Click here to switch to the map view.

The map label for this gene is merA [H]

Identifier: 229918338

GI number: 229918338

Start: 2588676

End: 2589989

Strand: Reverse

Name: merA [H]

Synonym: EAT1b_2623

Alternate gene names: 229918338

Gene position: 2589989-2588676 (Counterclockwise)

Preceding gene: 229918341

Following gene: 229918321

Centisome position: 86.34

GC content: 52.59

Gene sequence:

>1314_bases
ATGAAACGATACGATGTCATCATTGTCGGTAGCGGTTCCGCCGCGAGCCAAGCCGCTTCCATTTTACGCGAAGCCGGTAA
AGAGATTGCCATCATTGAGAATTGGACGTTCGGGGGAACATGTCCTCAACGCGGATGTGACCCGAAGAAGATGCTTGCCG
AAGGAGCTGAACTTCTTGCTCGAGCGGAACAGATGCGCGAACTCGGCGTCGATGGAAGCCTATCCCTCGATTGGTCGTCC
TTTAAAAAGCGGATTGATGAATATCGCTTCTCGATTCCTACGACAAAAACACAACATTGGAACGAGATGAACATTGACTT
ATATCAAAGAGAGCCTCACTTTATCGATGAGGATTCCATCGTCATCGATGGTCACGAGCTCTCTGCCAATCAATTTTTAA
TCGCTACGGGTCAAACGCCCCGCCCTCTCGATATCCCAGGTGGCGAACTGGCGATTACGAGCGATGATGTGTTCGACCTC
GACGTCTTACCTGAATCGATTCACATTGTAGGCGCCGGGTATATCGCCTTTGAGTTTGCCCACATCTTTCGACGATTCGG
AAGTGACGTGACCCTTCTTATTCGTTCGCGTGCGTTGAAGGCATTCGACCCGAACGTCGTCCACCGGCTCATTGAGGAAT
CGAAGCGAATCGGCATCACCGTCCGACATGACGTCGAACCAACACGAATCGACGGCAACGTCTTGACGTTATCAGATGAC
TCTACCCTCGAAGGCGTGGTCCTTAACGCCACCGGGCGAATTCCAAGCATCGAGCGCCTCCGGCTTGAAGCGGCCAGTGT
CACAGCTGATCATCACGGTGTACACGTGAACGAGCATCTGCAAACAAGTAACCCGAATATATACGCCGCGGGCGACGTCG
CCAAAAGTCCCAATCCTGCGCTCACTCCATTCGCCGGTCAGGAAGGGCGTCTCGCCGCACTCAATATGCTTCACGGGAAT
ACACGGGCACTCCCCGAGCGTCCGGCCCCGACCATCGTCTATGCGACGCCGCCGATTGCTAAAGTCGGTCTTACGGTGGA
AGAAGCGGAAGCGGAGGGCATTGACTTCGATGTGAAAGAAACGGATATGTCGCACTTCCTCACCTATTCACGAATCAATG
ACTCAACCGCCTATTCGAAAGTGTTACTAAGTGCAGAAGGGCACGTCATCGGGGCTCATTTGATTGGTCACCATGCCCCT
GAACTCATCAACCTGTTCTCTTTCATTATACAGAACAAACTGTCGCATCAACACGTGAAGCACTTAGAAGTCGCCTATCC
GACGGCCGCCTCCGACCTGACCTATCTCATCTAA

Upstream 100 bases:

>100_bases
GCTTAATGTGGTCGCTATGACTCAATTCCATTCACCTCAGTTTAGCTTCCTCCTGGACGGGAAAAAGAGTGTGATATCTC
GTCAGAGGAGGTTTTATATT

Downstream 100 bases:

>100_bases
ACAAAAGACGGGACTCGCCTCGTGGCGAATCCCGTCTTTTACTTATTCGATTCCTTTATCCTTGTCTTCTTTCAGCGCGT
CTTGTAACGACTTCTCCCAA

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKRYDVIIVGSGSAASQAASILREAGKEIAIIENWTFGGTCPQRGCDPKKMLAEGAELLARAEQMRELGVDGSLSLDWSS
FKKRIDEYRFSIPTTKTQHWNEMNIDLYQREPHFIDEDSIVIDGHELSANQFLIATGQTPRPLDIPGGELAITSDDVFDL
DVLPESIHIVGAGYIAFEFAHIFRRFGSDVTLLIRSRALKAFDPNVVHRLIEESKRIGITVRHDVEPTRIDGNVLTLSDD
STLEGVVLNATGRIPSIERLRLEAASVTADHHGVHVNEHLQTSNPNIYAAGDVAKSPNPALTPFAGQEGRLAALNMLHGN
TRALPERPAPTIVYATPPIAKVGLTVEEAEAEGIDFDVKETDMSHFLTYSRINDSTAYSKVLLSAEGHVIGAHLIGHHAP
ELINLFSFIIQNKLSHQHVKHLEVAYPTAASDLTYLI

Sequences:

>Translated_437_residues
MKRYDVIIVGSGSAASQAASILREAGKEIAIIENWTFGGTCPQRGCDPKKMLAEGAELLARAEQMRELGVDGSLSLDWSS
FKKRIDEYRFSIPTTKTQHWNEMNIDLYQREPHFIDEDSIVIDGHELSANQFLIATGQTPRPLDIPGGELAITSDDVFDL
DVLPESIHIVGAGYIAFEFAHIFRRFGSDVTLLIRSRALKAFDPNVVHRLIEESKRIGITVRHDVEPTRIDGNVLTLSDD
STLEGVVLNATGRIPSIERLRLEAASVTADHHGVHVNEHLQTSNPNIYAAGDVAKSPNPALTPFAGQEGRLAALNMLHGN
TRALPERPAPTIVYATPPIAKVGLTVEEAEAEGIDFDVKETDMSHFLTYSRINDSTAYSKVLLSAEGHVIGAHLIGHHAP
ELINLFSFIIQNKLSHQHVKHLEVAYPTAASDLTYLI
>Mature_437_residues
MKRYDVIIVGSGSAASQAASILREAGKEIAIIENWTFGGTCPQRGCDPKKMLAEGAELLARAEQMRELGVDGSLSLDWSS
FKKRIDEYRFSIPTTKTQHWNEMNIDLYQREPHFIDEDSIVIDGHELSANQFLIATGQTPRPLDIPGGELAITSDDVFDL
DVLPESIHIVGAGYIAFEFAHIFRRFGSDVTLLIRSRALKAFDPNVVHRLIEESKRIGITVRHDVEPTRIDGNVLTLSDD
STLEGVVLNATGRIPSIERLRLEAASVTADHHGVHVNEHLQTSNPNIYAAGDVAKSPNPALTPFAGQEGRLAALNMLHGN
TRALPERPAPTIVYATPPIAKVGLTVEEAEAEGIDFDVKETDMSHFLTYSRINDSTAYSKVLLSAEGHVIGAHLIGHHAP
ELINLFSFIIQNKLSHQHVKHLEVAYPTAASDLTYLI

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=29.2841648590022, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=29.0948275862069, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI291045266, Length=471, Percent_Identity=27.3885350318471, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=27.816091954023, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=28.5057471264368, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=28.5057471264368, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=28.5057471264368, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=28.5057471264368, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI291045268, Length=464, Percent_Identity=25.8620689655172, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=26.797385620915, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789915, Length=426, Percent_Identity=29.5774647887324, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87082354, Length=449, Percent_Identity=28.9532293986637, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=24.6153846153846, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=27.0742358078603, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=27.7894736842105, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71983429, Length=369, Percent_Identity=32.520325203252, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=369, Percent_Identity=32.520325203252, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=26.1410788381743, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=26.3616557734205, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=25.9656652360515, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=26.2472885032538, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=22.8632478632479, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=29.0794979079498, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=29.0794979079498, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=29.0794979079498, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.7368421052632, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=26.1437908496732, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 48023; Mature: 48023

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYDVIIVGSGSAASQAASILREAGKEIAIIENWTFGGTCPQRGCDPKKMLAEGAELLA
CCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
RAEQMRELGVDGSLSLDWSSFKKRIDEYRFSIPTTKTQHWNEMNIDLYQREPHFIDEDSI
HHHHHHHHCCCCCEEECHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEECCCCEECCCCE
VIDGHELSANQFLIATGQTPRPLDIPGGELAITSDDVFDLDVLPESIHIVGAGYIAFEFA
EEECCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHH
HIFRRFGSDVTLLIRSRALKAFDPNVVHRLIEESKRIGITVRHDVEPTRIDGNVLTLSDD
HHHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCEEECCEEEEECCC
STLEGVVLNATGRIPSIERLRLEAASVTADHHGVHVNEHLQTSNPNIYAAGDVAKSPNPA
CCCCEEEEECCCCCCCHHHHEEEHHHEECCCCCEEECCCEECCCCCEEEECCCCCCCCCC
LTPFAGQEGRLAALNMLHGNTRALPERPAPTIVYATPPIAKVGLTVEEAEAEGIDFDVKE
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCHHHCCEEECCCCCCCCCCCCC
TDMSHFLTYSRINDSTAYSKVLLSAEGHVIGAHLIGHHAPELINLFSFIIQNKLSHQHVK
CCHHHHEEEECCCCCHHHHEEEEECCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HLEVAYPTAASDLTYLI
HEEEECCCCCCCCEEEC
>Mature Secondary Structure
MKRYDVIIVGSGSAASQAASILREAGKEIAIIENWTFGGTCPQRGCDPKKMLAEGAELLA
CCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
RAEQMRELGVDGSLSLDWSSFKKRIDEYRFSIPTTKTQHWNEMNIDLYQREPHFIDEDSI
HHHHHHHHCCCCCEEECHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEECCCCEECCCCE
VIDGHELSANQFLIATGQTPRPLDIPGGELAITSDDVFDLDVLPESIHIVGAGYIAFEFA
EEECCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHH
HIFRRFGSDVTLLIRSRALKAFDPNVVHRLIEESKRIGITVRHDVEPTRIDGNVLTLSDD
HHHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCEEECCEEEEECCC
STLEGVVLNATGRIPSIERLRLEAASVTADHHGVHVNEHLQTSNPNIYAAGDVAKSPNPA
CCCCEEEEECCCCCCCHHHHEEEHHHEECCCCCEEECCCEECCCCCEEEECCCCCCCCCC
LTPFAGQEGRLAALNMLHGNTRALPERPAPTIVYATPPIAKVGLTVEEAEAEGIDFDVKE
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCHHHCCEEECCCCCCCCCCCCC
TDMSHFLTYSRINDSTAYSKVLLSAEGHVIGAHLIGHHAPELINLFSFIIQNKLSHQHVK
CCHHHHEEEECCCCCHHHHEEEEECCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HLEVAYPTAASDLTYLI
HEEEECCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]