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The map label for this gene is trxB [H]

Identifier: 23099924

GI number: 23099924

Start: 2525898

End: 2526845

Strand: Reverse

Name: trxB [H]

Synonym: OB2469

Alternate gene names: 23099924

Gene position: 2526845-2525898 (Counterclockwise)

Preceding gene: 23099925

Following gene: 23099923

Centisome position: 69.6

GC content: 36.08

Gene sequence:

>948_bases
ATGTCCGAAGAAAAAATGTATGATGTAATCATTGCTGGAGCAGGTCCAGCAGGAATGACAGCAGCAGTATATGCATCACG
TGCAAATTTAGACACATTAATGTTAGAAAGAGGAATACCTGGTGGTCAAATGGCTAATACCGAGGATGTAGAGAACTATC
CAGGTTTTGATAATATACTAGGTCCAGATTTATCAAATAAAATGTTTGAGCATGCTAAAAAGTTCGGTGCAGCATATGCG
TATGGTGACATTAAGGAAGTAGAAGATCATGGAGAATATAAATTAATAAAAGCAGGTAGTAAAGAGTATTATACTCGCTC
TTTAATTATTGCAACTGGCGCTCAATATAAAAAGTTGGGAATTGAAGGCGAAGAAGCTCTTAGCGGTAGAGGTGTGTCTT
ATTGTGCAGTTTGTGACGGTGCATTCTTTAAAAATCGAAACCTTGTAGTAATTGGTGGAGGAGATTCAGCAGTTGAAGAA
GGCATTTACCTTACAAGGTTTGCCAATAAAGTAACTATCGTGCATCGAAGAGACAATCTTCGTGCTCAAAAGATCATACA
AGATCGTGCTTTTGACAATGAAAAAATAGATTTCATTTGGGATACTGTTGCAGAAACCATCAATGGCACTGATGGAAAAG
TAAGTAGTGTTACTTTGAAAAATACAAAAACAAATGAAGTAAATAATTTTGATGCTGAGGGTGTATTCATTTATATTGGA
ATGGTTCCTCTAAATCAGGCATTTCTTTCATTAGGAATTACAAATGATGAGGGATATATCGCAACAAATGAAAATATGGA
AACTTCCATTCCGGGAATATTTGCTGCAGGAGATATCCGAGATAAAGAACTTCGACAAATTGTTACAGCAACTGGAGATG
GCAGTATTGCTGCAGAAGCTGCAATAAAATATGTCGAAGATTTAGAGGAAAAGATAAAAAGTAAGTAA

Upstream 100 bases:

>100_bases
CCCTGGAATAATAAATAAGTAATGAGCAAAAAGATAGACGGATATCAATCGATTAATTAAACTAGATGATGGAATTAAAT
AGAATACGGGGGCGATTTAT

Downstream 100 bases:

>100_bases
TATTGGAGCAAATCTATAGAAAAATTTACCAATAGTAACTGCTTTTTAATCCTGCTGTAACACGCACGAAACATTTATGG
GGTACACTATAAATAACTAA

Product: thioredoxin reductase (NADPH)

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSEEKMYDVIIAGAGPAGMTAAVYASRANLDTLMLERGIPGGQMANTEDVENYPGFDNILGPDLSNKMFEHAKKFGAAYA
YGDIKEVEDHGEYKLIKAGSKEYYTRSLIIATGAQYKKLGIEGEEALSGRGVSYCAVCDGAFFKNRNLVVIGGGDSAVEE
GIYLTRFANKVTIVHRRDNLRAQKIIQDRAFDNEKIDFIWDTVAETINGTDGKVSSVTLKNTKTNEVNNFDAEGVFIYIG
MVPLNQAFLSLGITNDEGYIATNENMETSIPGIFAAGDIRDKELRQIVTATGDGSIAAEAAIKYVEDLEEKIKSK

Sequences:

>Translated_315_residues
MSEEKMYDVIIAGAGPAGMTAAVYASRANLDTLMLERGIPGGQMANTEDVENYPGFDNILGPDLSNKMFEHAKKFGAAYA
YGDIKEVEDHGEYKLIKAGSKEYYTRSLIIATGAQYKKLGIEGEEALSGRGVSYCAVCDGAFFKNRNLVVIGGGDSAVEE
GIYLTRFANKVTIVHRRDNLRAQKIIQDRAFDNEKIDFIWDTVAETINGTDGKVSSVTLKNTKTNEVNNFDAEGVFIYIG
MVPLNQAFLSLGITNDEGYIATNENMETSIPGIFAAGDIRDKELRQIVTATGDGSIAAEAAIKYVEDLEEKIKSK
>Mature_314_residues
SEEKMYDVIIAGAGPAGMTAAVYASRANLDTLMLERGIPGGQMANTEDVENYPGFDNILGPDLSNKMFEHAKKFGAAYAY
GDIKEVEDHGEYKLIKAGSKEYYTRSLIIATGAQYKKLGIEGEEALSGRGVSYCAVCDGAFFKNRNLVVIGGGDSAVEEG
IYLTRFANKVTIVHRRDNLRAQKIIQDRAFDNEKIDFIWDTVAETINGTDGKVSSVTLKNTKTNEVNNFDAEGVFIYIGM
VPLNQAFLSLGITNDEGYIATNENMETSIPGIFAAGDIRDKELRQIVTATGDGSIAAEAAIKYVEDLEEKIKSK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=295, Percent_Identity=26.7796610169492, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI65787454, Length=295, Percent_Identity=26.7796610169492, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI21389617, Length=295, Percent_Identity=26.7796610169492, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1787114, Length=320, Percent_Identity=40.3125, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI87081763, Length=319, Percent_Identity=31.974921630094, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320560, Length=315, Percent_Identity=40.9523809523809, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6321898, Length=323, Percent_Identity=39.3188854489164, Blast_Score=199, Evalue=5e-52,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34338; Mature: 34207

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEKMYDVIIAGAGPAGMTAAVYASRANLDTLMLERGIPGGQMANTEDVENYPGFDNIL
CCCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GPDLSNKMFEHAKKFGAAYAYGDIKEVEDHGEYKLIKAGSKEYYTRSLIIATGAQYKKLG
CCCHHHHHHHHHHHHCCEEECCCHHHHHCCCCEEEEECCCCHHEEEEEEEECCCCCEECC
IEGEEALSGRGVSYCAVCDGAFFKNRNLVVIGGGDSAVEEGIYLTRFANKVTIVHRRDNL
CCCHHHHCCCCCEEEEEECCCEECCCCEEEEECCCHHHHCCEEEEEECCEEEEEEECCCC
RAQKIIQDRAFDNEKIDFIWDTVAETINGTDGKVSSVTLKNTKTNEVNNFDAEGVFIYIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
MVPLNQAFLSLGITNDEGYIATNENMETSIPGIFAAGDIRDKELRQIVTATGDGSIAAEA
ECCCCCCHHEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHH
AIKYVEDLEEKIKSK
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEEKMYDVIIAGAGPAGMTAAVYASRANLDTLMLERGIPGGQMANTEDVENYPGFDNIL
CCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GPDLSNKMFEHAKKFGAAYAYGDIKEVEDHGEYKLIKAGSKEYYTRSLIIATGAQYKKLG
CCCHHHHHHHHHHHHCCEEECCCHHHHHCCCCEEEEECCCCHHEEEEEEEECCCCCEECC
IEGEEALSGRGVSYCAVCDGAFFKNRNLVVIGGGDSAVEEGIYLTRFANKVTIVHRRDNL
CCCHHHHCCCCCEEEEEECCCEECCCCEEEEECCCHHHHCCEEEEEECCEEEEEEECCCC
RAQKIIQDRAFDNEKIDFIWDTVAETINGTDGKVSSVTLKNTKTNEVNNFDAEGVFIYIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
MVPLNQAFLSLGITNDEGYIATNENMETSIPGIFAAGDIRDKELRQIVTATGDGSIAAEA
ECCCCCCHHEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHH
AIKYVEDLEEKIKSK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]