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The map label for this gene is fhuD [H]

Identifier: 227080424

GI number: 227080424

Start: 196444

End: 198405

Strand: Direct

Name: fhuD [H]

Synonym: VCM66_0191

Alternate gene names: 227080424

Gene position: 196444-198405 (Clockwise)

Preceding gene: 227080423

Following gene: 227080426

Centisome position: 6.79

GC content: 56.01

Gene sequence:

>1962_bases
ATGAGTGTGCTGCGTTTAACTGGTTTGGGGGCGCTGACTCTGCTGTTGGCGCTGGTGAGTGTGCAGTGGGGGCACAATTT
AACTCTCAATGAGCAGTGGCAATTGGTGCTCGGTCATCAAGCCGCGCAAAGTTTCGCGCAGGTGAATTTTATCTACGCGC
AGCTACCCCGTGCGGTGATGGCCATAGTGGTGGGCGCTGTGCTTGGGTTGGTGGGCAGCTTGATGCAGCAGTTGACCCAA
AACCGACTCACCTCACCGCTGACGTTGGGAACCTCATCCGGTGCTTGGTTGGGGCTGATTATCGTCAATATCTGGTTCAG
TGATTGGGTGGCCGATTACAGCGCATTGGCTGCGATGGCTGGAGCACTGCTCGCTTTCGCACTGATAATTTCGATTGCGG
GGTTACGCAATCTCACCGGATTACCGCTAGTCGTTTCCGGCATGGTGGTGAACATTTTGCTGGGTTCGATTGCCACGGCC
TTGGTGCTGCTGAACGAAGAGTTCGCCCAGAATGTATTTATGTGGGGTGCTGGTGATTTAGCGCAAAACGGTTGGGAGTG
GCTCACTTGGTTGCTGCCGCGTTTGGCTTTGGTCATTCCCTTACTGCTTTTTGCACCGCGAGTGCTGACTTTGCTTCGGC
TCGGCCATGAAGGGGCGGCGGCGCGTGGTTTAGCGGTATTGCCTGCCTTTTTACTTTTGATGGCGGGTGGGATTTGGTTG
GTATCCGTATCGATTACTGCGGTTGGAGTGATCGGTTTTATCGGTTTATTAACCCCGAATATCGCCCGTTCACTGGGGGC
GCGCACGCCAAAAATGGAGTTGTACAGCAGTGCACTGCTTGGTGCGTTGTTGCTGCTTACCACTGACATGCTCGCCATGG
GGCTGAGCGTGTGGGCGGAGGAAGTGGTGCCTAGCGGCATTACCGCTGCCGTGATTGGTGCTCCGGCGCTGATCTGGTTT
AGTCGTCGCCAGCTCCAGGCGCAGGATTCGCTCTCTATCTCCTTGTCTTCACATCGCCGTTCGCCTTCTCGATGGGCGGT
GATGCTCATTGCGGCGGCTTTGTTGTTGGCTCTGGGTTTACATATTGGTTGGCAGATGGAAAGTGCAAGCTGGGCGCTGC
CGAGTGAGTTTCAATGGCCGCTTCGTTGGCCGCGCATGCTCACCGCGCTGTTTGCTGGGGTGGGATTGGCGATCGCGGGA
ACGTTACTGCAACGGCTGATTTATAACCCGTTAGCCAGCCCTGATATTTTGGGCGTCTCTTCGGGGGCTACGTTTGCCTT
GGTGTTTGCTAGCTTGTTTTTAGGGCAAAGTTTGCAGAGCACCCACTGGATGACGGCGCTGCTTGGCAGCGCTGCGGTAT
TGGTGGTGCTCTTGCTGCTTGGGCGGCGCCATCATTACGCACCGTCTAGCTTGATCTTGACTGGGATTGCCATCACCGCA
CTGCTGGAAGCCTTGGTGCAATTTACCTTGGCCAAAGGAACGGGCGACAGCTATCAGATTTTGCTGTGGCTATCGGGTTC
AACTTATCGTGTCACGGGCGAGCAAGCTTTGCTACTCAGCGTGGGTGTGGTGGGGTTAACACTGTTGGCGCTTGGCTTGT
CTCGTTGGCTTACCTTGATCTCGATTGGGCGCGGCTTTGCTTCTGCCCGCGGCTTGAGTGCGAGTCGCGCCAGCTTGGTG
CTATTGATCTTGGTGGCAGCTTTGTGCGCCTTGGTCACAGCCACCATGGGCCCCGTCAGCTTTGTTGGTTTGATTGCGCC
TCACATGGCGATGATGCTCGGCGCGCAGCGTGCTCCATCTCAACTTCTGCTCGCTGCCTTGGTCGGTGGTACTTTGATGT
TGTGGGCAGACTGGTTGGGGCAAGCCTTGTTATTCCCCGCGCAAATTGCCGCAGGCACGCTAGTGGCAATCATTGGTGGC
AGCTATTTCCTGCTGCTGTTACTCAGTCAGCGTGCACGCTAA

