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The map label for this gene is yjcE [H]

Identifier: 227080600

GI number: 227080600

Start: 392233

End: 393567

Strand: Reverse

Name: yjcE [H]

Synonym: VCM66_0374

Alternate gene names: 227080600

Gene position: 393567-392233 (Counterclockwise)

Preceding gene: 227080602

Following gene: 227080590

Centisome position: 13.61

GC content: 44.49

Gene sequence:

>1335_bases
ATGTCCGTCTACTACACTTTGTGCTTCCTCTCTGCGGCAGCCATGTTGATTGCATTTATTAATAGCAAGATCAGCCGAAT
GCAGACTACTATCGCAATCACCGCAGGTTCGATGATGTTATCGTTACTGATCTTGATCGCGGGTCAAAACGACTGGTTTC
ATCTCAATCAAATCGCCACCGAAACCGTCACCAGTATTAACTTTGAAAATTTTCTACTCAAAGGGATTTTAGGGTTTCTT
CTTTTCGCTGGAGGTCTTGGCATTAAGCTGCCAAATCTAAAAGATCAGAAATGGGAAATTACGGTATTGGCTCTTGGCGC
AACGCTGTTTTCGACTTTCTTTATTGGATTTACTCTCTATGGTTTCTGCCAATTAATCGGTATCCAGTTTGATTTGGTTT
ACTGCTTGTTATTTGGCGCACTCATTTCCCCCACCGACCCAATTGCTGTCCTCGCGATTGTCAAAAAGCTCAAAGCACCG
AAACGTATTTCTACCCAAATTGAAGGCGAATCACTGTTTAACGATGGTTTTGGCTTGGTTATCTTCGTGACCATCTTTAC
CATCGCTTTCGGGCATGAAACACCAACGGTTGGCAGCGTTACCCTTCTCTTCATCCAAGAAGCGATCGGTGGCATTGTTT
ACGGTTTCTTATTAGGTCTCCTGTTCCACTACCTGATTTCAGCAACCGATGACCACTCTATGGAGCTGTTGCTGACGATT
GGTATTCCGACCGCTGGTTATGCATTTGCCGATGTGATCCATGTTTCTGGTCCACTCGCTATGGTCGTATCTGGGATCAT
GATTGGTAACTGGACTCGTTTCATAGGCTTCTCAAAAGAGAGTGAAGAGCATCTCGATCACTTCTGGGAACTCGTAGACG
AATTTCTCAACGGCGTCCTATTCCTGCTGATTGGTATGTCAATGCTACTGTTTGAGTTCCATCAAGAAGACTGGATTTTA
ATGGCTTTTGCAGTTCCACTGGTGTTATGTGGCCGCTACCTCAGCGTATTTGTCTCCTACATCGGATTTAAACGCTACCG
TAGTTACAACCCTTGGTCGATTCGTATTCTGACTTGGGGTGGCTTACGTGGGGGACTCGCGTTAGCGATGGCGCTCTCTA
TACCTTCTGGAATCATGGTAATTCCCGAGAAATTGATTGATGTAAAAGAGCTGATTCTGGTGATGACTTACGCCGTGGTA
GTGTTTTCTATCCTAGTTCAAGGCTCAACCATTACTCCTATGATTGAGAAAGCTAAAAAGGCTGAAAAAGCCCTCCAAGC
TGAAAGAAATACAGACAATCAATCCCCTATGCCTCAGCAAGAACAACAACACTAA

Upstream 100 bases:

>100_bases
ACGATGTGAGCAGAACCCTATGTGATGAAAAAGTATTTGCTATTTACTCAACAGAGAAAGACAATTTCGTTCACAAATTG
TTACACACACTGAGAAGAGA

Downstream 100 bases:

>100_bases
TCTCCGTTGTTTAATCGACAAACCGCAGTTAAACACTGCGGTTTTTTATTACCCTCAGAATCCTTTCCCAGATGACTAGA
CCACTTAAACGACTTGGAGC

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSVYYTLCFLSAAAMLIAFINSKISRMQTTIAITAGSMMLSLLILIAGQNDWFHLNQIATETVTSINFENFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFTLYGFCQLIGIQFDLVYCLLFGALISPTDPIAVLAIVKKLKAP
KRISTQIEGESLFNDGFGLVIFVTIFTIAFGHETPTVGSVTLLFIQEAIGGIVYGFLLGLLFHYLISATDDHSMELLLTI
GIPTAGYAFADVIHVSGPLAMVVSGIMIGNWTRFIGFSKESEEHLDHFWELVDEFLNGVLFLLIGMSMLLFEFHQEDWIL
MAFAVPLVLCGRYLSVFVSYIGFKRYRSYNPWSIRILTWGGLRGGLALAMALSIPSGIMVIPEKLIDVKELILVMTYAVV
VFSILVQGSTITPMIEKAKKAEKALQAERNTDNQSPMPQQEQQH

Sequences:

>Translated_444_residues
MSVYYTLCFLSAAAMLIAFINSKISRMQTTIAITAGSMMLSLLILIAGQNDWFHLNQIATETVTSINFENFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFTLYGFCQLIGIQFDLVYCLLFGALISPTDPIAVLAIVKKLKAP
KRISTQIEGESLFNDGFGLVIFVTIFTIAFGHETPTVGSVTLLFIQEAIGGIVYGFLLGLLFHYLISATDDHSMELLLTI
GIPTAGYAFADVIHVSGPLAMVVSGIMIGNWTRFIGFSKESEEHLDHFWELVDEFLNGVLFLLIGMSMLLFEFHQEDWIL
MAFAVPLVLCGRYLSVFVSYIGFKRYRSYNPWSIRILTWGGLRGGLALAMALSIPSGIMVIPEKLIDVKELILVMTYAVV
VFSILVQGSTITPMIEKAKKAEKALQAERNTDNQSPMPQQEQQH
>Mature_443_residues
SVYYTLCFLSAAAMLIAFINSKISRMQTTIAITAGSMMLSLLILIAGQNDWFHLNQIATETVTSINFENFLLKGILGFLL
FAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFTLYGFCQLIGIQFDLVYCLLFGALISPTDPIAVLAIVKKLKAPK
RISTQIEGESLFNDGFGLVIFVTIFTIAFGHETPTVGSVTLLFIQEAIGGIVYGFLLGLLFHYLISATDDHSMELLLTIG
IPTAGYAFADVIHVSGPLAMVVSGIMIGNWTRFIGFSKESEEHLDHFWELVDEFLNGVLFLLIGMSMLLFEFHQEDWILM
AFAVPLVLCGRYLSVFVSYIGFKRYRSYNPWSIRILTWGGLRGGLALAMALSIPSGIMVIPEKLIDVKELILVMTYAVVV
FSILVQGSTITPMIEKAKKAEKALQAERNTDNQSPMPQQEQQH

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=333, Percent_Identity=25.5255255255255, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI15529998, Length=339, Percent_Identity=27.4336283185841, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI41872703, Length=445, Percent_Identity=23.5955056179775, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI27734935, Length=358, Percent_Identity=25.4189944134078, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI27777632, Length=353, Percent_Identity=23.7960339943343, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI294997330, Length=394, Percent_Identity=22.8426395939086, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI110227626, Length=394, Percent_Identity=22.8426395939086, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI5454070, Length=354, Percent_Identity=22.8813559322034, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI194239733, Length=390, Percent_Identity=24.8717948717949, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI14211919, Length=355, Percent_Identity=24.2253521126761, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4759144, Length=359, Percent_Identity=25.3481894150418, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790501, Length=346, Percent_Identity=28.6127167630058, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71999819, Length=401, Percent_Identity=24.6882793017456, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71999821, Length=401, Percent_Identity=24.6882793017456, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71999817, Length=401, Percent_Identity=24.6882793017456, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71987535, Length=348, Percent_Identity=25.5747126436782, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71987537, Length=348, Percent_Identity=25.5747126436782, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71990924, Length=368, Percent_Identity=24.7282608695652, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71990932, Length=368, Percent_Identity=24.7282608695652, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980847, Length=363, Percent_Identity=25.3443526170799, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25150332, Length=334, Percent_Identity=22.4550898203593, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71992107, Length=376, Percent_Identity=24.2021276595745, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71992101, Length=376, Percent_Identity=24.2021276595745, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI25147678, Length=294, Percent_Identity=26.8707482993197, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993590, Length=416, Percent_Identity=25, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=416, Percent_Identity=25, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71987559, Length=336, Percent_Identity=22.3214285714286, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=336, Percent_Identity=22.3214285714286, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=343, Percent_Identity=26.2390670553936, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI221510734, Length=350, Percent_Identity=24.5714285714286, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221510738, Length=350, Percent_Identity=24.5714285714286, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221473212, Length=352, Percent_Identity=25.5681818181818, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281364513, Length=352, Percent_Identity=25.5681818181818, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281360447, Length=369, Percent_Identity=23.5772357723577, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221473215, Length=352, Percent_Identity=25.5681818181818, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221473222, Length=352, Percent_Identity=25.5681818181818, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221510736, Length=350, Percent_Identity=24.8571428571429, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221510732, Length=350, Percent_Identity=24.8571428571429, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585580, Length=350, Percent_Identity=24.8571428571429, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585578, Length=350, Percent_Identity=24.8571428571429, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510740, Length=350, Percent_Identity=24.8571428571429, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 49152; Mature: 49021

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYYTLCFLSAAAMLIAFINSKISRMQTTIAITAGSMMLSLLILIAGQNDWFHLNQIAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
ETVTSINFENFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFTLY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GFCQLIGIQFDLVYCLLFGALISPTDPIAVLAIVKKLKAPKRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHCCCCHHH
IFVTIFTIAFGHETPTVGSVTLLFIQEAIGGIVYGFLLGLLFHYLISATDDHSMELLLTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
GIPTAGYAFADVIHVSGPLAMVVSGIMIGNWTRFIGFSKESEEHLDHFWELVDEFLNGVL
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFEFHQEDWILMAFAVPLVLCGRYLSVFVSYIGFKRYRSYNPWSIRILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIMVIPEKLIDVKELILVMTYAVVVFSILVQGSTITPMIEKAKK
CCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AEKALQAERNTDNQSPMPQQEQQH
HHHHHHHHCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
SVYYTLCFLSAAAMLIAFINSKISRMQTTIAITAGSMMLSLLILIAGQNDWFHLNQIAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
ETVTSINFENFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFTLY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GFCQLIGIQFDLVYCLLFGALISPTDPIAVLAIVKKLKAPKRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHCCCCHHH
IFVTIFTIAFGHETPTVGSVTLLFIQEAIGGIVYGFLLGLLFHYLISATDDHSMELLLTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
GIPTAGYAFADVIHVSGPLAMVVSGIMIGNWTRFIGFSKESEEHLDHFWELVDEFLNGVL
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFEFHQEDWILMAFAVPLVLCGRYLSVFVSYIGFKRYRSYNPWSIRILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIMVIPEKLIDVKELILVMTYAVVVFSILVQGSTITPMIEKAKK
CCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AEKALQAERNTDNQSPMPQQEQQH
HHHHHHHHCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]