Definition Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome.
Accession NC_004631
Length 4,791,961

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The map label for this gene is mrcA [H]

Identifier: 229220623

GI number: 229220623

Start: 4166037

End: 4168589

Strand: Reverse

Name: mrcA [H]

Synonym: t4013

Alternate gene names: 229220623

Gene position: 4168589-4166037 (Counterclockwise)

Preceding gene: 29144294

Following gene: 29144279

Centisome position: 86.99

GC content: 56.6

Gene sequence:

>2553_bases
GTGAAGTTCGTAAAGTATTTATTGATCCTTGCAGTATGTTGCATCCTGCTGGGAGCAGGCTCGATTTATGGCCTTTATCG
CTATATTGAGCCGCAGCTACCTGACGTCGCGACATTGAAAGATGTGCGTTTACAAATTCCGATGCAGGTTTACAGCGCGG
ATGGCGAACTTATCGCGCAATATGGCGAAAAACGCCGTATTCCCGTTACGCTCGATCAAATTCCGCCGGAAATGATCAAC
GCCTTTATCGCCACCGAAGATAGCCGCTTTTATGAGCATCACGGTATTGACCCGGTAGGTATTTTCCGTGCGGCCAGCGT
CGCGCTCTTCTCCGGTCACGCATCGCAGGGAGCAAGTACCATTACCCAGCAACTGGCGCGAAACTTCTTCCTTAGCCCCG
AACGCACGCTGATGCGCAAGATCAAGGAAGCGTTTCTGGCGATTCGTATTGAGCAGTTGCTGAATAAAAATGAGATCCTC
GAACTCTATCTGAACAAGATCTATCTCGGCTACCGCGCCTATGGCGTTGGCGCGGCGGCACAGGTCTACTTTGGTAAGAC
GGTCGACCAGCTTAGTTTAAGCGAAATGGCGGTTATCGCCGGGCTACCTAAAGCGCCTTCTACCTTTAACCCGCTCTACT
CGATGGATCGGGCGGTGGCGCGCCGTAACGTAGTGCTCTCACGAATGTTAAGCGAGGGATATATCACTCAGGCGCAGTAC
GATCAGGCCCGTAGCGAACCTATCGACGCAAATTATCACGCGCCGGAAATCGCCTTCTCCGCGCCTTATCTGTCGGAAAT
GGTGCGCCAGGAAATGTATAACCGTTATGGCGAAAGCGCCTATGAAGATGGTTATCGTATTTACACGACCATCACCCGCA
AAGTGCAGCAGGCCGCGCAACAGGCGGTGCGTAATAACGTGCTGGACTATGACATGCGCCACGGTTATAGCGGCCCGGCG
AATGTGCTATGGAAAGTGGGCGAAACGGCGTGGGACAGTAAAAAAATTACCGATACGTTGAAAGCGTTGCCGACCTACGG
ACCGCTGCTTCCCGCCGTGGTCACCAGCGCTAATCCGCAAGAGGCGACCGCTGCGCTTGCCGACGGTACGTCCGTTTCGC
TACATATGGAAGGAATGCGTTGGGCGCGGCCTTACCGCTCGGATACACAGCAGGGGCCGACGCCGCGTAAAGTTACCGAT
GTCGTCCAGACAGGTCAGCAAATCTGGGTTCGTCAGGTGGATAACGACTGGTGGCTGGCGCAGGTACCGGAAGTGAACTC
CGCGCTGGTTTCGCTTAACCCGCAAACTGGCGCGGTACTGGCGCTGGTCGGCGGTTTCGATTTTAATCAGAGTAAATTTA
ACCGCGCGACGCAAGCTTTGCGTCAGGTGGGGTCGAACATCAAACCGTTCCTCTACACCGCCGCAATGGATAAAGGCCTG
ACGCTCGCCAGTATGCTCAACGATGTGCCGATTTCCCGCTGGGACGCCGGGGCCGGTTCAGACTGGCGTCCGAAAAACTC
TCCGCCGCAGTACGCCGGACCGATTCGTTTACGCCAGGGGCTGGGGCAGTCGAAAAACGTGGTGATGGTACGCGCCATGC
GCGCCATGGGCGTCGACTATGCGGCGGAGTATCTGCAACGCTTCGGCTTCCCGGCGCAGAATATCGTGCATACCGAATCG
CTGGCGCTGGGCTCCGCCTCCTTCACGCCGATGCAGGTTGCGCGCGGTTATGCGGTGATGGCGAACGGCGGTTTCCTGAT
CGACCCGTATTTCATCAGCAAGATTGAGAACGATCAGGGCGGCGTGATCTTCGAAGCGAAACCGAAAATCGCCTGCACGG
AGTGCGATATCCCGGTCATTTACGGCAATACGCAGAAATCCGACGTGCTGGAAAACACCAATGTGGAAGAGGTCGCGGTT
TCGCAAGAGCAGCAAAACAGCGCCGTACCGATGCCTGAGCTGGAACAGGCAAACCAGGCGCTGGTCGCGCAAAACGGCAC
GCAGGAGTACGCGCCGCATGTGATCAATACGCCGCTGGCGTTTCTGATCAAAAGCGCGCTGAACACCAATATCTTCGGCG
AACCCGGCTGGATGGGTACCGGCTGGCGTGCGGCGCGCGACCTTAAACGTCGCGATATCGGCGGCAAAACCGGTACGACC
AACAGCTCGAAAGACGCATGGTTCTCCGGCTATGGTCCTGGCGTCGTCACTTCCGTATGGATCGGCTTTGACGATCACCG
CCGTGATTTAGGCCGCACCACCGCTTCCGGCGCGATCAAAGATCAAATCTCCGGCTATGAGGGCGGCGCGAAGAGCGCGC
AACCTGCATGGGACGCCTATATGAAAGCCGTGCTGGAAGGCGTGCCGGAACAGCCGCTAACGCCGCCGCCGGGCATCGTC
ACGGTGAATATCGACCGCAGTACCGGACAACTGGCGAGCGGCGGTAACAGCCGTGAAGAGTATTTCATCGAAGGCACGCA
GCCGACACAACAGGCGGTACACGAGGTGGGAACCACCATTATTGATAATGGTGAAACACACGAACTGTTCTGA

