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The map label for this gene is fhs [H]

Identifier: 229918043

GI number: 229918043

Start: 2274098

End: 2275783

Strand: Reverse

Name: fhs [H]

Synonym: EAT1b_2322

Alternate gene names: 229918043

Gene position: 2275783-2274098 (Counterclockwise)

Preceding gene: 229918068

Following gene: 229918042

Centisome position: 75.86

GC content: 50.42

Gene sequence:

>1686_bases
ATGACAACGACGAAACCATTATCTGACCTTACGATTGCCCAACAAGCCAAAACCTTGCCGATTAAAGACATCGCAGCAAA
AATCGGATTACACGAAGATGACCTGGATCTTTACGGAAAATACAAAGCGAAACTTTCTTACGATGTCCTCGAACGTGTGA
AAACGAAGGAAGACGGAAAACTCGTTCTCGTCACCGCCATCAATCCGACACCAGCTGGCGAAGGAAAATCGACGGTGACG
GTCGGGCTCGGACAGGCGTTGAACCAATTGGATAAACAAGCGATCGTCTGTCTGCGCGAACCTTCGCTCGGTCCGACGAT
GGGCTTAAAAGGTGGCGCTGCTGGTGGTGGCTTCAGTCAAGTTCTCCCGATGGAAGATATCAACCTTCACTTCACAGGTG
ACATGCATGCGATCACATCGGCCCATAATACGATCAGTGCCATGATTGACAATCACTTGCACCAAGGAAACGACCTTGGG
ATCGATGTCCGACATATTGTCTGGAAGCGCGTCCTTGACTTAAACGACCGCGCACTTCGTCACGTCACGGTCGGCCTCGG
TGGTCCTGCTCACGGAGTCCCTCGTGAGGACGGATTTGATATTACCGTCGCTTCGGAAATCATGGCGATTCTCTGTCTGG
CCGATTCATTGGAAGACCTCGAAGAACGCATCAAGCGTATCGTAGTCGCCTATGACCATCAAAAAGAACCAATCACGGCA
GAACAAATCGGTGCAGCCGGTGCGGCGACGTTACTGTTGAAGGAAGCCTTTAAACCGAACCTCGTCCAAACGCTTGAACA
GACACCAGCACTCGTCCACGGCGGGCCGTTCGCGAACATTGCGCACGGATGCAACTCATTGATTGCAACGAAGACTGCGT
TAAAGCTTGGGGAGTATGTGGTGACGGAAGCTGGGTTTGGTGCCGACCTCGGGGCAGAAAAGTTCTGTCATATCAAATCT
CGAGTCGGTGATTTGAATCCGGATGCGGTCGTACTCGTTGCAACCGTTCGTGCTCTAAAAATGCACGGTGGCGTTTCAAA
AGATCAGCTTCACATCGAGAACGTCGGTGCGGTCGGCGAAGGATTAAAATTACTCGCCAAACACATCGATACGATGAAAA
AACTCGGTCTGCCTACGGTCGTCGCATTGAACCGTTTCAATTCAGATACAGAAGAGGAACTTGCAACCGTTCTTGATTGG
TGTGCGGCACACGGTATTCGTGCTTCGCTCAGCGAAGTATGGGCAAACGGCGGGCTTGGGGGTCGACAATTGGCCGAAGC
AGTCATTGACGCCGTCGAGTCGAACGAAAGTAAACTGACGCCTCTATATGAGTTGACCGATTCAATTGAACAAAAGATTA
AAACCATTGCGAGAGAAGTATACGGTGCTACAGACGTCGTGTTCACCGCCAAAGCTCAAAAGCAAATGAAAGATGTACAG
GCGAACGGCTGGTCGGACCTTCCCATTTGTATGGCGAAGACACCGTTCTCCCTCTCAGACGACCCTTCAAAATTCGGTTA
TCAACAAGGATTCACCATCACCGTTCGCGAATTAAAACCTTCAGTGGGAGCAGGATTCCTCGTCGCCTTAACTGGCAACG
TGTTAACGATGCCAGGGTTACCGAAACATCCAGCGGCTCTCAATATGGGAATTGACGAATCTGGAAAAGCAATCGGCCTT
TTCTAA

Upstream 100 bases:

>100_bases
ATTGAATATGTTTAGCCTTGATTCATATTTTAATCCGAAATTCCCGAATGATTTTTAGAGATTAAAAAGATATCGTTCGA
CAAACGGAGGGACTTTTTGA

Downstream 100 bases:

>100_bases
TAGGGGGATGACACATGATCGTATCGGAGTTGACGTATCCTGACGGGTATCAAACAGAAGTCATGCACGTTCAGGCAGAG
CAATCGATTGGAAAAATATT

Product: Formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MTTTKPLSDLTIAQQAKTLPIKDIAAKIGLHEDDLDLYGKYKAKLSYDVLERVKTKEDGKLVLVTAINPTPAGEGKSTVT
VGLGQALNQLDKQAIVCLREPSLGPTMGLKGGAAGGGFSQVLPMEDINLHFTGDMHAITSAHNTISAMIDNHLHQGNDLG
IDVRHIVWKRVLDLNDRALRHVTVGLGGPAHGVPREDGFDITVASEIMAILCLADSLEDLEERIKRIVVAYDHQKEPITA
EQIGAAGAATLLLKEAFKPNLVQTLEQTPALVHGGPFANIAHGCNSLIATKTALKLGEYVVTEAGFGADLGAEKFCHIKS
RVGDLNPDAVVLVATVRALKMHGGVSKDQLHIENVGAVGEGLKLLAKHIDTMKKLGLPTVVALNRFNSDTEEELATVLDW
CAAHGIRASLSEVWANGGLGGRQLAEAVIDAVESNESKLTPLYELTDSIEQKIKTIAREVYGATDVVFTAKAQKQMKDVQ
ANGWSDLPICMAKTPFSLSDDPSKFGYQQGFTITVRELKPSVGAGFLVALTGNVLTMPGLPKHPAALNMGIDESGKAIGL
F

Sequences:

>Translated_561_residues
MTTTKPLSDLTIAQQAKTLPIKDIAAKIGLHEDDLDLYGKYKAKLSYDVLERVKTKEDGKLVLVTAINPTPAGEGKSTVT
VGLGQALNQLDKQAIVCLREPSLGPTMGLKGGAAGGGFSQVLPMEDINLHFTGDMHAITSAHNTISAMIDNHLHQGNDLG
IDVRHIVWKRVLDLNDRALRHVTVGLGGPAHGVPREDGFDITVASEIMAILCLADSLEDLEERIKRIVVAYDHQKEPITA
EQIGAAGAATLLLKEAFKPNLVQTLEQTPALVHGGPFANIAHGCNSLIATKTALKLGEYVVTEAGFGADLGAEKFCHIKS
RVGDLNPDAVVLVATVRALKMHGGVSKDQLHIENVGAVGEGLKLLAKHIDTMKKLGLPTVVALNRFNSDTEEELATVLDW
CAAHGIRASLSEVWANGGLGGRQLAEAVIDAVESNESKLTPLYELTDSIEQKIKTIAREVYGATDVVFTAKAQKQMKDVQ
ANGWSDLPICMAKTPFSLSDDPSKFGYQQGFTITVRELKPSVGAGFLVALTGNVLTMPGLPKHPAALNMGIDESGKAIGL
F
>Mature_560_residues
TTTKPLSDLTIAQQAKTLPIKDIAAKIGLHEDDLDLYGKYKAKLSYDVLERVKTKEDGKLVLVTAINPTPAGEGKSTVTV
GLGQALNQLDKQAIVCLREPSLGPTMGLKGGAAGGGFSQVLPMEDINLHFTGDMHAITSAHNTISAMIDNHLHQGNDLGI
DVRHIVWKRVLDLNDRALRHVTVGLGGPAHGVPREDGFDITVASEIMAILCLADSLEDLEERIKRIVVAYDHQKEPITAE
QIGAAGAATLLLKEAFKPNLVQTLEQTPALVHGGPFANIAHGCNSLIATKTALKLGEYVVTEAGFGADLGAEKFCHIKSR
VGDLNPDAVVLVATVRALKMHGGVSKDQLHIENVGAVGEGLKLLAKHIDTMKKLGLPTVVALNRFNSDTEEELATVLDWC
AAHGIRASLSEVWANGGLGGRQLAEAVIDAVESNESKLTPLYELTDSIEQKIKTIAREVYGATDVVFTAKAQKQMKDVQA
NGWSDLPICMAKTPFSLSDDPSKFGYQQGFTITVRELKPSVGAGFLVALTGNVLTMPGLPKHPAALNMGIDESGKAIGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=45.0726978998384, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=45.2342487883683, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI310124614, Length=88, Percent_Identity=40.9090909090909, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=44.5337620578778, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=44.5337620578778, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319558, Length=634, Percent_Identity=41.7981072555205, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.1309904153355, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=43.2258064516129, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=43.2258064516129, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=43.2258064516129, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=43.2258064516129, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59844; Mature: 59712

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTKPLSDLTIAQQAKTLPIKDIAAKIGLHEDDLDLYGKYKAKLSYDVLERVKTKEDGK
CCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCC
LVLVTAINPTPAGEGKSTVTVGLGQALNQLDKQAIVCLREPSLGPTMGLKGGAAGGGFSQ
EEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCHH
VLPMEDINLHFTGDMHAITSAHNTISAMIDNHLHQGNDLGIDVRHIVWKRVLDLNDRALR
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEE
HVTVGLGGPAHGVPREDGFDITVASEIMAILCLADSLEDLEERIKRIVVAYDHQKEPITA
EEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCH
EQIGAAGAATLLLKEAFKPNLVQTLEQTPALVHGGPFANIAHGCNSLIATKTALKLGEYV
HHHCCCHHHHHHHHHHCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VTEAGFGADLGAEKFCHIKSRVGDLNPDAVVLVATVRALKMHGGVSKDQLHIENVGAVGE
EECCCCCCCCCHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEECCCCCHHH
GLKLLAKHIDTMKKLGLPTVVALNRFNSDTEEELATVLDWCAAHGIRASLSEVWANGGLG
HHHHHHHHHHHHHHCCCCCEEEEHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GRQLAEAVIDAVESNESKLTPLYELTDSIEQKIKTIAREVYGATDVVFTAKAQKQMKDVQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
ANGWSDLPICMAKTPFSLSDDPSKFGYQQGFTITVRELKPSVGAGFLVALTGNVLTMPGL
CCCCCCCCEEEECCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCC
PKHPAALNMGIDESGKAIGLF
CCCCCEEECCCCCCCCEECCC
>Mature Secondary Structure 
TTTKPLSDLTIAQQAKTLPIKDIAAKIGLHEDDLDLYGKYKAKLSYDVLERVKTKEDGK
CCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCC
LVLVTAINPTPAGEGKSTVTVGLGQALNQLDKQAIVCLREPSLGPTMGLKGGAAGGGFSQ
EEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCHH
VLPMEDINLHFTGDMHAITSAHNTISAMIDNHLHQGNDLGIDVRHIVWKRVLDLNDRALR
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEE
HVTVGLGGPAHGVPREDGFDITVASEIMAILCLADSLEDLEERIKRIVVAYDHQKEPITA
EEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCH
EQIGAAGAATLLLKEAFKPNLVQTLEQTPALVHGGPFANIAHGCNSLIATKTALKLGEYV
HHHCCCHHHHHHHHHHCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VTEAGFGADLGAEKFCHIKSRVGDLNPDAVVLVATVRALKMHGGVSKDQLHIENVGAVGE
EECCCCCCCCCHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEECCCCCHHH
GLKLLAKHIDTMKKLGLPTVVALNRFNSDTEEELATVLDWCAAHGIRASLSEVWANGGLG
HHHHHHHHHHHHHHCCCCCEEEEHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GRQLAEAVIDAVESNESKLTPLYELTDSIEQKIKTIAREVYGATDVVFTAKAQKQMKDVQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
ANGWSDLPICMAKTPFSLSDDPSKFGYQQGFTITVRELKPSVGAGFLVALTGNVLTMPGL
CCCCCCCCEEEECCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCC
PKHPAALNMGIDESGKAIGLF
CCCCCEEECCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA