Definition Vibrio cholerae M66-2 chromosome I, complete genome.
Accession NC_012578
Length 2,892,523

Click here to switch to the map view.

The map label for this gene is appF [H]

Identifier: 227080797

GI number: 227080797

Start: 608894

End: 609889

Strand: Reverse

Name: appF [H]

Synonym: VCM66_0574

Alternate gene names: 227080797

Gene position: 609889-608894 (Counterclockwise)

Preceding gene: 227080798

Following gene: 227080796

Centisome position: 21.09

GC content: 49.3

Gene sequence:

>996_bases
ATGAGCAAACCACATGGCGAATTACTGGTTGAGGGAAAAAATCTGGTTAAAGATTTTGCCATCAACAGTAACGCACTCAA
ACAACCCATGATGCGTGCCATCAACGACGTATCATTCAAAATGTACAAAAGTCGCGGTTTATCTGTGGTGGGTGAGTCTG
GCTCAGGCAAATCCACCACCGCCAAGATGATCGCCAAAATGTACGCGCCGACCTCTGGGGTTATCGAGTACAAAGGCCGT
GATATTCAGGACATCGTTTCTCGTGACGACCTGATGCATTACCGCGAAGGCGTACAGATGGTATGGCAAGATCCGTTTGG
CTCACTCAACCCGACCCATACCATTTTCCACCACATTGCTCGCCCGCTGCTGATCCACAAAAAGGTTACGCCGGGCAACA
AAAAAGAGTTGGAAGAGCGTGTTTACGAACTGCTTGAACAAGTCGGCCTCATCCCACCAAAAGCTACGGCCGCGAAATAT
CCGCACCAACTTTCTGGTGGTCAGCGTCAGCGCGTTAACTTAGCACGTAACATTGCTGTTGGTGCTGAGGTTGTTCTGGC
TGATGAACCCACTTCAATGCTCGATGTGTCAATCCGTGCAGGCGTACTCAACCTGATGGAAGAGATGAAGTTTGAGCGTC
AAATGTCTCTGCTATACATCACGCACGACATCGCGACCGCTCGCTACATCGCTGAAGATTTAGCCGTTATGTACGTAGGA
CACATGGTGGAATGGGGTGATACCGATGAGATCATTCACGATCCACAGCACCCTTACACCAAGCTGTTAGTCTCTGCGGT
ACCTGATCCGAAAAAGTCGATCCACGAAAAATTGGAAGGCAACAAAGGCGAGATCCCACTGTGGACTCCGAATTCTGTCG
GCTGCCCATTTGCAGGACGCTGTTTGTACGCTTCCGCGAAATGTCGCGAAGCCTTGCCAGAAGTCACTCAGTTGTCTGAC
AACCACTTTGTTCGTTGTTATCTGTTTGAAAAATAA

Upstream 100 bases:

>100_bases
TGGCCGCTTTTCTAACTGCCATCTCTATACGCAATCGAACGCCACTATAAAACGCTAAGGCGTACGACAAAGCAGTAGCA
AAGAATTTCTGGAGACAATT

Downstream 100 bases:

>100_bases
AACCAGCAGCTCCCTCTCGTAGGGAGCTTGCTCAATCCATACTGCGGAGAAAATGAATGCTGTTACTGACCAACCACATT
GGCTATGAAACCCAAGGCCC

Product: peptide ABC transporter, ATP-binding protein

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSKPHGELLVEGKNLVKDFAINSNALKQPMMRAINDVSFKMYKSRGLSVVGESGSGKSTTAKMIAKMYAPTSGVIEYKGR
DIQDIVSRDDLMHYREGVQMVWQDPFGSLNPTHTIFHHIARPLLIHKKVTPGNKKELEERVYELLEQVGLIPPKATAAKY
PHQLSGGQRQRVNLARNIAVGAEVVLADEPTSMLDVSIRAGVLNLMEEMKFERQMSLLYITHDIATARYIAEDLAVMYVG
HMVEWGDTDEIIHDPQHPYTKLLVSAVPDPKKSIHEKLEGNKGEIPLWTPNSVGCPFAGRCLYASAKCREALPEVTQLSD
NHFVRCYLFEK

Sequences:

>Translated_331_residues
MSKPHGELLVEGKNLVKDFAINSNALKQPMMRAINDVSFKMYKSRGLSVVGESGSGKSTTAKMIAKMYAPTSGVIEYKGR
DIQDIVSRDDLMHYREGVQMVWQDPFGSLNPTHTIFHHIARPLLIHKKVTPGNKKELEERVYELLEQVGLIPPKATAAKY
PHQLSGGQRQRVNLARNIAVGAEVVLADEPTSMLDVSIRAGVLNLMEEMKFERQMSLLYITHDIATARYIAEDLAVMYVG
HMVEWGDTDEIIHDPQHPYTKLLVSAVPDPKKSIHEKLEGNKGEIPLWTPNSVGCPFAGRCLYASAKCREALPEVTQLSD
NHFVRCYLFEK
>Mature_330_residues
SKPHGELLVEGKNLVKDFAINSNALKQPMMRAINDVSFKMYKSRGLSVVGESGSGKSTTAKMIAKMYAPTSGVIEYKGRD
IQDIVSRDDLMHYREGVQMVWQDPFGSLNPTHTIFHHIARPLLIHKKVTPGNKKELEERVYELLEQVGLIPPKATAAKYP
HQLSGGQRQRVNLARNIAVGAEVVLADEPTSMLDVSIRAGVLNLMEEMKFERQMSLLYITHDIATARYIAEDLAVMYVGH
MVEWGDTDEIIHDPQHPYTKLLVSAVPDPKKSIHEKLEGNKGEIPLWTPNSVGCPFAGRCLYASAKCREALPEVTQLSDN
HFVRCYLFEK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG4608

COG function: function code E; ABC-type oligopeptide transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42490749, Length=242, Percent_Identity=28.099173553719, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI116734710, Length=213, Percent_Identity=24.8826291079812, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI105990541, Length=234, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI9961252, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI9961250, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4505771, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI255708477, Length=318, Percent_Identity=23.2704402515723, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21536376, Length=247, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21536378, Length=243, Percent_Identity=24.2798353909465, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI156105685, Length=268, Percent_Identity=25.7462686567164, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI9955963, Length=167, Percent_Identity=29.3413173652695, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI148612844, Length=242, Percent_Identity=24.3801652892562, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI150417984, Length=215, Percent_Identity=23.7209302325581, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1787500, Length=299, Percent_Identity=39.1304347826087, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1789962, Length=328, Percent_Identity=35.0609756097561, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI145693107, Length=265, Percent_Identity=41.1320754716981, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789963, Length=301, Percent_Identity=36.2126245847176, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787758, Length=318, Percent_Identity=33.6477987421384, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI48994883, Length=300, Percent_Identity=32.3333333333333, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1787759, Length=301, Percent_Identity=33.2225913621262, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1787547, Length=266, Percent_Identity=32.7067669172932, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1788506, Length=254, Percent_Identity=35.8267716535433, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI48994997, Length=236, Percent_Identity=34.3220338983051, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787548, Length=331, Percent_Identity=27.7945619335347, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789891, Length=211, Percent_Identity=32.2274881516588, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789032, Length=235, Percent_Identity=31.063829787234, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786398, Length=236, Percent_Identity=31.7796610169492, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789890, Length=241, Percent_Identity=32.7800829875519, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1788225, Length=257, Percent_Identity=31.5175097276265, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081791, Length=263, Percent_Identity=31.9391634980989, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788761, Length=224, Percent_Identity=31.6964285714286, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787029, Length=248, Percent_Identity=32.6612903225806, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87081834, Length=201, Percent_Identity=32.8358208955224, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786872, Length=237, Percent_Identity=33.7552742616034, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789873, Length=212, Percent_Identity=33.4905660377358, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788450, Length=230, Percent_Identity=30, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081709, Length=249, Percent_Identity=28.1124497991968, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789672, Length=236, Percent_Identity=30.0847457627119, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787089, Length=228, Percent_Identity=31.140350877193, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790162, Length=236, Percent_Identity=28.8135593220339, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787370, Length=233, Percent_Identity=29.1845493562232, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787712, Length=257, Percent_Identity=28.7937743190661, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786253, Length=218, Percent_Identity=29.8165137614679, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788644, Length=211, Percent_Identity=29.3838862559242, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786698, Length=194, Percent_Identity=29.3814432989691, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787105, Length=192, Percent_Identity=30.7291666666667, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790467, Length=279, Percent_Identity=25.089605734767, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082267, Length=281, Percent_Identity=28.8256227758007, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786563, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788210, Length=267, Percent_Identity=27.7153558052434, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786803, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786345, Length=234, Percent_Identity=27.3504273504274, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790739, Length=231, Percent_Identity=26.4069264069264, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786703, Length=194, Percent_Identity=29.3814432989691, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787164, Length=209, Percent_Identity=26.7942583732057, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790534, Length=230, Percent_Identity=27.8260869565217, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789586, Length=237, Percent_Identity=27.4261603375527, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788165, Length=225, Percent_Identity=23.5555555555556, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789991, Length=241, Percent_Identity=25.3112033195021, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787112, Length=228, Percent_Identity=25.4385964912281, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87081782, Length=248, Percent_Identity=24.1935483870968, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=238, Percent_Identity=28.1512605042017, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17565938, Length=243, Percent_Identity=29.2181069958848, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193209708, Length=241, Percent_Identity=29.045643153527, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646699, Length=247, Percent_Identity=27.9352226720648, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25146777, Length=266, Percent_Identity=27.4436090225564, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17543740, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115533608, Length=231, Percent_Identity=26.8398268398268, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193211015, Length=230, Percent_Identity=27.3913043478261, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI193211017, Length=230, Percent_Identity=27.3913043478261, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71996809, Length=235, Percent_Identity=27.2340425531915, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115535101, Length=230, Percent_Identity=27.8260869565217, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71992285, Length=233, Percent_Identity=26.6094420600858, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=230, Percent_Identity=24.3478260869565, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534520, Length=231, Percent_Identity=25.974025974026, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996550, Length=209, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=246, Percent_Identity=26.0162601626016, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=233, Percent_Identity=25.3218884120172, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17569143, Length=218, Percent_Identity=27.5229357798165, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324985, Length=259, Percent_Identity=25.0965250965251, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322640, Length=233, Percent_Identity=28.3261802575107, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323959, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319856, Length=239, Percent_Identity=25.9414225941423, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643674, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007184, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221500365, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 37124; Mature: 36993

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPHGELLVEGKNLVKDFAINSNALKQPMMRAINDVSFKMYKSRGLSVVGESGSGKSTT
CCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
AKMIAKMYAPTSGVIEYKGRDIQDIVSRDDLMHYREGVQMVWQDPFGSLNPTHTIFHHIA
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
RPLLIHKKVTPGNKKELEERVYELLEQVGLIPPKATAAKYPHQLSGGQRQRVNLARNIAV
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHCCCCHHHHHHHHHHHC
GAEVVLADEPTSMLDVSIRAGVLNLMEEMKFERQMSLLYITHDIATARYIAEDLAVMYVG
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHH
HMVEWGDTDEIIHDPQHPYTKLLVSAVPDPKKSIHEKLEGNKGEIPLWTPNSVGCPFAGR
HHHCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCH
CLYASAKCREALPEVTQLSDNHFVRCYLFEK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
SKPHGELLVEGKNLVKDFAINSNALKQPMMRAINDVSFKMYKSRGLSVVGESGSGKSTT
CCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
AKMIAKMYAPTSGVIEYKGRDIQDIVSRDDLMHYREGVQMVWQDPFGSLNPTHTIFHHIA
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
RPLLIHKKVTPGNKKELEERVYELLEQVGLIPPKATAAKYPHQLSGGQRQRVNLARNIAV
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHCCCCHHHHHHHHHHHC
GAEVVLADEPTSMLDVSIRAGVLNLMEEMKFERQMSLLYITHDIATARYIAEDLAVMYVG
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHH
HMVEWGDTDEIIHDPQHPYTKLLVSAVPDPKKSIHEKLEGNKGEIPLWTPNSVGCPFAGR
HHHCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCH
CLYASAKCREALPEVTQLSDNHFVRCYLFEK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]