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The map label for this gene is ycgO [H]

Identifier: 23098806

GI number: 23098806

Start: 1395525

End: 1397015

Strand: Direct

Name: ycgO [H]

Synonym: OB1351

Alternate gene names: 23098806

Gene position: 1395525-1397015 (Clockwise)

Preceding gene: 23098805

Following gene: 23098807

Centisome position: 38.44

GC content: 36.69

Gene sequence:

>1491_bases
ATGTCTGAATTTACGTATCAATTTATTGCTATCGGATTATACTTTTTAGTTATGATAGCTATAGGACTATATTCATATCG
AAAAACGTCGAACTTAGACGATTATATGCTTGGAGGTAGAAGCTTAGGTCCAGTTACATCTGCACTAAGTGCTGGAGCTT
CAGATATGTCGCAATGGCTACTAATGGGTCTACCAGGAGCAATTTATTTATCTGGTCTTGCAGAAGGTTGGATTGCGATA
GGTTTAGCTATAGGGGCATGGTTGAATTGGTTAATTGTAGCACCAAGATTACGAACGTATACGGAAATATCTAATAACTC
GATTACAATTCCAAGCTATTTAGATAATCGTTTTAAAAACAACTCGAAGATCTTACGTATTGTTTCTGGCGCAGTTATAT
TAATTTACTTCACATTTTATGTTTCTTCAGGAATGGTAGCAGGTGGTGTTTTCTTTGAAAGCTCATTTAACTTTAATTAT
CATTCTGGTCTTATCGTAGTAGCAGTGGTTACTATTCTTTATACATTGCTAGGAGGATTCTTAGCTGTTAGTATTACTGA
TGTTGTGCAAGGGACGATGATGTTCTTGGCTCTAATTCTTGTACCGACGATGGCAATTTTCCATCTAGGAGGAGTTGGAG
AGACTGTAAACTTAATCCAAGATGTGGATCCTGATTTCTTAAGCTTTTTCGCAGCGGCGTCAACAACTGGTATTATTTCT
TCGCTTGCGTGGGGGCTAGGTTATTTTGGACAGCCACATATTATCGTTCGTTTCATGGCTATTAAATCAGTAAAAGAGAC
CACATCTGCACGTCGTATTGGAATGGGTTGGATGATAATTTCTCTAATCGGTGCCGTAATTACTGCACTAGTTGGTGTTG
CATTCTTCCATGCGAATCCAGAGTTTAACTTAGCTGATCCTGAAGCAGTATTTATTGTTCTAGGTCAAATATTATTCCAT
CCGTTCATTGCAGGTATATTATTAGCTGCTGTTATTGCAGCAATTATGAGTACAGTATCTTCTCAGTTACTAGTTACCTC
ATCTGCACTTGTGGAAGATATTTATAAAGCAGTTTTCAAATCAGATGCTTCAGATAAAACCTATGTAATTCTAAGTAGAT
TAGCTGTACTTCTAATTTCATTTATAGCGATTATATTTGCTTGGCAGAAGAATGATACTATATTAGGACTTGTATCATTT
GCATGGGCAGGATTCGGTGCTGCATTTGGTCCAGTTGTGTTACTTTCCTTATTCTGGAGAAAAACAACAGGAACCGGAGC
TTTATGGGGAATGATTGTTGGTGCAATTTCAGTATTCGTATGGGGTTATTCTCCGTTAGCCGACTATCTTTATGAACTTG
TTCCTGGTTTTATACTAAGTACAATTGTGATTGTTGTAGTAAGCTTACTTACGTATAAACCAAATCCAGAAGTGGAAAAA
GAATTTAATGAAACTGTTAAACGTCTAAAAGAGCATAAAAATAGATCTTGA

Upstream 100 bases:

>100_bases
GTAATAACAAATCAACTTTGGATTAGTACCGAAAGTACCACAAATTCCAAGTGTGAAAGCTTGTTATATATATATTAAAC
AAAGACGAAAGGGAGATAGG

Downstream 100 bases:

>100_bases
TAATAATTTTAATTAAAAGGCACCCGTTATCTTTCCGAGATAACGGATGCCTTTTATTGTAAGAAACTGACTCTAAAAAA
ATAAGTGGATTATCTAAGAA

Product: sodium:proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSEFTYQFIAIGLYFLVMIAIGLYSYRKTSNLDDYMLGGRSLGPVTSALSAGASDMSQWLLMGLPGAIYLSGLAEGWIAI
GLAIGAWLNWLIVAPRLRTYTEISNNSITIPSYLDNRFKNNSKILRIVSGAVILIYFTFYVSSGMVAGGVFFESSFNFNY
HSGLIVVAVVTILYTLLGGFLAVSITDVVQGTMMFLALILVPTMAIFHLGGVGETVNLIQDVDPDFLSFFAAASTTGIIS
SLAWGLGYFGQPHIIVRFMAIKSVKETTSARRIGMGWMIISLIGAVITALVGVAFFHANPEFNLADPEAVFIVLGQILFH
PFIAGILLAAVIAAIMSTVSSQLLVTSSALVEDIYKAVFKSDASDKTYVILSRLAVLLISFIAIIFAWQKNDTILGLVSF
AWAGFGAAFGPVVLLSLFWRKTTGTGALWGMIVGAISVFVWGYSPLADYLYELVPGFILSTIVIVVVSLLTYKPNPEVEK
EFNETVKRLKEHKNRS

Sequences:

>Translated_496_residues
MSEFTYQFIAIGLYFLVMIAIGLYSYRKTSNLDDYMLGGRSLGPVTSALSAGASDMSQWLLMGLPGAIYLSGLAEGWIAI
GLAIGAWLNWLIVAPRLRTYTEISNNSITIPSYLDNRFKNNSKILRIVSGAVILIYFTFYVSSGMVAGGVFFESSFNFNY
HSGLIVVAVVTILYTLLGGFLAVSITDVVQGTMMFLALILVPTMAIFHLGGVGETVNLIQDVDPDFLSFFAAASTTGIIS
SLAWGLGYFGQPHIIVRFMAIKSVKETTSARRIGMGWMIISLIGAVITALVGVAFFHANPEFNLADPEAVFIVLGQILFH
PFIAGILLAAVIAAIMSTVSSQLLVTSSALVEDIYKAVFKSDASDKTYVILSRLAVLLISFIAIIFAWQKNDTILGLVSF
AWAGFGAAFGPVVLLSLFWRKTTGTGALWGMIVGAISVFVWGYSPLADYLYELVPGFILSTIVIVVVSLLTYKPNPEVEK
EFNETVKRLKEHKNRS
>Mature_495_residues
SEFTYQFIAIGLYFLVMIAIGLYSYRKTSNLDDYMLGGRSLGPVTSALSAGASDMSQWLLMGLPGAIYLSGLAEGWIAIG
LAIGAWLNWLIVAPRLRTYTEISNNSITIPSYLDNRFKNNSKILRIVSGAVILIYFTFYVSSGMVAGGVFFESSFNFNYH
SGLIVVAVVTILYTLLGGFLAVSITDVVQGTMMFLALILVPTMAIFHLGGVGETVNLIQDVDPDFLSFFAAASTTGIISS
LAWGLGYFGQPHIIVRFMAIKSVKETTSARRIGMGWMIISLIGAVITALVGVAFFHANPEFNLADPEAVFIVLGQILFHP
FIAGILLAAVIAAIMSTVSSQLLVTSSALVEDIYKAVFKSDASDKTYVILSRLAVLLISFIAIIFAWQKNDTILGLVSFA
WAGFGAAFGPVVLLSLFWRKTTGTGALWGMIVGAISVFVWGYSPLADYLYELVPGFILSTIVIVVVSLLTYKPNPEVEKE
FNETVKRLKEHKNRS

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=497, Percent_Identity=51.5090543259557, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI110835708, Length=547, Percent_Identity=23.0347349177331, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI14140236, Length=541, Percent_Identity=23.4750462107209, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4507035, Length=381, Percent_Identity=23.0971128608924, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI206597487, Length=550, Percent_Identity=22.1818181818182, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4507033, Length=566, Percent_Identity=24.2049469964664, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI17941285, Length=478, Percent_Identity=23.4309623430962, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI206597483, Length=472, Percent_Identity=22.8813559322034, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI109659836, Length=536, Percent_Identity=22.5746268656716, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI11141885, Length=447, Percent_Identity=23.9373601789709, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787251, Length=488, Percent_Identity=51.844262295082, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI87082237, Length=436, Percent_Identity=27.9816513761468, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790503, Length=454, Percent_Identity=25.9911894273128, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790113, Length=520, Percent_Identity=22.5, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=411, Percent_Identity=22.6277372262774, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645928, Length=385, Percent_Identity=26.2337662337662, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221459584, Length=378, Percent_Identity=24.8677248677249, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221459588, Length=384, Percent_Identity=25, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640370, Length=414, Percent_Identity=24.3961352657005, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651739, Length=458, Percent_Identity=23.3624454148472, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221379702, Length=504, Percent_Identity=24.4047619047619, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221459586, Length=384, Percent_Identity=23.1770833333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648033, Length=395, Percent_Identity=23.0379746835443, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356865, Length=395, Percent_Identity=23.0379746835443, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573698, Length=457, Percent_Identity=22.3194748358862, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24651741, Length=475, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221459582, Length=404, Percent_Identity=23.5148514851485, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53903; Mature: 53772

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTYQFIAIGLYFLVMIAIGLYSYRKTSNLDDYMLGGRSLGPVTSALSAGASDMSQWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHH
LMGLPGAIYLSGLAEGWIAIGLAIGAWLNWLIVAPRLRTYTEISNNSITIPSYLDNRFKN
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEECCHHHHHHHCC
NSKILRIVSGAVILIYFTFYVSSGMVAGGVFFESSFNFNYHSGLIVVAVVTILYTLLGGF
CCHHHHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LAVSITDVVQGTMMFLALILVPTMAIFHLGGVGETVNLIQDVDPDFLSFFAAASTTGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
SLAWGLGYFGQPHIIVRFMAIKSVKETTSARRIGMGWMIISLIGAVITALVGVAFFHANP
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFNLADPEAVFIVLGQILFHPFIAGILLAAVIAAIMSTVSSQLLVTSSALVEDIYKAVFK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDASDKTYVILSRLAVLLISFIAIIFAWQKNDTILGLVSFAWAGFGAAFGPVVLLSLFWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTTGTGALWGMIVGAISVFVWGYSPLADYLYELVPGFILSTIVIVVVSLLTYKPNPEVEK
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
EFNETVKRLKEHKNRS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEFTYQFIAIGLYFLVMIAIGLYSYRKTSNLDDYMLGGRSLGPVTSALSAGASDMSQWL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHH
LMGLPGAIYLSGLAEGWIAIGLAIGAWLNWLIVAPRLRTYTEISNNSITIPSYLDNRFKN
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEECCHHHHHHHCC
NSKILRIVSGAVILIYFTFYVSSGMVAGGVFFESSFNFNYHSGLIVVAVVTILYTLLGGF
CCHHHHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LAVSITDVVQGTMMFLALILVPTMAIFHLGGVGETVNLIQDVDPDFLSFFAAASTTGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
SLAWGLGYFGQPHIIVRFMAIKSVKETTSARRIGMGWMIISLIGAVITALVGVAFFHANP
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFNLADPEAVFIVLGQILFHPFIAGILLAAVIAAIMSTVSSQLLVTSSALVEDIYKAVFK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDASDKTYVILSRLAVLLISFIAIIFAWQKNDTILGLVSFAWAGFGAAFGPVVLLSLFWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTTGTGALWGMIVGAISVFVWGYSPLADYLYELVPGFILSTIVIVVVSLLTYKPNPEVEK
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
EFNETVKRLKEHKNRS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]