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The map label for this gene is hprK2

Identifier: 23100883

GI number: 23100883

Start: 3566670

End: 3567590

Strand: Reverse

Name: hprK2

Synonym: OB3428

Alternate gene names: 23100883

Gene position: 3567590-3566670 (Counterclockwise)

Preceding gene: 23100884

Following gene: 23100881

Centisome position: 98.27

GC content: 40.72

Gene sequence:

>921_bases
GTGAAATCCATTCAAGTACAACAACTAGTAGAAGAATTTAATTTAGAGGTGTTAGCGGGAGAGGATCATCGAGAGCGGAC
AATTACAAAATCTCGCACACATCGACCGGGGCTAGAGTTTATCGGTTATTTCGATTTCTTTCCAATGGAGCGGGTGCAGA
TATTAGGCAAAAAGGAAATTAACTACCTCCATCAGCTAAATGAACAAGAACGAGATATCCGGATTGGGAATGTAGTAAAT
TATCATCCACCTTGCTTTATCGTAACCTCGGATCAAGATGGGCTTACTTATTTGAAGAAATATTGTCATGCAGAACAAAT
ACCGCTGTTACGAACGAAAGAAGCAACGGTTGATTTTATGGCAAAAGTCGATCACTACCTTACTAGAAAACTTGCACCAG
AAATTGCCGTTCACGGGGTTTGTATGAATGTGTTAGGGATCGGTATTCTGATTCGTGGAGAATCTGGTGTTGGAAAAAGT
GAACTTGCTCATACATTACTTGGACGTGGGCATCGTTTAGTAGCAGATGATATCGTTGTACTAAAACGGTTAAGCCATAA
AACGATTCTAGGGACGCATAATGATAAAAACAAGGAGTTTCTAGCGTTACGAAGTGTTGGTTTATTAAATGTAGTCCGAG
CGTATGGTAGTAGAGCATTCCAAGATGAAACACGTATATCGCTTGATATAAAGCTGTCAAAGTGGGAAAAGGATTCGCTA
CATAATGAGTTGGAGTTCGAAACACAGTACCGAGATTACATGGGTGTATCTGTGCCAAGCATTGAAATTCAGCTGCAACC
AGGTCGTGACGTAGCTGGATTGATTGAAGCAGCAGCAAATAATTGGTACCTACAACAGCAAGGATATAGCGCAGCAGAAG
ACTTTATGAATCGAATTGAATGGCAGGATGGGGATGATTAA

Upstream 100 bases:

>100_bases
TCACTAGAGTGAACCAGTTTACAGCTCCTTTCCTGTATCTTTCCCCTTCAATTCGTTATAATGAAAGGAGAGCATTAGGA
ACGTAGAGGAGTGCAACGGA

Downstream 100 bases:

>100_bases
CCCCATCCTTTTTTATATTGGAACTGCTCTCTAAACCAAAAAATAGAAGAAAAGAGCGATAATTGGTTAATAGAGCGCTT
CTCTAAACCATGAATCAGGA

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P 2; HPr(Ser) kinase/phosphorylase 2

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKSIQVQQLVEEFNLEVLAGEDHRERTITKSRTHRPGLEFIGYFDFFPMERVQILGKKEINYLHQLNEQERDIRIGNVVN
YHPPCFIVTSDQDGLTYLKKYCHAEQIPLLRTKEATVDFMAKVDHYLTRKLAPEIAVHGVCMNVLGIGILIRGESGVGKS
ELAHTLLGRGHRLVADDIVVLKRLSHKTILGTHNDKNKEFLALRSVGLLNVVRAYGSRAFQDETRISLDIKLSKWEKDSL
HNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQGYSAAEDFMNRIEWQDGDD

Sequences:

>Translated_306_residues
MKSIQVQQLVEEFNLEVLAGEDHRERTITKSRTHRPGLEFIGYFDFFPMERVQILGKKEINYLHQLNEQERDIRIGNVVN
YHPPCFIVTSDQDGLTYLKKYCHAEQIPLLRTKEATVDFMAKVDHYLTRKLAPEIAVHGVCMNVLGIGILIRGESGVGKS
ELAHTLLGRGHRLVADDIVVLKRLSHKTILGTHNDKNKEFLALRSVGLLNVVRAYGSRAFQDETRISLDIKLSKWEKDSL
HNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQGYSAAEDFMNRIEWQDGDD
>Mature_306_residues
MKSIQVQQLVEEFNLEVLAGEDHRERTITKSRTHRPGLEFIGYFDFFPMERVQILGKKEINYLHQLNEQERDIRIGNVVN
YHPPCFIVTSDQDGLTYLKKYCHAEQIPLLRTKEATVDFMAKVDHYLTRKLAPEIAVHGVCMNVLGIGILIRGESGVGKS
ELAHTLLGRGHRLVADDIVVLKRLSHKTILGTHNDKNKEFLALRSVGLLNVVRAYGSRAFQDETRISLDIKLSKWEKDSL
HNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQGYSAAEDFMNRIEWQDGDD

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK2_OCEIH (Q8EL04)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_694350.1
- ProteinModelPortal:   Q8EL04
- SMR:   Q8EL04
- GeneID:   1016133
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB3428
- NMPDR:   fig|221109.1.peg.3432
- HOGENOM:   HBG566466
- OMA:   HESEMNG
- ProtClustDB:   PRK05428
- BioCyc:   OIHE221109:OB3428-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_01249
- InterPro:   IPR002078
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 35049; Mature: 35049

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00675 SIGMA54_INTERACT_1

Important sites: ACT_SITE 138-138 ACT_SITE 159-159 ACT_SITE 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIQVQQLVEEFNLEVLAGEDHRERTITKSRTHRPGLEFIGYFDFFPMERVQILGKKEI
CCCCHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCHHHEEHHCCCHHHHHHHHHHHHH
NYLHQLNEQERDIRIGNVVNYHPPCFIVTSDQDGLTYLKKYCHAEQIPLLRTKEATVDFM
HHHHHCCCHHCCEEECCEEEECCCEEEEECCCCCHHHHHHHHCHHCCCCEECCHHHHHHH
AKVDHYLTRKLAPEIAVHGVCMNVLGIGILIRGESGVGKSELAHTLLGRGHRLVADDIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCEEHHHHHHH
LKRLSHKTILGTHNDKNKEFLALRSVGLLNVVRAYGSRAFQDETRISLDIKLSKWEKDSL
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHH
HNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQGYSAAEDFMNRIE
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHCC
WQDGDD
CCCCCC
>Mature Secondary Structure
MKSIQVQQLVEEFNLEVLAGEDHRERTITKSRTHRPGLEFIGYFDFFPMERVQILGKKEI
CCCCHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCHHHEEHHCCCHHHHHHHHHHHHH
NYLHQLNEQERDIRIGNVVNYHPPCFIVTSDQDGLTYLKKYCHAEQIPLLRTKEATVDFM
HHHHHCCCHHCCEEECCEEEECCCEEEEECCCCCHHHHHHHHCHHCCCCEECCHHHHHHH
AKVDHYLTRKLAPEIAVHGVCMNVLGIGILIRGESGVGKSELAHTLLGRGHRLVADDIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCEEHHHHHHH
LKRLSHKTILGTHNDKNKEFLALRSVGLLNVVRAYGSRAFQDETRISLDIKLSKWEKDSL
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHH
HNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQGYSAAEDFMNRIE
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHCC
WQDGDD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376