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The map label for this gene is adh [H]

Identifier: 227826925

GI number: 227826925

Start: 514093

End: 515172

Strand: Direct

Name: adh [H]

Synonym: M1425_0567

Alternate gene names: 227826925

Gene position: 514093-515172 (Clockwise)

Preceding gene: 227826923

Following gene: 227826926

Centisome position: 19.71

GC content: 40.37

Gene sequence:

>1080_bases
ATGTTTGGAATCACCTTTTATTCGGCGATGAGGAAAAACATAAGTATGGTTAAATCAAAAGCAGCCCTTCTGAAGAAGTT
CTCAGAACCATTATCGATAGAAGACGTTGAAATTCCTGAACCAAAGGGGGAAGAGGTTTTAGTAAGAATAGGAGGAGCTG
GAGTCTGCAGAACCGATTTGAGAGTATGGAAAGGAGTTGAAGCGAAACAAGGTTTCAGATTACCAATAATATTGGGCCAT
GAAAATGCCGGGACAGTAGTAGAAGTTGGGGAATTGGCAAAGGCAAAGAAGGGAGATAACGTTGTGGTTTACGCAACCTG
GGGTGACATGACTTGCAGATATTGCAGAGAGGGGAAGTTTAACATTTGCAAAAATCAAGTGATCCCTGGGCAAACAACAA
ATGGCGGTTTCTCAGAGTACATGTTAGTTAAAAGCTATAGATGGTTAGTGAAATTAGACAGCCTAAGCCCAGTTGATGCA
TCACCATTAGCAGATGCTGGTACTACTTCTATGGGAGCTATAAGGCAAGCCTTACCGTTTATGAACAAATTCGCAGAACC
AGTTGTGATAGTTAACGGTATTGGAGGGTTAGCCGTTTACACCATCCAAATATTAAAGGCGCTAATGAAGAATATAGTTA
TAGTTGGAATTTCTAGGAGTAAAAAGCATAGGGATTTGGCGTTAGAGTTGGGAGCGGATTACGCGGTTGAAATGAAAGAA
GCTGAAAGTTTAATAAGCAAACTCACAGATGGCTTAGGTGCCAGTGTTGCAATAGATTTAGTGGGAACAGAGGAAACTTC
TTATAATTTAGGAAAGTTGTTAGCACAAGAGGGTGCAATAATACTAGTGGGTATGGAGGGGAAGAGGGTTAGTTTAGAGG
CCTTTGATACTGCGGTATGGAATAAGAAGCTTCTGGGTTCCAATTACGGTTCACTAAACGATTTAGAAGACGTTGTAAGA
CTTAGCGAAAGTGGGAAAATTAAGCCATATGTTGTTAAAATACCTTTAGATGAAATAAACAAGGCCTTTAAGGATTTAGA
TGAGGGAAGAGTAGAGGGAAGACAAGTAATAACACCTTAG

Upstream 100 bases:

>100_bases
ATCTATTAACCCTAACTTGTGGGGATAAGAATGATAGTCTCATACAGAATATACTCAACTAATCTTAACATCTATCTAAA
AATTAGTACCAAACCCTAAC

Downstream 100 bases:

>100_bases
CTCAAGTTAAGGCTTAAATGGTAACTTTTATCTCATTGGATGAAACTATCCTAAACCACGTTATTAGCCTTTTCAATAAT
ATTACTCCAAGCTTTAACTT

Product: alcohol dehydrogenase GroES domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MFGITFYSAMRKNISMVKSKAALLKKFSEPLSIEDVEIPEPKGEEVLVRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGH
ENAGTVVEVGELAKAKKGDNVVVYATWGDMTCRYCREGKFNICKNQVIPGQTTNGGFSEYMLVKSYRWLVKLDSLSPVDA
SPLADAGTTSMGAIRQALPFMNKFAEPVVIVNGIGGLAVYTIQILKALMKNIVIVGISRSKKHRDLALELGADYAVEMKE
AESLISKLTDGLGASVAIDLVGTEETSYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVR
LSESGKIKPYVVKIPLDEINKAFKDLDEGRVEGRQVITP

Sequences:

>Translated_359_residues
MFGITFYSAMRKNISMVKSKAALLKKFSEPLSIEDVEIPEPKGEEVLVRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGH
ENAGTVVEVGELAKAKKGDNVVVYATWGDMTCRYCREGKFNICKNQVIPGQTTNGGFSEYMLVKSYRWLVKLDSLSPVDA
SPLADAGTTSMGAIRQALPFMNKFAEPVVIVNGIGGLAVYTIQILKALMKNIVIVGISRSKKHRDLALELGADYAVEMKE
AESLISKLTDGLGASVAIDLVGTEETSYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVR
LSESGKIKPYVVKIPLDEINKAFKDLDEGRVEGRQVITP
>Mature_359_residues
MFGITFYSAMRKNISMVKSKAALLKKFSEPLSIEDVEIPEPKGEEVLVRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGH
ENAGTVVEVGELAKAKKGDNVVVYATWGDMTCRYCREGKFNICKNQVIPGQTTNGGFSEYMLVKSYRWLVKLDSLSPVDA
SPLADAGTTSMGAIRQALPFMNKFAEPVVIVNGIGGLAVYTIQILKALMKNIVIVGISRSKKHRDLALELGADYAVEMKE
AESLISKLTDGLGASVAIDLVGTEETSYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVR
LSESGKIKPYVVKIPLDEINKAFKDLDEGRVEGRQVITP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=28.8, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=27.5401069518717, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=381, Percent_Identity=26.246719160105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=27.6139410187668, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501929, Length=374, Percent_Identity=27.807486631016, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=26.6129032258064, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=376, Percent_Identity=25.2659574468085, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4501939, Length=375, Percent_Identity=25.3333333333333, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=25.1989389920424, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=25.1515151515152, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87081918, Length=321, Percent_Identity=26.4797507788162, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=299, Percent_Identity=29.0969899665552, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=28.5285285285285, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=22.7544910179641, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786518, Length=359, Percent_Identity=26.1838440111421, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788073, Length=281, Percent_Identity=27.7580071174377, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=28.5333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787863, Length=315, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082401, Length=352, Percent_Identity=26.1363636363636, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=24.929178470255, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=188, Percent_Identity=30.8510638297872, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=24.2811501597444, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=25.5014326647564, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=24.4956772334294, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=22.8070175438596, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=325, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=376, Percent_Identity=27.6595744680851, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=378, Percent_Identity=27.5132275132275, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17544682, Length=373, Percent_Identity=26.5415549597855, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=243, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=27.7456647398844, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=26.1627906976744, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=363, Percent_Identity=26.1707988980716, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=25.2906976744186, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=28.686327077748, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=327, Percent_Identity=24.4648318042813, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=353, Percent_Identity=25.7790368271955, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=334, Percent_Identity=23.3532934131737, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=353, Percent_Identity=25.7790368271955, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=28.5333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137530, Length=247, Percent_Identity=23.8866396761134, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39076; Mature: 39076

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGITFYSAMRKNISMVKSKAALLKKFSEPLSIEDVEIPEPKGEEVLVRIGGAGVCRTDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHH
RVWKGVEAKQGFRLPIILGHENAGTVVEVGELAKAKKGDNVVVYATWGDMTCRYCREGKF
HHHCCCCCCCCCEEEEEEECCCCCCEEEHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCC
NICKNQVIPGQTTNGGFSEYMLVKSYRWLVKLDSLSPVDASPLADAGTTSMGAIRQALPF
EECCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
MNKFAEPVVIVNGIGGLAVYTIQILKALMKNIVIVGISRSKKHRDLALELGADYAVEMKE
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCEEHHHH
AESLISKLTDGLGASVAIDLVGTEETSYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVW
HHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHH
NKKLLGSNYGSLNDLEDVVRLSESGKIKPYVVKIPLDEINKAFKDLDEGRVEGRQVITP
HHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MFGITFYSAMRKNISMVKSKAALLKKFSEPLSIEDVEIPEPKGEEVLVRIGGAGVCRTDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHH
RVWKGVEAKQGFRLPIILGHENAGTVVEVGELAKAKKGDNVVVYATWGDMTCRYCREGKF
HHHCCCCCCCCCEEEEEEECCCCCCEEEHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCC
NICKNQVIPGQTTNGGFSEYMLVKSYRWLVKLDSLSPVDASPLADAGTTSMGAIRQALPF
EECCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
MNKFAEPVVIVNGIGGLAVYTIQILKALMKNIVIVGISRSKKHRDLALELGADYAVEMKE
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCEEHHHH
AESLISKLTDGLGASVAIDLVGTEETSYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVW
HHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHH
NKKLLGSNYGSLNDLEDVVRLSESGKIKPYVVKIPLDEINKAFKDLDEGRVEGRQVITP
HHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA