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The map label for this gene is coaE

Identifier: 23099616

GI number: 23099616

Start: 2193397

End: 2193996

Strand: Reverse

Name: coaE

Synonym: OB2161

Alternate gene names: 23099616

Gene position: 2193996-2193397 (Counterclockwise)

Preceding gene: 23099617

Following gene: 23099615

Centisome position: 60.43

GC content: 33.83

Gene sequence:

>600_bases
ATGACATTAGTTATTGGTTTAACAGGAGGAATAGCAAGTGGTAAAAGCACTGTCTCCTCCATGCTCCTTGAAAAAAACTT
TCCTGTAATTGATGCTGATCTAATTGCACGAGAAGTAGTAGAGCCAGGTGAAAAAGCATATGATCAAATTTTAGAAGCAT
TTGGGAAAGAAATCATCCAAAATGATCAAAAGATAGATCGACCCAAATTAGGATCAATTATTTTTACGGATGAAGATAAA
AGAAAGCAGTTAAATGCGATTGTTCATCCGGCTGTTCGGAATCGAATGCTAACCAAAAGAGATGATTATATTAACAATGA
CGTACCTTGTGTTATATTGGATATTCCTTTGTTATTTGAAAGTAACTTAGGTTATCTAGTTGATAAGACATTAGTTGTTT
ATGTAGATGAGGATATTCAACTTACCCGTTTGATGAAAAGAAATGAGTATAGTGAAAAAGAGGCTCTGGATCGAATAAAA
GCACAAATGTCTCTCAAGGAGAAAGCTGACTTAGCCGACATCGTTATTGATAATAATCAATCAGTTGAGGAGACCAAATT
ACAGTTAGATAACGTTCTACAAAAATGGAATATAAGTTAA

Upstream 100 bases:

>100_bases
CGTGTAGAGTTTGCGGCGCAGATATTATTAAAATAAAGGTTGGTGGAAGAGGCACTCATCTATGTCCTACTTGCCAGCCG
AATAAGCAAGGTGTGAGATA

Downstream 100 bases:

>100_bases
GTAATTTCACAAGAGTAACTGATGAGCTTTAAAACGTTCATCAGTTACTCTGTTTTATTTCAAGCATATATATTCAGCTC
ATAAGATATTATAATAACGT

Product: dephosphocoenzyme A kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTLVIGLTGGIASGKSTVSSMLLEKNFPVIDADLIAREVVEPGEKAYDQILEAFGKEIIQNDQKIDRPKLGSIIFTDEDK
RKQLNAIVHPAVRNRMLTKRDDYINNDVPCVILDIPLLFESNLGYLVDKTLVVYVDEDIQLTRLMKRNEYSEKEALDRIK
AQMSLKEKADLADIVIDNNQSVEETKLQLDNVLQKWNIS

Sequences:

>Translated_199_residues
MTLVIGLTGGIASGKSTVSSMLLEKNFPVIDADLIAREVVEPGEKAYDQILEAFGKEIIQNDQKIDRPKLGSIIFTDEDK
RKQLNAIVHPAVRNRMLTKRDDYINNDVPCVILDIPLLFESNLGYLVDKTLVVYVDEDIQLTRLMKRNEYSEKEALDRIK
AQMSLKEKADLADIVIDNNQSVEETKLQLDNVLQKWNIS
>Mature_198_residues
TLVIGLTGGIASGKSTVSSMLLEKNFPVIDADLIAREVVEPGEKAYDQILEAFGKEIIQNDQKIDRPKLGSIIFTDEDKR
KQLNAIVHPAVRNRMLTKRDDYINNDVPCVILDIPLLFESNLGYLVDKTLVVYVDEDIQLTRLMKRNEYSEKEALDRIKA
QMSLKEKADLADIVIDNNQSVEETKLQLDNVLQKWNIS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=189, Percent_Identity=45.5026455026455, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI191252795, Length=189, Percent_Identity=45.5026455026455, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI110227607, Length=195, Percent_Identity=29.2307692307692, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI110227605, Length=195, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI110227603, Length=195, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI110227601, Length=195, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI205277394, Length=195, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786292, Length=181, Percent_Identity=35.9116022099448, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17554944, Length=195, Percent_Identity=39.4871794871795, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25143409, Length=193, Percent_Identity=32.1243523316062, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=41.9191919191919, Blast_Score=150, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24644728, Length=187, Percent_Identity=43.8502673796791, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24658602, Length=194, Percent_Identity=32.9896907216495, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_OCEIH (Q8EPE7)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693082.1
- ProteinModelPortal:   Q8EPE7
- SMR:   Q8EPE7
- GeneID:   1017643
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2161
- NMPDR:   fig|221109.1.peg.2159
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- BioCyc:   OIHE221109:OB2161-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22575; Mature: 22444

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVIGLTGGIASGKSTVSSMLLEKNFPVIDADLIAREVVEPGEKAYDQILEAFGKEIIQ
CEEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NDQKIDRPKLGSIIFTDEDKRKQLNAIVHPAVRNRMLTKRDDYINNDVPCVILDIPLLFE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHC
SNLGYLVDKTLVVYVDEDIQLTRLMKRNEYSEKEALDRIKAQMSLKEKADLADIVIDNNQ
CCCCEEECCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
SVEETKLQLDNVLQKWNIS
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLVIGLTGGIASGKSTVSSMLLEKNFPVIDADLIAREVVEPGEKAYDQILEAFGKEIIQ
EEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NDQKIDRPKLGSIIFTDEDKRKQLNAIVHPAVRNRMLTKRDDYINNDVPCVILDIPLLFE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHC
SNLGYLVDKTLVVYVDEDIQLTRLMKRNEYSEKEALDRIKAQMSLKEKADLADIVIDNNQ
CCCCEEECCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
SVEETKLQLDNVLQKWNIS
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376