Upstream 100 bases:

>100_bases
CCCGTCGCGTTAACGGGTATATCAATGCGTCTGGCTTGCCTTTATACTACCGCGCGTTTGTTTATAAACTGCCCAAATGA
CACTAAATGGGAAATCTCCA

Downstream 100 bases:

>100_bases
TCAAAAAAGGCGCTCCGGCGCCTTTTTTATTGTGTTTAGCGGATGACGGCGAACGGGGAGACAAACTTTCCGTTGGCTTG
ATCAACGCCGCGCCATCAGG

Product: peptidoglycan synthetase

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 850; Mature: 850

Protein sequence:

>850_residues
MKFVKYLLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQIPPEMIN
AFIATEDSRFYEHHGIDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLNKNEIL
ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLSLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLSEGYITQAQY
DQARSEPIDANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYSGPA
NVLWKVGETAWDSKKITDTLKALPTYGPLLPAVVTSANPQEATAALADGTSVSLHMEGMRWARPYRSDTQQGPTPRKVTD
VVQTGQQIWVRQVDNDWWLAQVPEVNSALVSLNPQTGAVLALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL
TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES
LALGSASFTPMQVARGYAVMANGGFLIDPYFISKIENDQGGVIFEAKPKIACTECDIPVIYGNTQKSDVLENTNVEEVAV
SQEQQNSAVPMPELEQANQALVAQNGTQEYAPHVINTPLAFLIKSALNTNIFGEPGWMGTGWRAARDLKRRDIGGKTGTT
NSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV
TVNIDRSTGQLASGGNSREEYFIEGTQPTQQAVHEVGTTIIDNGETHELF

Sequences:

>Translated_850_residues
MKFVKYLLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQIPPEMIN
AFIATEDSRFYEHHGIDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLNKNEIL
ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLSLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLSEGYITQAQY
DQARSEPIDANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYSGPA
NVLWKVGETAWDSKKITDTLKALPTYGPLLPAVVTSANPQEATAALADGTSVSLHMEGMRWARPYRSDTQQGPTPRKVTD
VVQTGQQIWVRQVDNDWWLAQVPEVNSALVSLNPQTGAVLALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL
TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES
LALGSASFTPMQVARGYAVMANGGFLIDPYFISKIENDQGGVIFEAKPKIACTECDIPVIYGNTQKSDVLENTNVEEVAV
SQEQQNSAVPMPELEQANQALVAQNGTQEYAPHVINTPLAFLIKSALNTNIFGEPGWMGTGWRAARDLKRRDIGGKTGTT
NSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV
TVNIDRSTGQLASGGNSREEYFIEGTQPTQQAVHEVGTTIIDNGETHELF
>Mature_850_residues
MKFVKYLLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQIPPEMIN
AFIATEDSRFYEHHGIDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLNKNEIL
ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLSLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLSEGYITQAQY
DQARSEPIDANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYSGPA
NVLWKVGETAWDSKKITDTLKALPTYGPLLPAVVTSANPQEATAALADGTSVSLHMEGMRWARPYRSDTQQGPTPRKVTD
VVQTGQQIWVRQVDNDWWLAQVPEVNSALVSLNPQTGAVLALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL
TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES
LALGSASFTPMQVARGYAVMANGGFLIDPYFISKIENDQGGVIFEAKPKIACTECDIPVIYGNTQKSDVLENTNVEEVAV
SQEQQNSAVPMPELEQANQALVAQNGTQEYAPHVINTPLAFLIKSALNTNIFGEPGWMGTGWRAARDLKRRDIGGKTGTT
NSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV
TVNIDRSTGQLASGGNSREEYFIEGTQPTQQAVHEVGTTIIDNGETHELF

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=850, Percent_Identity=92.5882352941177, Blast_Score=1649, Evalue=0.0,
Organism=Escherichia coli, GI1786343, Length=251, Percent_Identity=35.8565737051793, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1788867, Length=261, Percent_Identity=35.632183908046, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI1789601, Length=176, Percent_Identity=38.0681818181818, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 93545; Mature: 93545

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVKYLLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH
YGEKRRIPVTLDQIPPEMINAFIATEDSRFYEHHGIDPVGIFRAASVALFSGHASQGAST
CCCCCCCCEEHHHCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHH
ITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLNKNEILELYLNKIYLGYRAYGVGAAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCHH
QVYFGKTVDQLSLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLSEGYITQAQY
HEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DQARSEPIDANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQ
HHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHCCCEEHHHHHHHHHHHHH
QAVRNNVLDYDMRHGYSGPANVLWKVGETAWDSKKITDTLKALPTYGPLLPAVVTSANPQ
HHHHCCCCCHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCH
EATAALADGTSVSLHMEGMRWARPYRSDTQQGPTPRKVTDVVQTGQQIWVRQVDNDWWLA
HHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHEECCCCEEEE
QVPEVNSALVSLNPQTGAVLALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL
ECCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC
TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH
AAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANGGFLIDPYFISKIENDQG
HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCEEEEECCCEEECHHHHHHCCCCCC
GVIFEAKPKIACTECDIPVIYGNTQKSDVLENTNVEEVAVSQEQQNSAVPMPELEQANQA
CEEEECCCCEEEEECCEEEEECCCCHHHHHCCCCHHHHHHCHHHCCCCCCCCCHHHHCHH
LVAQNGTQEYAPHVINTPLAFLIKSALNTNIFGEPGWMGTGWRAARDLKRRDIGGKTGTT
HHHCCCCHHHCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
NSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDAY
CCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCHHHCCHHHHHHCCCCCCCCCCCHHHHHH
MKAVLEGVPEQPLTPPPGIVTVNIDRSTGQLASGGNSREEYFIEGTQPTQQAVHEVGTTI
HHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCEE
IDNGETHELF
ECCCCCCCCC
>Mature Secondary Structure
MKFVKYLLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH
YGEKRRIPVTLDQIPPEMINAFIATEDSRFYEHHGIDPVGIFRAASVALFSGHASQGAST
CCCCCCCCEEHHHCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHH
ITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLNKNEILELYLNKIYLGYRAYGVGAAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCHH
QVYFGKTVDQLSLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLSEGYITQAQY
HEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DQARSEPIDANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQ
HHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHCCCEEHHHHHHHHHHHHH
QAVRNNVLDYDMRHGYSGPANVLWKVGETAWDSKKITDTLKALPTYGPLLPAVVTSANPQ
HHHHCCCCCHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCH
EATAALADGTSVSLHMEGMRWARPYRSDTQQGPTPRKVTDVVQTGQQIWVRQVDNDWWLA
HHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHEECCCCEEEE
QVPEVNSALVSLNPQTGAVLALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL
ECCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC
TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH
AAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANGGFLIDPYFISKIENDQG
HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCEEEEECCCEEECHHHHHHCCCCCC
GVIFEAKPKIACTECDIPVIYGNTQKSDVLENTNVEEVAVSQEQQNSAVPMPELEQANQA
CEEEECCCCEEEEECCEEEEECCCCHHHHHCCCCHHHHHHCHHHCCCCCCCCCHHHHCHH
LVAQNGTQEYAPHVINTPLAFLIKSALNTNIFGEPGWMGTGWRAARDLKRRDIGGKTGTT
HHHCCCCHHHCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
NSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDAY
CCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCHHHCCHHHHHHCCCCCCCCCCCHHHHHH
MKAVLEGVPEQPLTPPPGIVTVNIDRSTGQLASGGNSREEYFIEGTQPTQQAVHEVGTTI
HHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCEE
IDNGETHELF
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3882429; 9278503; 3920658; 7006606; 9841666 [H]