BacMap

Definition	Exiguobacterium sp. AT1b, complete genome.
Accession	NC_012673
Length	2,999,895

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The map label for this gene is yvgN [H]

Identifier: 229918271

GI number: 229918271

Start: 2514757

End: 2515590

Strand: Reverse

Name: yvgN [H]

Synonym: EAT1b_2554

Alternate gene names: 229918271

Gene position: 2515590-2514757 (Counterclockwise)

Preceding gene: 229918272

Following gene: 229918270

Centisome position: 83.86

GC content: 50.24

Gene sequence:

>834_bases
ATGGAATGGACGACGTTGAATAATGACGTCAAGATGCCGATGCTCGGGCTCGGTGTCTATAAGGTCGAAGATGGCGCAGT
GACGGTCGATACGGTCAAAGCTGCGCTCGATGCAGACTATCGATTGATTGATACGGCTGCGATTTATCAAAATGAAGAGA
GTGTCGGACAAGCGCTTCGTGAAGCAGGCATCCCACGGGAGGACGTCTTTGTGACGACAAAGCTTTGGAACGAGTTCCAC
GGATTTGACGAGGCGCTCCAAGCGTTCCAGGATAGCCTAGATCGGCTCGGTCTCGAATATGTCGACTTGTTCCTCATCCA
CTGGCCGATGCCTCGTTTCGGTAAATTCGTCGAAACGTACAAAGCACTCGAACAGTTGTATGAAGAAGGACGCGTCCGAG
CAATCGGAGTCTCGAACTTTGAGATCGAGCATTTGGAACAAATTATTCAATCATGCTCAATCGTCCCGGCCGTGAACCAG
GTCGAGATCCATCCATATTTGTCTCAGAAAGAACTGATTGCATTCTGCAAACGATATGACATCCAGATTCAAGCGTGGAG
TCCACTCATGAAAGGACGCGAAGCGCTCGAAGATGAGACGATCGTCAAGATTGCGAAGGCTCACGGCAAGTCGCCGGCCC
AAGTCATTTTGCGTTGGCACTTACAGAACGGCGTCGCCGTCATCCCAAAATCCGTCACACCGAGTCGAATCAAAGAAAAT
ATACAGGTATTCGACTTCACATTGACGAAAGAAGAGATGGCGGCCATCGATGCGCTCAATCGTGATGAGCGGACCGGCTC
CGACCCGAAAGAGATGCATAAAATCCATTACTGA

Upstream 100 bases:

>100_bases
ATTGTGATCAAGGCGCACGGGGAAAGCATCCGTCTGTAGTTTTTCCTTTCCCTTCATCCAAAATTTCGGTAACGTTATAG
ACGAGAGGGAGGGATTTTTT

Downstream 100 bases:

>100_bases
GGAGTGAATGACATGTTCAAAAAACTGGCTTCTGATTTGACTGGCTTCAGCGACATCGGTGAGGTGATCGACCCGTCCGA
TTTCGATAAGGCGGACTCGG

Product: 2,5-didehydrogluconate reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEWTTLNNDVKMPMLGLGVYKVEDGAVTVDTVKAALDADYRLIDTAAIYQNEESVGQALREAGIPREDVFVTTKLWNEFH
GFDEALQAFQDSLDRLGLEYVDLFLIHWPMPRFGKFVETYKALEQLYEEGRVRAIGVSNFEIEHLEQIIQSCSIVPAVNQ
VEIHPYLSQKELIAFCKRYDIQIQAWSPLMKGREALEDETIVKIAKAHGKSPAQVILRWHLQNGVAVIPKSVTPSRIKEN
IQVFDFTLTKEEMAAIDALNRDERTGSDPKEMHKIHY

Sequences:

>Translated_277_residues
MEWTTLNNDVKMPMLGLGVYKVEDGAVTVDTVKAALDADYRLIDTAAIYQNEESVGQALREAGIPREDVFVTTKLWNEFH
GFDEALQAFQDSLDRLGLEYVDLFLIHWPMPRFGKFVETYKALEQLYEEGRVRAIGVSNFEIEHLEQIIQSCSIVPAVNQ
VEIHPYLSQKELIAFCKRYDIQIQAWSPLMKGREALEDETIVKIAKAHGKSPAQVILRWHLQNGVAVIPKSVTPSRIKEN
IQVFDFTLTKEEMAAIDALNRDERTGSDPKEMHKIHY
>Mature_277_residues
MEWTTLNNDVKMPMLGLGVYKVEDGAVTVDTVKAALDADYRLIDTAAIYQNEESVGQALREAGIPREDVFVTTKLWNEFH
GFDEALQAFQDSLDRLGLEYVDLFLIHWPMPRFGKFVETYKALEQLYEEGRVRAIGVSNFEIEHLEQIIQSCSIVPAVNQ
VEIHPYLSQKELIAFCKRYDIQIQAWSPLMKGREALEDETIVKIAKAHGKSPAQVILRWHLQNGVAVIPKSVTPSRIKEN
IQVFDFTLTKEEMAAIDALNRDERTGSDPKEMHKIHY

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=43.298969072165, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=43.298969072165, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=42.320819112628, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=40.1315789473684, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI310109922, Length=281, Percent_Identity=40.5693950177936, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI310109920, Length=299, Percent_Identity=39.1304347826087, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI5453543, Length=299, Percent_Identity=39.1304347826087, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI45446745, Length=299, Percent_Identity=39.1304347826087, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4503285, Length=299, Percent_Identity=39.1304347826087, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI291291012, Length=268, Percent_Identity=40.6716417910448, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=41.7808219178082, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI24497583, Length=297, Percent_Identity=37.7104377104377, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI24497585, Length=295, Percent_Identity=39.3220338983051, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=39.1891891891892, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=37.8181818181818, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=36.231884057971, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=43.5064935064935, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI310109926, Length=111, Percent_Identity=40.5405405405405, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI207028673, Length=111, Percent_Identity=40.5405405405405, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=45.0381679389313, Blast_Score=260, Evalue=6e-71,
Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=39.6078431372549, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1788081, Length=273, Percent_Identity=32.6007326007326, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788070, Length=218, Percent_Identity=28.8990825688073, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87081735, Length=272, Percent_Identity=26.8382352941176, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787674, Length=269, Percent_Identity=24.907063197026, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48994888, Length=267, Percent_Identity=25.0936329588015, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71998625, Length=270, Percent_Identity=40.7407407407407, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17537077, Length=291, Percent_Identity=39.5189003436426, Blast_Score=210, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=39.8625429553265, Blast_Score=207, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17564128, Length=295, Percent_Identity=38.6440677966102, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=38.8278388278388, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17552492, Length=274, Percent_Identity=33.5766423357664, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17550248, Length=290, Percent_Identity=34.4827586206897, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=34.3434343434343, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=36.3970588235294, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17566692, Length=294, Percent_Identity=35.3741496598639, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562292, Length=270, Percent_Identity=34.4444444444444, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=34.4322344322344, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320576, Length=285, Percent_Identity=40, Blast_Score=215, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6324694, Length=291, Percent_Identity=40.5498281786942, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=37.1794871794872, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319625, Length=291, Percent_Identity=40.2061855670103, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6322556, Length=261, Percent_Identity=33.7164750957854, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=34.1549295774648, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325169, Length=306, Percent_Identity=24.8366013071895, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24663317, Length=289, Percent_Identity=40.8304498269896, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21356425, Length=288, Percent_Identity=39.2361111111111, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=36.7549668874172, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24657054, Length=301, Percent_Identity=37.2093023255814, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24662781, Length=275, Percent_Identity=43.6363636363636, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24662785, Length=270, Percent_Identity=43.7037037037037, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129731, Length=287, Percent_Identity=39.3728222996516, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=37.2013651877133, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=34.472049689441, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=35.7638888888889, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281366140, Length=254, Percent_Identity=35.4330708661417, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31650; Mature: 31650

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWTTLNNDVKMPMLGLGVYKVEDGAVTVDTVKAALDADYRLIDTAAIYQNEESVGQALR
CCCCCCCCCCCCCEEECEEEEECCCCEEHHHHHHHHCCCCCEEHHHHHHCCHHHHHHHHH
EAGIPREDVFVTTKLWNEFHGFDEALQAFQDSLDRLGLEYVDLFLIHWPMPRFGKFVETY
HCCCCHHHEEEEHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHH
KALEQLYEEGRVRAIGVSNFEIEHLEQIIQSCSIVPAVNQVEIHPYLSQKELIAFCKRYD
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC
IQIQAWSPLMKGREALEDETIVKIAKAHGKSPAQVILRWHLQNGVAVIPKSVTPSRIKEN
CEEEECCHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCC
IQVFDFTLTKEEMAAIDALNRDERTGSDPKEMHKIHY
CEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MEWTTLNNDVKMPMLGLGVYKVEDGAVTVDTVKAALDADYRLIDTAAIYQNEESVGQALR
CCCCCCCCCCCCCEEECEEEEECCCCEEHHHHHHHHCCCCCEEHHHHHHCCHHHHHHHHH
EAGIPREDVFVTTKLWNEFHGFDEALQAFQDSLDRLGLEYVDLFLIHWPMPRFGKFVETY
HCCCCHHHEEEEHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHH
KALEQLYEEGRVRAIGVSNFEIEHLEQIIQSCSIVPAVNQVEIHPYLSQKELIAFCKRYD
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC
IQIQAWSPLMKGREALEDETIVKIAKAHGKSPAQVILRWHLQNGVAVIPKSVTPSRIKEN
CEEEECCHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCC
IQVFDFTLTKEEMAAIDALNRDERTGSDPKEMHKIHY
CEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]