCACA

Downstream 100 bases:

>100_bases
GCGCGCCGCGGACCCGCACGGCGAGGCGCGAGGCGAACACACGCTGAACTGCAGGCCGGATGGCGCGTCGGCAAGGGCAT
CGAGGTCGTCGAAGAAAAAG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MANPSTVSRAMPFNFPIFLTWVRIVLIPLVVGVFYLPDTMLSADHRNLAAAVIFILAALTDWFDGYLARKWNQTSAFGAF
LDPVADKLMVTAALLMLVQLARIDAAIALVIVGREIAISALREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFYGRL
PFGGGVAIDTRGWGEWLIYLAAVLTIWSMLYYMKLAWPQIRERGGAA

Sequences:

>Translated_207_residues
MANPSTVSRAMPFNFPIFLTWVRIVLIPLVVGVFYLPDTMLSADHRNLAAAVIFILAALTDWFDGYLARKWNQTSAFGAF
LDPVADKLMVTAALLMLVQLARIDAAIALVIVGREIAISALREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFYGRL
PFGGGVAIDTRGWGEWLIYLAAVLTIWSMLYYMKLAWPQIRERGGAA
>Mature_206_residues
ANPSTVSRAMPFNFPIFLTWVRIVLIPLVVGVFYLPDTMLSADHRNLAAAVIFILAALTDWFDGYLARKWNQTSAFGAFL
DPVADKLMVTAALLMLVQLARIDAAIALVIVGREIAISALREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFYGRLP
FGGGVAIDTRGWGEWLIYLAAVLTIWSMLYYMKLAWPQIRERGGAA

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=192, Percent_Identity=47.9166666666667, Blast_Score=152, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22801; Mature: 22670

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPSTVSRAMPFNFPIFLTWVRIVLIPLVVGVFYLPDTMLSADHRNLAAAVIFILAALT
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHH
DWFDGYLARKWNQTSAFGAFLDPVADKLMVTAALLMLVQLARIDAAIALVIVGREIAISA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFYGRLPFGGGVAIDTRGWGEWLIYL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHH
AAVLTIWSMLYYMKLAWPQIRERGGAA
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANPSTVSRAMPFNFPIFLTWVRIVLIPLVVGVFYLPDTMLSADHRNLAAAVIFILAALT
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHH
DWFDGYLARKWNQTSAFGAFLDPVADKLMVTAALLMLVQLARIDAAIALVIVGREIAISA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFYGRLPFGGGVAIDTRGWGEWLIYL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHH
AAVLTIWSMLYYMKLAWPQIRERGGAA
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]