Upstream 100 bases:

>100_bases
TCAATTCCGTGCGTTCCGTGTGGAGCTATGGCGGGGCGATGTCACTGCGTTATAGCGCAGAAGCGATCACCGAAAGCTTG
CTGGCGGTGGCTCCGCAATC

Downstream 100 bases:

>100_bases
ACCCTCAGTTGAGAGGCGCTTGCCTCTCAACGCATCTGGCGAATGTCGGAAGAAATGTCATCGATCAACTGCCGCGCGGA
CGTTTCACGCTGCTGAGTGA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MSVLRLTGLGALTLLLALVSVQWGHNLTLNEQWQLVLGHQAAQSFAQVNFIYAQLPRAVMAIVVGAVLGLVGSLMQQLTQ
NRLTSPLTLGTSSGAWLGLIIVNIWFSDWVADYSALAAMAGALLAFALIISIAGLRNLTGLPLVVSGMVVNILLGSIATA
LVLLNEEFAQNVFMWGAGDLAQNGWEWLTWLLPRLALVIPLLLFAPRVLTLLRLGHEGAAARGLAVLPAFLLLMAGGIWL
VSVSITAVGVIGFIGLLTPNIARSLGARTPKMELYSSALLGALLLLTTDMLAMGLSVWAEEVVPSGITAAVIGAPALIWF
SRRQLQAQDSLSISLSSHRRSPSRWAVMLIAAALLLALGLHIGWQMESASWALPSEFQWPLRWPRMLTALFAGVGLAIAG
TLLQRLIYNPLASPDILGVSSGATFALVFASLFLGQSLQSTHWMTALLGSAAVLVVLLLLGRRHHYAPSSLILTGIAITA
LLEALVQFTLAKGTGDSYQILLWLSGSTYRVTGEQALLLSVGVVGLTLLALGLSRWLTLISIGRGFASARGLSASRASLV
LLILVAALCALVTATMGPVSFVGLIAPHMAMMLGAQRAPSQLLLAALVGGTLMLWADWLGQALLFPAQIAAGTLVAIIGG
SYFLLLLLSQRAR

Sequences:

>Translated_653_residues
MSVLRLTGLGALTLLLALVSVQWGHNLTLNEQWQLVLGHQAAQSFAQVNFIYAQLPRAVMAIVVGAVLGLVGSLMQQLTQ
NRLTSPLTLGTSSGAWLGLIIVNIWFSDWVADYSALAAMAGALLAFALIISIAGLRNLTGLPLVVSGMVVNILLGSIATA
LVLLNEEFAQNVFMWGAGDLAQNGWEWLTWLLPRLALVIPLLLFAPRVLTLLRLGHEGAAARGLAVLPAFLLLMAGGIWL
VSVSITAVGVIGFIGLLTPNIARSLGARTPKMELYSSALLGALLLLTTDMLAMGLSVWAEEVVPSGITAAVIGAPALIWF
SRRQLQAQDSLSISLSSHRRSPSRWAVMLIAAALLLALGLHIGWQMESASWALPSEFQWPLRWPRMLTALFAGVGLAIAG
TLLQRLIYNPLASPDILGVSSGATFALVFASLFLGQSLQSTHWMTALLGSAAVLVVLLLLGRRHHYAPSSLILTGIAITA
LLEALVQFTLAKGTGDSYQILLWLSGSTYRVTGEQALLLSVGVVGLTLLALGLSRWLTLISIGRGFASARGLSASRASLV
LLILVAALCALVTATMGPVSFVGLIAPHMAMMLGAQRAPSQLLLAALVGGTLMLWADWLGQALLFPAQIAAGTLVAIIGG
SYFLLLLLSQRAR
>Mature_652_residues
SVLRLTGLGALTLLLALVSVQWGHNLTLNEQWQLVLGHQAAQSFAQVNFIYAQLPRAVMAIVVGAVLGLVGSLMQQLTQN
RLTSPLTLGTSSGAWLGLIIVNIWFSDWVADYSALAAMAGALLAFALIISIAGLRNLTGLPLVVSGMVVNILLGSIATAL
VLLNEEFAQNVFMWGAGDLAQNGWEWLTWLLPRLALVIPLLLFAPRVLTLLRLGHEGAAARGLAVLPAFLLLMAGGIWLV
SVSITAVGVIGFIGLLTPNIARSLGARTPKMELYSSALLGALLLLTTDMLAMGLSVWAEEVVPSGITAAVIGAPALIWFS
RRQLQAQDSLSISLSSHRRSPSRWAVMLIAAALLLALGLHIGWQMESASWALPSEFQWPLRWPRMLTALFAGVGLAIAGT
LLQRLIYNPLASPDILGVSSGATFALVFASLFLGQSLQSTHWMTALLGSAAVLVVLLLLGRRHHYAPSSLILTGIAITAL
LEALVQFTLAKGTGDSYQILLWLSGSTYRVTGEQALLLSVGVVGLTLLALGLSRWLTLISIGRGFASARGLSASRASLVL
LILVAALCALVTATMGPVSFVGLIAPHMAMMLGAQRAPSQLLLAALVGGTLMLWADWLGQALLFPAQIAAGTLVAIIGGS
YFLLLLLSQRAR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=644, Percent_Identity=35.7142857142857, Blast_Score=281, Evalue=1e-76,
Organism=Escherichia coli, GI1790740, Length=305, Percent_Identity=34.0983606557377, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1790741, Length=275, Percent_Identity=35.2727272727273, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1786804, Length=277, Percent_Identity=32.129963898917, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788004, Length=234, Percent_Identity=31.6239316239316, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786805, Length=278, Percent_Identity=34.1726618705036, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 68992; Mature: 68861

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLRLTGLGALTLLLALVSVQWGHNLTLNEQWQLVLGHQAAQSFAQVNFIYAQLPRAVM
CCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVVGAVLGLVGSLMQQLTQNRLTSPLTLGTSSGAWLGLIIVNIWFSDWVADYSALAAMA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GALLAFALIISIAGLRNLTGLPLVVSGMVVNILLGSIATALVLLNEEFAQNVFMWGAGDL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
AQNGWEWLTWLLPRLALVIPLLLFAPRVLTLLRLGHEGAAARGLAVLPAFLLLMAGGIWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHE
VSVSITAVGVIGFIGLLTPNIARSLGARTPKMELYSSALLGALLLLTTDMLAMGLSVWAE
EHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPSGITAAVIGAPALIWFSRRQLQAQDSLSISLSSHRRSPSRWAVMLIAAALLLALGL
HHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHH
HIGWQMESASWALPSEFQWPLRWPRMLTALFAGVGLAIAGTLLQRLIYNPLASPDILGVS
HCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECC
SGATFALVFASLFLGQSLQSTHWMTALLGSAAVLVVLLLLGRRHHYAPSSLILTGIAITA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLEALVQFTLAKGTGDSYQILLWLSGSTYRVTGEQALLLSVGVVGLTLLALGLSRWLTLI
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGRGFASARGLSASRASLVLLILVAALCALVTATMGPVSFVGLIAPHMAMMLGAQRAPS
HHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
QLLLAALVGGTLMLWADWLGQALLFPAQIAAGTLVAIIGGSYFLLLLLSQRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLRLTGLGALTLLLALVSVQWGHNLTLNEQWQLVLGHQAAQSFAQVNFIYAQLPRAVM
CCEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVVGAVLGLVGSLMQQLTQNRLTSPLTLGTSSGAWLGLIIVNIWFSDWVADYSALAAMA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GALLAFALIISIAGLRNLTGLPLVVSGMVVNILLGSIATALVLLNEEFAQNVFMWGAGDL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
AQNGWEWLTWLLPRLALVIPLLLFAPRVLTLLRLGHEGAAARGLAVLPAFLLLMAGGIWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHE
VSVSITAVGVIGFIGLLTPNIARSLGARTPKMELYSSALLGALLLLTTDMLAMGLSVWAE
EHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPSGITAAVIGAPALIWFSRRQLQAQDSLSISLSSHRRSPSRWAVMLIAAALLLALGL
HHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHH
HIGWQMESASWALPSEFQWPLRWPRMLTALFAGVGLAIAGTLLQRLIYNPLASPDILGVS
HCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECC
SGATFALVFASLFLGQSLQSTHWMTALLGSAAVLVVLLLLGRRHHYAPSSLILTGIAITA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLEALVQFTLAKGTGDSYQILLWLSGSTYRVTGEQALLLSVGVVGLTLLALGLSRWLTLI
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGRGFASARGLSASRASLVLLILVAALCALVTATMGPVSFVGLIAPHMAMMLGAQRAPS
HHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
QLLLAALVGGTLMLWADWLGQALLFPAQIAAGTLVAIIGGSYFLLLLLSQRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]