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The map label for this gene is iolF [H]

Identifier: 227826923

GI number: 227826923

Start: 511451

End: 512842

Strand: Direct

Name: iolF [H]

Synonym: M1425_0565

Alternate gene names: 227826923

Gene position: 511451-512842 (Clockwise)

Preceding gene: 227826922

Following gene: 227826925

Centisome position: 19.6

GC content: 39.22

Gene sequence:

>1392_bases
ATGAGTGAACCTTCAGATCCTCTAAAAGCACTTGATGAGGCTAAACTATCATCTACGCACTATAGGTGGACAATCCTATC
TGCTTTAGCAGATTTTCTTGATGCAGGAGCGATAGTTGCGGGTGCCGCATCAGTAAGTATATGGGTTTCCCTCTTCCATC
TTAATTCCCTTCTCTTAGGTATAATAGCTGCGTTAAGTCCAAATGCCTTTGCCGCTGGTATAGGAGCTTGGATAGCTGGA
CCACTAGGTGACAGATATGGAAGGAAGGCTATATATACATATGATCTAATCGTATATGCAATAGGTGCAATAATTATATT
ATCAGCAATAAATTACTACATGGTTATTATAGGGTATACTATAGTAGGGTTGGCAGTGGGAGTTGACGTACCAACAAGTT
GGTCACTAATAGCTGAGCTAGCTCCTAAGAGGAATCGCGGAAGATTAATGTCATTCACTAACTTATTCTGGTATATTGGA
CCCATAATAATATTGCTTCTAGGTATAGGCACAGTTCCGTTGGGTGTTAATTCCTTTAGAGTCCTATTCGGGTTTTTGAC
AATAGTTGCAATAGTAACATGGGTCTTAAGAAGAGGAATTGCTGAATCCGCTAGATGGGGGCTAGTGAAGGGAAAAGAAG
AAGTGGTTAAACAAGCATTAGCGCAATTAGGACAAAGCGTAAGTGTAATACCTAAGGCTGAGACCAAAGGTAAGTGGAGT
GATATGTTCAAATATTGGAAAGGATTAGCCTTCATGATCCCAATCTATATTTTCTGGGGAGTACCAGCTGGAACCTTTGG
ATTCTTCTTACCTTTCCTCATAGAAGATTTGTCTATCAAAAGTTCTGTAGTAGGTGATCTAGTTCAAATCGCGTGGTTCG
TGACTGCAATAATTGGAGTTGTTGGAGTATACATGCAGCTATCAGACAAAGTGAATAGGAAGCTATTATATGCAGTAAGT
TCTCTTATTTGCGCAATTGGTTTCGCATTACCTATAGGTTTACCATTCAAGATACTTTGGGTAGCATTATTCAATGTATT
CTTATTTGGATTTGGTCATGGAATGGCGTTATGGCCTCAAACTAGAGTCTGGTCAACGGAGCTTTTCCCAACGGAAATAA
GAAACACGGCTCAAGGTTTTGTATGGGGCTGGATGAGGATAGCATTGGGAATATGGAGTATCTTCGTACCTTCAATAATT
ACAGTAATAGGTTATTCAGCAATAGCTGCAGTAGCTACTTCATTCTTTATACTAAATATTATTTTGGGATTATTAGTGGG
ACCGGATACACATGGAAAATCCTTAGAGGTGGTAATAAAGGACTTTTATGGAGGTAAAGTTCCAGTATCTAAAGTAGTAG
AAGTGAATACAAGACCTCTTGGCAACAAATAA

Upstream 100 bases:

>100_bases
TCTAAGCATATTATGTTTTAAAAATTTACCGGACAGAATACATATCTCCATATAAGTATGGACCCTTACTTATAAACTAT
ATATAACATAAATACCAATA

Downstream 100 bases:

