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The map label for this gene is hprK1

Identifier: 23099937

GI number: 23099937

Start: 2538403

End: 2539335

Strand: Reverse

Name: hprK1

Synonym: OB2482

Alternate gene names: 23099937

Gene position: 2539335-2538403 (Counterclockwise)

Preceding gene: 23099938

Following gene: 23099936

Centisome position: 69.94

GC content: 37.3

Gene sequence:

>933_bases
ATGGTAGCGGTTGTCCGTACACAAGATTTATTGGATAATTTTAACCTGACTTTAGTATCTGGAGAAGACGGTATCCAACG
TGAAATAATAACAAGTGATATTTCTAGACCAGGAATAGAGATGACTGGCTATTTTAGATATTACCCTAAGGAACGTTTGC
AACTTATAGGTAAAACAGAAATGGCTTATTTTCTAGACTTAAGTTCGGAGCAAAGAAGAGATCGTGCTGAGCGCTTATGT
ACTGATATCACGCCAGGAATAGTTGTTTCAAGAGGGATGGACATACCTGAGGAGTTGAAGGAAGCCTCTGAAAAATCTGG
AGTTCCTATTCTTCAATCTCCTAGAAAAACGACTCGCGTTATTAGCCGATTAACCAATTATTTGGAATCAAAATTTGCTC
CATTTACTGCTATACATGGAGTACTTGTAGATATTTATGGTGTAGGTGTATTAATTATAGGTCAAAGTGGTGTAGGTAAA
AGTGAAACAGCGTTAGAACTAGTAAAAAGAGGTCATCGATTAGTTGCGGATGATAATGTAGAGATTCGACAAGAGGATTA
TGATAGTCTAATTGGAAATGCTCCTCCATTAATCGAGCATTTATTAGAGATCAGAGGTCTTGGTATTATTAATGTAATGA
CCTTATTTGGAGCTGGGTCCGTACGTAGTAAAAAACGAATTTCGTTAGTCATTAACCTTGAGAACTGGGATGAGAAAAAA
CAATATGATCGTCTTGGCTTGGATGAAGATATGATGAAAGTGATGGATGTTCATTTACCTAAAGCAACTGTACCAGTTCG
ACCAGGTAGAAACCTTGCAGTAATTATTGAAGTAGCTGCAATGAACTTTCGTCTAAAGCGAATGGGAGTCAATACAGCAG
AAGAATTCTCAGAAAGATTGTCTACCATGATTGAAAAAGGTGAGCTTGAATAG

Upstream 100 bases:

>100_bases
TTTATATAAACTATTGGAAACGTAGACTCTTGTCTACGTTTTTTCGTTTGACTATGCTAAAATGGTATTCAGTTATCAAG
GAATGGAAGGAGCTGCAATT

Downstream 100 bases:

>100_bases
AGGAGGAATAGACTATGCTACATACTGCGGCACCAATTGATAGAGTAGCTATTGAAATTGGCCCTCTTTCAATATATTGG
TATGGTATAATTATTGCATT

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P 1; HPr(Ser) kinase/phosphorylase 1

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MVAVVRTQDLLDNFNLTLVSGEDGIQREIITSDISRPGIEMTGYFRYYPKERLQLIGKTEMAYFLDLSSEQRRDRAERLC
TDITPGIVVSRGMDIPEELKEASEKSGVPILQSPRKTTRVISRLTNYLESKFAPFTAIHGVLVDIYGVGVLIIGQSGVGK
SETALELVKRGHRLVADDNVEIRQEDYDSLIGNAPPLIEHLLEIRGLGIINVMTLFGAGSVRSKKRISLVINLENWDEKK
QYDRLGLDEDMMKVMDVHLPKATVPVRPGRNLAVIIEVAAMNFRLKRMGVNTAEEFSERLSTMIEKGELE

Sequences:

>Translated_310_residues
MVAVVRTQDLLDNFNLTLVSGEDGIQREIITSDISRPGIEMTGYFRYYPKERLQLIGKTEMAYFLDLSSEQRRDRAERLC
TDITPGIVVSRGMDIPEELKEASEKSGVPILQSPRKTTRVISRLTNYLESKFAPFTAIHGVLVDIYGVGVLIIGQSGVGK
SETALELVKRGHRLVADDNVEIRQEDYDSLIGNAPPLIEHLLEIRGLGIINVMTLFGAGSVRSKKRISLVINLENWDEKK
QYDRLGLDEDMMKVMDVHLPKATVPVRPGRNLAVIIEVAAMNFRLKRMGVNTAEEFSERLSTMIEKGELE
>Mature_310_residues
MVAVVRTQDLLDNFNLTLVSGEDGIQREIITSDISRPGIEMTGYFRYYPKERLQLIGKTEMAYFLDLSSEQRRDRAERLC
TDITPGIVVSRGMDIPEELKEASEKSGVPILQSPRKTTRVISRLTNYLESKFAPFTAIHGVLVDIYGVGVLIIGQSGVGK
SETALELVKRGHRLVADDNVEIRQEDYDSLIGNAPPLIEHLLEIRGLGIINVMTLFGAGSVRSKKRISLVINLENWDEKK
QYDRLGLDEDMMKVMDVHLPKATVPVRPGRNLAVIIEVAAMNFRLKRMGVNTAEEFSERLSTMIEKGELE

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK1_OCEIH (Q8ENK1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693403.1
- ProteinModelPortal:   Q8ENK1
- SMR:   Q8ENK1
- GeneID:   1017185
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2482
- NMPDR:   fig|221109.1.peg.2481
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- BioCyc:   OIHE221109:OB2482-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 34832; Mature: 34832

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: ACT_SITE 139-139 ACT_SITE 160-160 ACT_SITE 178-178 ACT_SITE 244-244

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVVRTQDLLDNFNLTLVSGEDGIQREIITSDISRPGIEMTGYFRYYPKERLQLIGKTE
CEEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHCCCC
MAYFLDLSSEQRRDRAERLCTDITPGIVVSRGMDIPEELKEASEKSGVPILQSPRKTTRV
EEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
ISRLTNYLESKFAPFTAIHGVLVDIYGVGVLIIGQSGVGKSETALELVKRGHRLVADDNV
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCC
EIRQEDYDSLIGNAPPLIEHLLEIRGLGIINVMTLFGAGSVRSKKRISLVINLENWDEKK
EECHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHH
QYDRLGLDEDMMKVMDVHLPKATVPVRPGRNLAVIIEVAAMNFRLKRMGVNTAEEFSERL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCEEHHHCCCCCHHHHHHHH
STMIEKGELE
HHHHHHCCCC
>Mature Secondary Structure
MVAVVRTQDLLDNFNLTLVSGEDGIQREIITSDISRPGIEMTGYFRYYPKERLQLIGKTE
CEEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHCCCC
MAYFLDLSSEQRRDRAERLCTDITPGIVVSRGMDIPEELKEASEKSGVPILQSPRKTTRV
EEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
ISRLTNYLESKFAPFTAIHGVLVDIYGVGVLIIGQSGVGKSETALELVKRGHRLVADDNV
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCC
EIRQEDYDSLIGNAPPLIEHLLEIRGLGIINVMTLFGAGSVRSKKRISLVINLENWDEKK
EECHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHH
QYDRLGLDEDMMKVMDVHLPKATVPVRPGRNLAVIIEVAAMNFRLKRMGVNTAEEFSERL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCEEHHHCCCCCHHHHHHHH
STMIEKGELE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376