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The map label for this gene is ppi [H]

Identifier: 23501972

GI number: 23501972

Start: 1068534

End: 1069124

Strand: Reverse

Name: ppi [H]

Synonym: BR1094

Alternate gene names: 23501972

Gene position: 1069124-1068534 (Counterclockwise)

Preceding gene: 23501973

Following gene: 23501971

Centisome position: 50.72

GC content: 56.18

Gene sequence:

>591_bases
ATGTCTTTCATTCGCTCGGCGCTGGCCGCTGCCGCTTTTGTCGCGCTCTCGATCGGTGCAGTGCAGACCGCATCGGCTGC
CGATCCTGAAAATACCGTTATTTTGAAACTGAAGGACGGCGATGTCGCACTTGAGCTTCGCCCCGATCTTGCGCCGAAGC
ATGTGGCGCAGATCAAGAAACTGGTGCGCGAAGGCGCTTATAACGGCGTGGCTTTCCACCGCGTTATTCCGGGTTTCATG
GCGCAGACAGGCGACGTAAAATTCGGCAATATGGACAAGGGCTTCGACGCGGCCCGCGTTGGTACCGGCGGCTCGAACTA
CCCCGATCTCCCGGCGGAATTTTCCAAGGAACCTTTCGTGCGCGGCACGGTTGGCATGGCGCGCAGCCAGAATCCGAATT
CGGCCAATTCACAGTTTTTCATCATGTTTGATGACGGCCCGTTCCTCAATGGACAATATACGGTCGTGGGCAAGGTTGTC
AGCGGCATGGATGCCGTGGACAAGATTAAGAAGGGCAGCGAAGCCGAGAATGGTGCCGTGAAGAATCCCGACAAAATCAT
CAAGGCCACCATCGAAGCTGACACGAAGTAA

Upstream 100 bases:

>100_bases
TTGCGTCCATGGGCGGGGACATCAAGCCCTTCGTTCCGGTGGCCGTCGCTGCCGCCTTGAACACCAAATTCAAATCCTGA
CCGCAGGGAGTTTTTCGATC

Downstream 100 bases:

>100_bases
CACCCATCTGGCGCCCCGGAAACGGTTGAACTTTCGGGGTGCAAATCAACAGGAGAGGCCCAATGGCTTATAAAGACCCA
GAAAATACGCTCGTTCTCGA

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKKLVREGAYNGVAFHRVIPGFM
AQTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFVRGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVV
SGMDAVDKIKKGSEAENGAVKNPDKIIKATIEADTK

Sequences:

>Translated_196_residues
MSFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKKLVREGAYNGVAFHRVIPGFM
AQTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFVRGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVV
SGMDAVDKIKKGSEAENGAVKNPDKIIKATIEADTK
>Mature_195_residues
SFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKKLVREGAYNGVAFHRVIPGFMA
QTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFVRGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVVS
GMDAVDKIKKGSEAENGAVKNPDKIIKATIEADTK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI5031987, Length=139, Percent_Identity=38.1294964028777, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI24308049, Length=161, Percent_Identity=32.2981366459627, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI45439316, Length=144, Percent_Identity=32.6388888888889, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7706339, Length=148, Percent_Identity=31.0810810810811, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=34.2857142857143, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI22547212, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI7657473, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI22547215, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=186, Percent_Identity=38.7096774193548, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786736, Length=156, Percent_Identity=37.1794871794872, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=35.6164383561644, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=35.6164383561644, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=144, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=140, Percent_Identity=35, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=32.3170731707317, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=146, Percent_Identity=31.5068493150685, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552782, Length=153, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=30.379746835443, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=141, Percent_Identity=34.7517730496454, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=36.6906474820144, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322492, Length=158, Percent_Identity=32.9113924050633, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=33.1325301204819, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664125, Length=141, Percent_Identity=36.1702127659575, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357783, Length=141, Percent_Identity=36.1702127659575, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922376, Length=156, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45549139, Length=159, Percent_Identity=35.2201257861635, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24652460, Length=140, Percent_Identity=35, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136360, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922912, Length=139, Percent_Identity=35.9712230215827, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20751; Mature: 20620

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKK
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHH
LVREGAYNGVAFHRVIPGFMAQTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFV
HHHHCCCCCEEHHHHHHHHHHCCCCEEECCCCCCCCCEEECCCCCCCCCCCHHCCCCCCC
RGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVVSGMDAVDKIKKGSEAENGAV
EECCCCCCCCCCCCCCCEEEEEECCCCEECCCEEEEHHHHHCHHHHHHHHCCCCCCCCCC
KNPDKIIKATIEADTK
CCHHHHEEEEEECCCC
>Mature Secondary Structure 
SFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHH
LVREGAYNGVAFHRVIPGFMAQTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFV
HHHHCCCCCEEHHHHHHHHHHCCCCEEECCCCCCCCCEEECCCCCCCCCCCHHCCCCCCC
RGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVVSGMDAVDKIKKGSEAENGAV
EECCCCCCCCCCCCCCCEEEEEECCCCEECCCEEEEHHHHHCHHHHHHHHCCCCCCCCCC
KNPDKIIKATIEADTK
CCHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA