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The map label for this gene is hemY [H]

Identifier: 229917970

GI number: 229917970

Start: 2203348

End: 2204712

Strand: Reverse

Name: hemY [H]

Synonym: EAT1b_2249

Alternate gene names: 229917970

Gene position: 2204712-2203348 (Counterclockwise)

Preceding gene: 229917973

Following gene: 229917969

Centisome position: 73.49

GC content: 51.43

Gene sequence:

>1365_bases
GTGAATCAATTGAATCGTATCGCGATTATTGGAGGAGGCATCACCGGACTTGCCGCAGCCTATTATGCCAAAGAAGCCGG
AGCTCATGTCACATTGATCGAGGCGCAGGACCGTCTCGGTGGAAAAATTAAGACCATTTATCGGGATGGGTTTACGTTAG
AGACTGGACCCGACGGTTATATGGCACGGAAGCCGACCTTGACATCACTTATTACGGATCTCGGTCTCGCAGATCAACTC
GTCCGCTCCAGAACCGGGACTTCTTACATTTACGTACGGAAGCAACTGAGACAGATGCCGGCCGGATCGGTCATGGGCAT
CCCGACCAAGTTTTGGCCGATGGTCAAAACGGATCTCTTTACTTGGAGAGGAAAACTTCGCGCCGGATTCGATCTCGTGA
TTCCACGCGTGTATGCAGGAGAGGATATCTCGCTCGACCGTTTCTTTCGGACGAGACTCGGCTCAGAAGTCGTCGATACG
ATGATCGAACCGCTTCTGTCCGGGATTTACAACGGGACACTCGAAGACATGAGCATCGAGTCTACTTTCCCTCAGTTTAT
CACGATTGAACAAAAAACTCGCAGTCTGATTCTCGGAATGAAAGCACTCACCCCTCCCGTCCAAGCTGGTGTAAAGCCGT
CCGAGACTGGTAAGTTCCTGTCAATCGAGCAAGGACTCGGAGCACTCGTCGAGGCGCTCCGTCCGTCGATCGATCGACTC
ATGTTAAAGACGCTTGTTCAATCCGTTCGACCTCATGAAGTCACATTTGCCGATGGGACGGTCGAACAGTTTGACGGCAT
CATTCTTGCGACTTCTCCTCAAGCACTCGGACCTTTGCTCGGATTCCCAGAAGCCGAACGCTTGTCATCGTTAAAATGTA
CCTCTTCGATGACCGTACTCGCCGCCTTCGACGAGTCAGATGTAGATGCGTTAGATGGAACCGGCTACGTCATCGCCAAA
TCGGAAGGAAACGCCTTGACCGCTTGTAGCTGGATGCATAAAAAATGGCCACACCTAGCACCTAAAAGAAAAGCATTGCT
CCGCATGTATATCGGTTCAGAACATGTCCCGTCCCTGCTCCATGAAGAGGATGATCAAATCGCAAACTTCGCTTTAAGCG
AACTTCGACGCATTCAAAAAGTCGGGACTCCCCTCTTCACGAAAGTCGAACGACACATTCAAACGATGCCACAATATGAA
GTCGGTCATAAACAGGACGTCCGCGCGTTCGAAGAAGCACTTCTGAAGTGGGACGGCGTCGAGGCGTGTGGTGCCATACT
TCATGGAGTCGGATTACCTGACTGCGTCGATTCTGCCAAACGGGCGGTCGATCACTTACATCTTCGACAGGCGGTGACGG
TATGA

Upstream 100 bases:

>100_bases
CGAATTCGTGACAAATTTGTCTAGAACTCCGTGACACTTATCCTATATCTCCGTCAACATTCTCGGTACCGTTAAGACGA
CAACAACTTTAGAGAAATGG

Downstream 100 bases:

>100_bases
AACACATCGACTATAACGAAAATCCGTTCATCGTCATTTGGGAAGTCACACGGGCCTGTGCGCTCTCCTGCGTCCACTGC
CGGGCAGAGGCACAATTTCA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNQLNRIAIIGGGITGLAAAYYAKEAGAHVTLIEAQDRLGGKIKTIYRDGFTLETGPDGYMARKPTLTSLITDLGLADQL
VRSRTGTSYIYVRKQLRQMPAGSVMGIPTKFWPMVKTDLFTWRGKLRAGFDLVIPRVYAGEDISLDRFFRTRLGSEVVDT
MIEPLLSGIYNGTLEDMSIESTFPQFITIEQKTRSLILGMKALTPPVQAGVKPSETGKFLSIEQGLGALVEALRPSIDRL
MLKTLVQSVRPHEVTFADGTVEQFDGIILATSPQALGPLLGFPEAERLSSLKCTSSMTVLAAFDESDVDALDGTGYVIAK
SEGNALTACSWMHKKWPHLAPKRKALLRMYIGSEHVPSLLHEEDDQIANFALSELRRIQKVGTPLFTKVERHIQTMPQYE
VGHKQDVRAFEEALLKWDGVEACGAILHGVGLPDCVDSAKRAVDHLHLRQAVTV

Sequences:

>Translated_454_residues
MNQLNRIAIIGGGITGLAAAYYAKEAGAHVTLIEAQDRLGGKIKTIYRDGFTLETGPDGYMARKPTLTSLITDLGLADQL
VRSRTGTSYIYVRKQLRQMPAGSVMGIPTKFWPMVKTDLFTWRGKLRAGFDLVIPRVYAGEDISLDRFFRTRLGSEVVDT
MIEPLLSGIYNGTLEDMSIESTFPQFITIEQKTRSLILGMKALTPPVQAGVKPSETGKFLSIEQGLGALVEALRPSIDRL
MLKTLVQSVRPHEVTFADGTVEQFDGIILATSPQALGPLLGFPEAERLSSLKCTSSMTVLAAFDESDVDALDGTGYVIAK
SEGNALTACSWMHKKWPHLAPKRKALLRMYIGSEHVPSLLHEEDDQIANFALSELRRIQKVGTPLFTKVERHIQTMPQYE
VGHKQDVRAFEEALLKWDGVEACGAILHGVGLPDCVDSAKRAVDHLHLRQAVTV
>Mature_454_residues
MNQLNRIAIIGGGITGLAAAYYAKEAGAHVTLIEAQDRLGGKIKTIYRDGFTLETGPDGYMARKPTLTSLITDLGLADQL
VRSRTGTSYIYVRKQLRQMPAGSVMGIPTKFWPMVKTDLFTWRGKLRAGFDLVIPRVYAGEDISLDRFFRTRLGSEVVDT
MIEPLLSGIYNGTLEDMSIESTFPQFITIEQKTRSLILGMKALTPPVQAGVKPSETGKFLSIEQGLGALVEALRPSIDRL
MLKTLVQSVRPHEVTFADGTVEQFDGIILATSPQALGPLLGFPEAERLSSLKCTSSMTVLAAFDESDVDALDGTGYVIAK
SEGNALTACSWMHKKWPHLAPKRKALLRMYIGSEHVPSLLHEEDDQIANFALSELRRIQKVGTPLFTKVERHIQTMPQYE
VGHKQDVRAFEEALLKWDGVEACGAILHGVGLPDCVDSAKRAVDHLHLRQAVTV

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=474, Percent_Identity=26.3713080168776, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4506001, Length=474, Percent_Identity=26.3713080168776, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 49949; Mature: 49949

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLNRIAIIGGGITGLAAAYYAKEAGAHVTLIEAQDRLGGKIKTIYRDGFTLETGPDGY
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCEEEEEEECCEEECCCCCCC
MARKPTLTSLITDLGLADQLVRSRTGTSYIYVRKQLRQMPAGSVMGIPTKFWPMVKTDLF
EECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHH
TWRGKLRAGFDLVIPRVYAGEDISLDRFFRTRLGSEVVDTMIEPLLSGIYNGTLEDMSIE
HHHCCCCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
STFPQFITIEQKTRSLILGMKALTPPVQAGVKPSETGKFLSIEQGLGALVEALRPSIDRL
CCCCCEEEEHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
MLKTLVQSVRPHEVTFADGTVEQFDGIILATSPQALGPLLGFPEAERLSSLKCTSSMTVL
HHHHHHHHCCCCEEEECCCCHHHHCCEEEEECCHHHHHHCCCCCHHHHHHHHHCCCEEEE
AAFDESDVDALDGTGYVIAKSEGNALTACSWMHKKWPHLAPKRKALLRMYIGSEHVPSLL
EEECCCCCCCCCCCCEEEEECCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHH
HEEDDQIANFALSELRRIQKVGTPLFTKVERHIQTMPQYEVGHKQDVRAFEEALLKWDGV
HCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
EACGAILHGVGLPDCVDSAKRAVDHLHLRQAVTV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQLNRIAIIGGGITGLAAAYYAKEAGAHVTLIEAQDRLGGKIKTIYRDGFTLETGPDGY
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCEEEEEEECCEEECCCCCCC
MARKPTLTSLITDLGLADQLVRSRTGTSYIYVRKQLRQMPAGSVMGIPTKFWPMVKTDLF
EECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHH
TWRGKLRAGFDLVIPRVYAGEDISLDRFFRTRLGSEVVDTMIEPLLSGIYNGTLEDMSIE
HHHCCCCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
STFPQFITIEQKTRSLILGMKALTPPVQAGVKPSETGKFLSIEQGLGALVEALRPSIDRL
CCCCCEEEEHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
MLKTLVQSVRPHEVTFADGTVEQFDGIILATSPQALGPLLGFPEAERLSSLKCTSSMTVL
HHHHHHHHCCCCEEEECCCCHHHHCCEEEEECCHHHHHHCCCCCHHHHHHHHHCCCEEEE
AAFDESDVDALDGTGYVIAKSEGNALTACSWMHKKWPHLAPKRKALLRMYIGSEHVPSLL
EEECCCCCCCCCCCCEEEEECCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHH
HEEDDQIANFALSELRRIQKVGTPLFTKVERHIQTMPQYEVGHKQDVRAFEEALLKWDGV
HCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
EACGAILHGVGLPDCVDSAKRAVDHLHLRQAVTV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]