Click here to switch to the map view.

The map label for this gene is pcp1 [H]

Identifier: 227826869

GI number: 227826869

Start: 434182

End: 434814

Strand: Direct

Name: pcp1 [H]

Synonym: M1425_0496

Alternate gene names: 227826869

Gene position: 434182-434814 (Clockwise)

Preceding gene: 227826868

Following gene: 227826871

Centisome position: 16.64

GC content: 38.55

Gene sequence:

>633_bases
GTGGTCAGAGTCCTCTTGTTTGGCTTCGAACCCTTTTTGGAATACAAGGAAAATCCATCTCAGTTAATTGTTGAAGCCTT
AAATGGAAGTACCATATTAAAGGAAGAGGTCAAAGGTGTGATATTGCCAGTTGAGTATGAGAAGATAGAGGATTTAATAG
TTACGAAAATTAGAGAGATGAAACCAATATTAACTTTAGGAATTGGTGTAGCCCCAGGTAGGGCGAAGATAACTCCAGAG
AAGATAGCCATAAACTACAAGTACTCAAGGGAAGGAGATAACGCTGGGAAGAAGTACAAGGGAGAGAAGATTGACCCCTT
AGGGCAAGACGGTATCTTTACGAATATACCAGTTGAGGACCTCGTAGACTTATTGAATGAAAACGGAATACCAGCTGAAT
TGAGCTTAAGTGCTGGTAGTTATCTGTGTAATAACGCAATGTACATCATAATTAGGGAAGCTAGAAAGTACAATAGCTTA
GGTGGTTTCATTCACGTTCCCTTACACGAGTCATATGCCGCGAGAATACAACGACCTATTCCATCTATGAGTTTAGATAC
TATGATAAGGGGAATAAGGTTATCAATGGAATTTATATTAACAAATAAAAAAGAGAATCTTACCTTCTCCTAG

Upstream 100 bases:

>100_bases
GGTGGGTAATTCCCACCAGCTATGAAGTGATGAGGATGAAGGCGGTAAACCACAAACCCATGATTCGCCCTGAGGGAACC
CTCGCCCTTCAGGCGGGGAG

Downstream 100 bases:

>100_bases
TTGTCGTTGTAAACAGTTTACAGTAAATTGTGAAGTTTGTGTTATTTTTGACTATTGAAAGACCCTTATGAAGGTTTTGA
AAAGTCTAGATCATTTTATT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 1; Pyroglutamyl-peptidase I 1; PGP-I 1; Pyrase 1 [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MVRVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREMKPILTLGIGVAPGRAKITPE
KIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSL
GGFIHVPLHESYAARIQRPIPSMSLDTMIRGIRLSMEFILTNKKENLTFS

Sequences:

>Translated_210_residues
MVRVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREMKPILTLGIGVAPGRAKITPE
KIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSL
GGFIHVPLHESYAARIQRPIPSMSLDTMIRGIRLSMEFILTNKKENLTFS
>Mature_210_residues
MVRVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREMKPILTLGIGVAPGRAKITPE
KIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSL
GGFIHVPLHESYAARIQRPIPSMSLDTMIRGIRLSMEFILTNKKENLTFS

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23559; Mature: 23559

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREM
CEEEEEECCCHHHHCCCCHHHHHHHHHCCCEEEHHHHCEEEEEECHHHHHHHHHHHHHHH
KPILTLGIGVAPGRAKITPEKIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVED
CCEEEEECCCCCCCCEECHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCHHH
LVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRPI
HHHHHCCCCCCEEEEECCCCEECCCEEEEEEEECHHCCCCCCEEEECCCHHHHHHHHCCC
PSMSLDTMIRGIRLSMEFILTNKKENLTFS
CCCCHHHHHHHHHEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MVRVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREM
CEEEEEECCCHHHHCCCCHHHHHHHHHCCCEEEHHHHCEEEEEECHHHHHHHHHHHHHHH
KPILTLGIGVAPGRAKITPEKIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVED
CCEEEEECCCCCCCCEECHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCHHH
LVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRPI
HHHHHCCCCCCEEEEECCCCEECCCEEEEEEEECHHCCCCCCEEEECCCHHHHHHHHCCC
PSMSLDTMIRGIRLSMEFILTNKKENLTFS
CCCCHHHHHHHHHEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]