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The map label for this gene is metA

Identifier: 23097893

GI number: 23097893

Start: 465350

End: 466261

Strand: Direct

Name: metA

Synonym: OB0438

Alternate gene names: 23097893

Gene position: 465350-466261 (Clockwise)

Preceding gene: 28563907

Following gene: 23097896

Centisome position: 12.82

GC content: 35.42

Gene sequence:

>912_bases
ATGCCAATTAAAATACCGATACACTTACCTGCAAAAGATATTTTAGAAAAAGAGAATATTTTTGTTATGGATGACCAACG
TGCTATTACACAAGATATCAGACCGCTGAATATATTAATCCTCAATTTAATGCCAGAAAAGCAAAAAACGGAAACGCAAT
TATTGCGTTTCTTAGGTAATACACCTCTGCAAGTTCATATTTCATTTTTACGAATGTCATCACACGAATCAAAGCATACG
AGTAAGTATCATCTAGATACTTTTTATAAGAAGTTTGAAGAAGTGAAATCGAAAAAGTTTGATGGAATGATTATTACTGG
ATCGCCAGTAGAACATTTGCCATTTGAAGAAGTAGATTATTGGAAAGAATTACAGGATATAATGAATTGGTCCAAAGAAA
ATGTTACATCAACATTGCACATTTGTTGGGGAGCACAAGCTGCGCTTTATCATCACTATGGTATTGATAAACATCACTTG
CCACAAAAATGTTTTGGCGTATATGAACATAAGCTGCTCCATCCACATGAACGTTTAGTACGGGGATTTGATGATTATTT
CTTTGCACCACATTCTCGATATACTGATGTTTCTATAAGTGAGATTGAAGCACACCCGGACCTTCAACTTTTAGCTAAAT
CGGATGATGCAGGTGTATTTTTGCTCGCTTCAAAAGATGGAAAACATATTATGGCGACGGGGCATCTCGAGTATAGTGCT
GAAACTTTAGCGGAGGAATATCTTCGTGATCATCAACGAGGTGTTGACACAGCTATTCCTGAAAATTATTTTCCAGACAA
CGATCCGAAAAAGCAACCGAAATATCGTTGGAAAAGTCATTGTAGTTTACTATTTTCTAATTGGTTAAATTATTATGTTT
ATCAAGAAACTCCTTATCAATGGGGGGAGTAG

Upstream 100 bases:

>100_bases
TAATTGTCCATAATTTTTAGATAAAATTTTCCGAATAGGGTTGAACTTTTCACGTGAGCCTTTACAATTAAAATTAACTT
AATTGTGGAGGGTACGACAG

Downstream 100 bases:

>100_bases
CATAGAAAAAGGCTTTCGAATTAATCGGAAGCCTTTTTGGTATGAGAAGTAATAAGCACGGGGTGCTGTTCTAGCGATGC
TTGTTCATAAGCTTCTACAA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MPIKIPIHLPAKDILEKENIFVMDDQRAITQDIRPLNILILNLMPEKQKTETQLLRFLGNTPLQVHISFLRMSSHESKHT
SKYHLDTFYKKFEEVKSKKFDGMIITGSPVEHLPFEEVDYWKELQDIMNWSKENVTSTLHICWGAQAALYHHYGIDKHHL
PQKCFGVYEHKLLHPHERLVRGFDDYFFAPHSRYTDVSISEIEAHPDLQLLAKSDDAGVFLLASKDGKHIMATGHLEYSA
ETLAEEYLRDHQRGVDTAIPENYFPDNDPKKQPKYRWKSHCSLLFSNWLNYYVYQETPYQWGE

Sequences:

>Translated_303_residues
MPIKIPIHLPAKDILEKENIFVMDDQRAITQDIRPLNILILNLMPEKQKTETQLLRFLGNTPLQVHISFLRMSSHESKHT
SKYHLDTFYKKFEEVKSKKFDGMIITGSPVEHLPFEEVDYWKELQDIMNWSKENVTSTLHICWGAQAALYHHYGIDKHHL
PQKCFGVYEHKLLHPHERLVRGFDDYFFAPHSRYTDVSISEIEAHPDLQLLAKSDDAGVFLLASKDGKHIMATGHLEYSA
ETLAEEYLRDHQRGVDTAIPENYFPDNDPKKQPKYRWKSHCSLLFSNWLNYYVYQETPYQWGE
>Mature_302_residues
PIKIPIHLPAKDILEKENIFVMDDQRAITQDIRPLNILILNLMPEKQKTETQLLRFLGNTPLQVHISFLRMSSHESKHTS
KYHLDTFYKKFEEVKSKKFDGMIITGSPVEHLPFEEVDYWKELQDIMNWSKENVTSTLHICWGAQAALYHHYGIDKHHLP
QKCFGVYEHKLLHPHERLVRGFDDYFFAPHSRYTDVSISEIEAHPDLQLLAKSDDAGVFLLASKDGKHIMATGHLEYSAE
TLAEEYLRDHQRGVDTAIPENYFPDNDPKKQPKYRWKSHCSLLFSNWLNYYVYQETPYQWGE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=299, Percent_Identity=52.1739130434783, Blast_Score=342, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_OCEIH (Q8ET26)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691359.1
- ProteinModelPortal:   Q8ET26
- SMR:   Q8ET26
- GeneID:   1015452
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0438
- NMPDR:   fig|221109.1.peg.444
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- BioCyc:   OIHE221109:OB0438-MONOMER
- BRENDA:   2.3.1.46
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35655; Mature: 35524

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKIPIHLPAKDILEKENIFVMDDQRAITQDIRPLNILILNLMPEKQKTETQLLRFLGN
CCEEEEEECCHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCC
TPLQVHISFLRMSSHESKHTSKYHLDTFYKKFEEVKSKKFDGMIITGSPVEHLPFEEVDY
CCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
WKELQDIMNWSKENVTSTLHICWGAQAALYHHYGIDKHHLPQKCFGVYEHKLLHPHERLV
HHHHHHHHCCCHHCHHEEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHH
RGFDDYFFAPHSRYTDVSISEIEAHPDLQLLAKSDDAGVFLLASKDGKHIMATGHLEYSA
HCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCCHHH
ETLAEEYLRDHQRGVDTAIPENYFPDNDPKKQPKYRWKSHCSLLFSNWLNYYVYQETPYQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCC
WGE
CCC
>Mature Secondary Structure 
PIKIPIHLPAKDILEKENIFVMDDQRAITQDIRPLNILILNLMPEKQKTETQLLRFLGN
CEEEEEECCHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCC
TPLQVHISFLRMSSHESKHTSKYHLDTFYKKFEEVKSKKFDGMIITGSPVEHLPFEEVDY
CCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
WKELQDIMNWSKENVTSTLHICWGAQAALYHHYGIDKHHLPQKCFGVYEHKLLHPHERLV
HHHHHHHHCCCHHCHHEEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHH
RGFDDYFFAPHSRYTDVSISEIEAHPDLQLLAKSDDAGVFLLASKDGKHIMATGHLEYSA
HCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCCHHH
ETLAEEYLRDHQRGVDTAIPENYFPDNDPKKQPKYRWKSHCSLLFSNWLNYYVYQETPYQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCC
WGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376