>100_bases
ACTATTAAAGGTCATACTTTAAGCCAAAACCTTTTTCTTCTCCCAATTCGAAATATCCCTTTATTGGCTTAGGAGGATTT
ATCACTCTATCCTCTAGCCA

Product: major facilitator superfamily MFS_1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSEPSDPLKALDEAKLSSTHYRWTILSALADFLDAGAIVAGAASVSIWVSLFHLNSLLLGIIAALSPNAFAAGIGAWIAG
PLGDRYGRKAIYTYDLIVYAIGAIIILSAINYYMVIIGYTIVGLAVGVDVPTSWSLIAELAPKRNRGRLMSFTNLFWYIG
PIIILLLGIGTVPLGVNSFRVLFGFLTIVAIVTWVLRRGIAESARWGLVKGKEEVVKQALAQLGQSVSVIPKAETKGKWS
DMFKYWKGLAFMIPIYIFWGVPAGTFGFFLPFLIEDLSIKSSVVGDLVQIAWFVTAIIGVVGVYMQLSDKVNRKLLYAVS
SLICAIGFALPIGLPFKILWVALFNVFLFGFGHGMALWPQTRVWSTELFPTEIRNTAQGFVWGWMRIALGIWSIFVPSII
TVIGYSAIAAVATSFFILNIILGLLVGPDTHGKSLEVVIKDFYGGKVPVSKVVEVNTRPLGNK

Sequences:

>Translated_463_residues
MSEPSDPLKALDEAKLSSTHYRWTILSALADFLDAGAIVAGAASVSIWVSLFHLNSLLLGIIAALSPNAFAAGIGAWIAG
PLGDRYGRKAIYTYDLIVYAIGAIIILSAINYYMVIIGYTIVGLAVGVDVPTSWSLIAELAPKRNRGRLMSFTNLFWYIG
PIIILLLGIGTVPLGVNSFRVLFGFLTIVAIVTWVLRRGIAESARWGLVKGKEEVVKQALAQLGQSVSVIPKAETKGKWS
DMFKYWKGLAFMIPIYIFWGVPAGTFGFFLPFLIEDLSIKSSVVGDLVQIAWFVTAIIGVVGVYMQLSDKVNRKLLYAVS
SLICAIGFALPIGLPFKILWVALFNVFLFGFGHGMALWPQTRVWSTELFPTEIRNTAQGFVWGWMRIALGIWSIFVPSII
TVIGYSAIAAVATSFFILNIILGLLVGPDTHGKSLEVVIKDFYGGKVPVSKVVEVNTRPLGNK
>Mature_462_residues
SEPSDPLKALDEAKLSSTHYRWTILSALADFLDAGAIVAGAASVSIWVSLFHLNSLLLGIIAALSPNAFAAGIGAWIAGP
LGDRYGRKAIYTYDLIVYAIGAIIILSAINYYMVIIGYTIVGLAVGVDVPTSWSLIAELAPKRNRGRLMSFTNLFWYIGP
IIILLLGIGTVPLGVNSFRVLFGFLTIVAIVTWVLRRGIAESARWGLVKGKEEVVKQALAQLGQSVSVIPKAETKGKWSD
MFKYWKGLAFMIPIYIFWGVPAGTFGFFLPFLIEDLSIKSSVVGDLVQIAWFVTAIIGVVGVYMQLSDKVNRKLLYAVSS
LICAIGFALPIGLPFKILWVALFNVFLFGFGHGMALWPQTRVWSTELFPTEIRNTAQGFVWGWMRIALGIWSIFVPSIIT
VIGYSAIAAVATSFFILNIILGLLVGPDTHGKSLEVVIKDFYGGKVPVSKVVEVNTRPLGNK

Specific function: Minor myo-inositol uptake transporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786229, Length=442, Percent_Identity=22.8506787330317, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87082159, Length=452, Percent_Identity=21.4601769911504, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652795, Length=418, Percent_Identity=22.9665071770335, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652793, Length=418, Percent_Identity=22.9665071770335, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50475; Mature: 50344

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHEECCCCCCCC
>Mature Secondary Structure 
SEPSDPLKALDEAKLSSTHYRWTILSALADFLDAGAIVAGAASVSIWVSLFHLNSLLLG
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7952181; 9384377; 1761221; 11807058 [H]