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The map label for this gene is yclK [H]

Identifier: 227815204

GI number: 227815204

Start: 2377714

End: 2379093

Strand: Reverse

Name: yclK [H]

Synonym: BAMEG_2615

Alternate gene names: 227815204

Gene position: 2379093-2377714 (Counterclockwise)

Preceding gene: 227815205

Following gene: 227815203

Centisome position: 45.49

GC content: 31.88

Gene sequence:

>1380_bases
GTGGAAGGAAAGTATAAGATGAAAAGAAAAGTGACTTTATATTTTATGACGGTCATTATACTTATGCTTGTATTATTTGA
AGTCGTATTTTCAGTCTCCGTTTACCGATATTATTATAATGGTATTGTGCAATATGTAGAATCTCATGCGAAGACAAGTA
CACGATTTTTCTCTGAATACAATTCATTATACTTTATTCGTTTGCAAGAATATAGCGGGGATATAATTGAGAGTTTTCAG
TTAGAAGGAACCGAATTACAATTAATTGATCGACATGGTACGATTATACAATCGTCAAGTGGAGAAAAGACAGAGGGTAA
AGTAGTTATTCCGTATTCGTTACTAGAAGGAGAAATGTACCACCAAGTGACTACTACGAAGGACAAAGTGAAACAATTAG
AAGTGATTAGTCCGCTGATTCATCAAGGACAAACGATTGGTGTTTTAAAATATACGACTGTATTAACACATGTAAATGCC
AAGATTATTGAAATTATTATGTTTACGATTTGTGTAGGTATTGTTATTTCAGGAATTGTATTCTTAATTAGTAGACGATT
AGCGAATTCATTTGTTAAACCAATCGAATCTATAATTCATGCTTCTTCTCAAATTGCAGAAGGTACATTAAAGAAGAAAA
TTAAAGAAGATTATCCTGGTGAATTAGGTGAGTTAGCACATAGTTTAAATCATATGTCTGATAAAATAGAAAAAGCGGAA
CAGATGAAAAATGAATTTATTGCTTCTATTTCTCATGAAATACGAACCCCTTTAACTGGAATTAAGGGTTGGAGTGAAAC
GTTAAAAACGGTAGATCATTTAACGGAAGAAGAAATAAAGCAAGGCATGGGGATTATTTCAGGTGAGACAGACAGATTAA
TTCATTTAGTAGAAGAATTGCTAGATTTTTCAAGGTTGCAATCAAATCATTTTAATTTATATAAACAAAAGGTGCAATTA
TACGATATACTAGAGGAGACGATTTGGCAATTAACTCCTAATGCTGAAGAGAAGAAAATGCAATTCATCAAAACTATAGA
ACGAATTGAATTGATAGGAGATCGAAATAGGCTAAAGCAAATTTTCTTGAATATTGTTCAAAATGCCATTAAATATTCAC
ATGAAAATGGTAAAGTATATATTGAAGCGACTAAAAATGAAGGACAAGCAGTCATAAAGGTGAAAGACGATGGGATTGGA
ATTGCTAAAGAGCATTTACCGTATATAGAACAGTCATTTTACCAGATTAATAATCATGCTACAGGTGCTGGTCTTGGTTT
AGCTATCGTTAAAAAAATGGTGGAGCTTCATGGAGGTACAATAAATATTATAAGTAAAGAAGGAATAGGAACGACCATTT
TGATAAAACTCCCATTATAA

Upstream 100 bases:

>100_bases
CGAAAGTAGTAGATGTAAATATGAGGCGGTTACGTCAAAAGATAGAGTGTAATCCATCAGAACCTGAATTTATTCTTACT
GTGTGGGGAAAAGGATATGT

Downstream 100 bases:

>100_bases
TACATATAAAGTCTGTTTATATAGTGTAATAAAATAAATAGATGTATAATTATATTGGGTGATTTATATATAAGATTAAT
AGGGAGAGGAATTCGATAGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHAKTSTRFFSEYNSLYFIRLQEYSGDIIESFQ
LEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNA
KIIEIIMFTICVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDKIEKAE
QMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLYKQKVQL
YDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHENGKVYIEATKNEGQAVIKVKDDGIG
IAKEHLPYIEQSFYQINNHATGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL

Sequences:

>Translated_459_residues
MEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHAKTSTRFFSEYNSLYFIRLQEYSGDIIESFQ
LEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNA
KIIEIIMFTICVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDKIEKAE
QMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLYKQKVQL
YDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHENGKVYIEATKNEGQAVIKVKDDGIG
IAKEHLPYIEQSFYQINNHATGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
>Mature_459_residues
MEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHAKTSTRFFSEYNSLYFIRLQEYSGDIIESFQ
LEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNA
KIIEIIMFTICVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDKIEKAE
QMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLYKQKVQL
YDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHENGKVYIEATKNEGQAVIKVKDDGIG
IAKEHLPYIEQSFYQINNHATGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=28.6231884057971, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789149, Length=342, Percent_Identity=29.2397660818713, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.5303643724696, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=26.5232974910394, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=31.4655172413793, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=431, Percent_Identity=24.5939675174014, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=30.4721030042918, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=29.8701298701299, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.695652173913, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789808, Length=322, Percent_Identity=25.4658385093168, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=348, Percent_Identity=26.1494252873563, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=29.5652173913043, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=29.3172690763052, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=24.8299319727891, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=27.7372262773723, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789403, Length=291, Percent_Identity=27.8350515463918, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=22.2950819672131, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790861, Length=327, Percent_Identity=25.0764525993884, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52260; Mature: 52260

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHAKTSTRFFSEY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSLYFIRLQEYSGDIIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMY
CCEEEEEEECCCCCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHHHCCHHH
HQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNAKIIEIIMFTICVGIVISGIV
HHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDKIEKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
QMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEEL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
LDFSRLQSNHFNLYKQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
IFLNIVQNAIKYSHENGKVYIEATKNEGQAVIKVKDDGIGIAKEHLPYIEQSFYQINNHA
HHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHCCCC
TGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHAKTSTRFFSEY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSLYFIRLQEYSGDIIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMY
CCEEEEEEECCCCCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHHHCCHHH
HQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNAKIIEIIMFTICVGIVISGIV
HHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDKIEKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
QMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEEL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
LDFSRLQSNHFNLYKQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
IFLNIVQNAIKYSHENGKVYIEATKNEGQAVIKVKDDGIGIAKEHLPYIEQSFYQINNHA
HHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHCCCC
TGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]