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The map label for this gene is cadA [H]

Identifier: 227080495

GI number: 227080495

Start: 271760

End: 273961

Strand: Direct

Name: cadA [H]

Synonym: VCM66_0266

Alternate gene names: 227080495

Gene position: 271760-273961 (Clockwise)

Preceding gene: 227080494

Following gene: 227080501

Centisome position: 9.4

GC content: 50.09

Gene sequence:

>2202_bases
ATGGCGCTCGTCTTACTCACTGTGCAGTGCACAGAGAGCGCCTTTTTTCGCCTTGGAGATGTCCAAATGAATATTTTCGC
TATCTTGAACCACATGGGTGTGTTCTTTAAAGAAGAGCCTGTTCGCCAACTGCATGCAGCATTAGAAAAAGCCGGTTACG
ACGTGGTTTATCCGGTGGATGACAAAGATCTGATCAAGATGATTGAGATGAACCCACGCATTTGCGGCGTGCTGTTCGAC
TGGGATAAATACTCGCTAGAGCTGTGTGAGCGCATCAGTAAAGTCAATGAAAAACTGCCTGTGCACGCCTTTGCTAACGA
GCAATCGACGTTAGATATTTCGCTAACCGATCTGCGCCTCAACGTGCATTTCTTCGAATACGCTCTGGGCATGGCCGACG
ATATCGCCATCAAGATCAATCAAGCGACTCAAGAGTACAAAGACGCGATCATGCCTCCGTTTACTAAGGCGCTGTTCAAA
TATGTAGAAGAGGGTAAATACACCTTCTGTACTCCGGGCCATATGGGCGGTACTGCGTTCCAGAAAAGCCCTGTTGGCAG
CATTTTCTACGATTTCTACGGTCCAAATACCTTCAAAGCGGACGTATCGATTTCGATGCCAGAACTGGGCTCACTGCTCG
ATCACTCCGGTCCACACAAAGAAGCGGAAGAGTACATCGCGCGCACGTTCAATGCCGATGCTTCTTACATCGTGACCAAC
GGTACATCGACCTCGAACAAGATCGTCGGTATGTTCTCCGCGCCTGCGGGTAGCACAGTGCTGGTGGATCGTAACTGCCA
TAAATCATTGACTCACTTAATGATGATGACGGATGTAACGCCAATTTACTTCCGTCCAACCCGTAACGCTTACGGCATTC
TTGGTGGTATTCCACAGAACGAATTCAGCCGTGAAGTGATTGCAGAGAAAGTGGCAAACACCCCGGGGGCGAGCGCACCA
AGCTACGCGGTGATCACCAACTCGACTTACGATGGCCTGCTGTACAACACTCAGTTCATTAAAGAGTCGCTGGATTGCAA
ACACATCCACTTCGACAGTGCATGGGTGCCTTACACTAACTTCAACCGTATTTATGAAGGCAAGTGCGGCATGAGTGGCG
AAGCGATGCCGGGTAAAGTGTTCTACGAAACCCAGTCCACGCACAAACTGCTGGCGGCGTTCTCGCAAGCCTCGATGATT
CATGTCAAAGGTGAGTTTGACCGCGAGTCGTTCAACGAAGCCTTTATGATGCACACCTCAACCTCACCGCAGTACGGCAT
TGTGGCATCGACGGAAACTGCCGCTGCAATGATGCGTGGCAACACCGGCCGTAAGCTTATGCAGGATTCGATTGATCGTG
CGATTCGCTTCCGTAAAGAGATCAAACGTCTGAAAGGCGAGAGCGAAGGCTGGTTCTTCGATGTGTGGCAACCCGAGAAC
ATTGAGACCACCGAGTGCTGGAAACTCGATCCAAACCAAGATTGGCACGGCTTCAAGAATCTTGATGACAACCACATGTA
CCTTGACCCCATCAAAATCACTCTGCTGACTCCGGGAATGAGCAAAGATGGCGAATTGGAGCAGAGCGGTATTCCGGCAT
CACTGGTCTCTAAATACCTTGATGAACACGGTATCGTGGTTGAGAAAACTGGCCCTTACAACCTGCTGTTCCTGTTCTCT
ATCGGTATTGATAAGTCAAAAGCGATGCAGTTGCTGCGCGGCTTGACGGAGTTCAAACGCGGTTACGATCTGAACCTGAC
CATTCGTACCATGCTGCCTTCACTGTACCGTGAAGACCCAGCTTTCTACGAAGGCATGCGTATTCAAGAGTTGGCGCAAG
GCATTCACGACTTAACTCGTAAATACCAATTGCCAGAGCTGATGTACAAAGCGTTCGATGTGCTGCCAGAGATGAAAGTG
ACGCCACACGTGGCATGGCAACAAGAGCTGCGCGGTCAAACTGAAGAGATCCTGCTTAACGAGATGGTGGGTCGCGTGAG
CGCCAATATGATCCTGCCTTATCCTCCAGGCGTGCCATTGGTACTGCCAGGTGAAATGGTGACAGACAGCTCTCGCCCTG
TGTTGGATTTCTTGGAAATGCTGTGCGAAATCGGCGCGCATTACCCAGGTTTTGAGACCGACATTCATGGTTTGTATCGC
CAAAAAGATGGCTCTTACACCGTAAAAGTGCTGAAGGACTAA

Upstream 100 bases:

>100_bases
GCGGGTCTGGATAAATACCTCGAGACTCATCCACAACAAGCTTCGGCTCAGTTCTGATTGACCTTGCTGGCGTCTGCCAC
GCCAGCTTTCTGAATTCACT

Downstream 100 bases:

>100_bases
GCCAGCTTTACCCCATAAAGACAGCGTAACTCCCCAATGGACGCTGATACACAGAGAGAGCCTCACGGCTCTCTCTTTTT
TCATGGTGCAATTTAGGTGA

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MALVLLTVQCTESAFFRLGDVQMNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVDDKDLIKMIEMNPRICGVLFD
WDKYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRLNVHFFEYALGMADDIAIKINQATQEYKDAIMPPFTKALFK
YVEEGKYTFCTPGHMGGTAFQKSPVGSIFYDFYGPNTFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTN
GTSTSNKIVGMFSAPAGSTVLVDRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQNEFSREVIAEKVANTPGASAP
SYAVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTNFNRIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMI
HVKGEFDRESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNTGRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPEN
IETTECWKLDPNQDWHGFKNLDDNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYLDEHGIVVEKTGPYNLLFLFS
IGIDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDPAFYEGMRIQELAQGIHDLTRKYQLPELMYKAFDVLPEMKV
TPHVAWQQELRGQTEEILLNEMVGRVSANMILPYPPGVPLVLPGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYR
QKDGSYTVKVLKD

Sequences:

>Translated_733_residues
MALVLLTVQCTESAFFRLGDVQMNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVDDKDLIKMIEMNPRICGVLFD
WDKYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRLNVHFFEYALGMADDIAIKINQATQEYKDAIMPPFTKALFK
YVEEGKYTFCTPGHMGGTAFQKSPVGSIFYDFYGPNTFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTN
GTSTSNKIVGMFSAPAGSTVLVDRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQNEFSREVIAEKVANTPGASAP
SYAVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTNFNRIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMI
HVKGEFDRESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNTGRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPEN
IETTECWKLDPNQDWHGFKNLDDNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYLDEHGIVVEKTGPYNLLFLFS
IGIDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDPAFYEGMRIQELAQGIHDLTRKYQLPELMYKAFDVLPEMKV
TPHVAWQQELRGQTEEILLNEMVGRVSANMILPYPPGVPLVLPGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYR
QKDGSYTVKVLKD
>Mature_732_residues
ALVLLTVQCTESAFFRLGDVQMNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVDDKDLIKMIEMNPRICGVLFDW
DKYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRLNVHFFEYALGMADDIAIKINQATQEYKDAIMPPFTKALFKY
VEEGKYTFCTPGHMGGTAFQKSPVGSIFYDFYGPNTFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTNG
TSTSNKIVGMFSAPAGSTVLVDRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQNEFSREVIAEKVANTPGASAPS
YAVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTNFNRIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIH
VKGEFDRESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNTGRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPENI
ETTECWKLDPNQDWHGFKNLDDNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYLDEHGIVVEKTGPYNLLFLFSI
GIDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDPAFYEGMRIQELAQGIHDLTRKYQLPELMYKAFDVLPEMKVT
PHVAWQQELRGQTEEILLNEMVGRVSANMILPYPPGVPLVLPGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYRQ
KDGSYTVKVLKD

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=711, Percent_Identity=75.2461322081575, Blast_Score=1170, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=67.1830985915493, Blast_Score=1052, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=36.4625850340136, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI87082193, Length=622, Percent_Identity=33.2797427652733, Blast_Score=337, Evalue=2e-93,
Organism=Escherichia coli, GI1786909, Length=625, Percent_Identity=34.24, Blast_Score=334, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 82870; Mature: 82739

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00703 OKR_DC_1 ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVLLTVQCTESAFFRLGDVQMNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVD
CEEEEEEEEECCCHHEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECC
DKDLIKMIEMNPRICGVLFDWDKYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRL
CHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEEE
NVHFFEYALGMADDIAIKINQATQEYKDAIMPPFTKALFKYVEEGKYTFCTPGHMGGTAF
EEEHHHHHHCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCC
QKSPVGSIFYDFYGPNTFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTN
CCCCCCCEEEEECCCCEEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEC
GTSTSNKIVGMFSAPAGSTVLVDRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQN
CCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCH
EFSREVIAEKVANTPGASAPSYAVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCC
FNRIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDRESFNEAFMMHTS
CCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEEC
TSPQYGIVASTETAAAMMRGNTGRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPEN
CCCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
IETTECWKLDPNQDWHGFKNLDDNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYL
CCCCEEEECCCCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
DEHGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDP
HHCCEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
AFYEGMRIQELAQGIHDLTRKYQLPELMYKAFDVLPEMKVTPHVAWQQELRGQTEEILLN
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHH
EMVGRVSANMILPYPPGVPLVLPGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYR
HHHHHHCCCEEEECCCCCCEEECCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHC
QKDGSYTVKVLKD
CCCCCEEEEEECC
>Mature Secondary Structure 
ALVLLTVQCTESAFFRLGDVQMNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVD
EEEEEEEEECCCHHEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECC
DKDLIKMIEMNPRICGVLFDWDKYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRL
CHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEEE
NVHFFEYALGMADDIAIKINQATQEYKDAIMPPFTKALFKYVEEGKYTFCTPGHMGGTAF
EEEHHHHHHCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCC
QKSPVGSIFYDFYGPNTFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTN
CCCCCCCEEEEECCCCEEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEC
GTSTSNKIVGMFSAPAGSTVLVDRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQN
CCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCH
EFSREVIAEKVANTPGASAPSYAVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCC
FNRIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDRESFNEAFMMHTS
CCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEEC
TSPQYGIVASTETAAAMMRGNTGRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPEN
CCCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
IETTECWKLDPNQDWHGFKNLDDNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYL
CCCCEEEECCCCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
DEHGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDP
HHCCEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
AFYEGMRIQELAQGIHDLTRKYQLPELMYKAFDVLPEMKVTPHVAWQQELRGQTEEILLN
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHH
EMVGRVSANMILPYPPGVPLVLPGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYR
HHHHHHCCCEEEECCCCCCEEECCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHC
QKDGSYTVKVLKD
CCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]