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The map label for this gene is fhuC [H]

Identifier: 227080423

GI number: 227080423

Start: 195488

End: 196447

Strand: Direct

Name: fhuC [H]

Synonym: VCM66_0190

Alternate gene names: 227080423

Gene position: 195488-196447 (Clockwise)

Preceding gene: 227080422

Following gene: 227080424

Centisome position: 6.76

GC content: 52.71

Gene sequence:

>960_bases
ATGTGCTTGATGAGTTTATGGAATGTTCGTTTACGGAACATTTGCCAACCGAAGGCGGTTTTTGGCTGGCTTGCCGCGCT
TTGCCTATTCGCACTGCCCGTGCAAGCACAAATTGTGCTGACGGATAGCCAAGGTACGCACACTTTTGCTGAGGTTCCAC
AGCGAGTGGTGGTACTGAACTGGGATCTGCTTGAACAAGTGCTTGAACTGGGCATTCAACCCGTCGGCGCGCCAGAATTG
AGTTCTTACGTGCAGTGGGTTGTGCAACCCGAGGTGCCAAGTTCGGTGCAAGATATTGGAACCCGTACTGAGCCGAATTT
AGAGAAAATCGCTGCGCTCAAACCGGATTTCATTTTAGCCGCAGGGCCGCAACAAGATTTGCTGGCCACCTTAGGGCGCA
TTGCGCCAGTGGTGTATTTGCCCAACTTTGCTGAGCAAGATAACGCTGCCCAAGTGGCGATTTCCCACTTTAAAACCTTA
GCTACTTTGTTTGGTAAAGAGGCGGTGGCGCAGCAAAAACTGGAGGCGATGTATGCCCGTTTTGCTGAGCTGAAAGCTTC
GCTACAGCACGCCTTTGGTGACACTTTACCTGCGGTGGTGACGCTGCGTTTTGCCAACCCAACCTCGGTGTTTTTGTATA
CCGAAAACTCCACGCCGCAATATGTGCTAGAACAGCTCGGTTTATCGTCAGCGCTGCCGCAGCCGCCGAAAGAGTGGGGC
ATAGTGCAAAAACGCTTGAGTGAGTTGCAACACGTTGAGCAAGGCTATGTGCTCTATTTCTTGCCGTTTGCGGAAGAGAA
AAAAGTGCAAAAATCGGTGCTGTGGCGAGCGATGCCGTTTGTGCAAGCGGGGCGTGTCAATTCCGTGCGTTCCGTGTGGA
GCTATGGCGGGGCGATGTCACTGCGTTATAGCGCAGAAGCGATCACCGAAAGCTTGCTGGCGGTGGCTCCGCAATCATGA

Upstream 100 bases:

>100_bases
TCGATGAACAGCGGCTGTCCGAGTTGTATCACTCACCGATTCGTTTGATCGATCACCCGAATCCCATTTCCCACTCCTCT
ACTAATAAGGTTGCGATCGT

Downstream 100 bases:

>100_bases
GTGTGCTGCGTTTAACTGGTTTGGGGGCGCTGACTCTGCTGTTGGCGCTGGTGAGTGTGCAGTGGGGGCACAATTTAACT
CTCAATGAGCAGTGGCAATT

Product: iron(III) ABC transporter, periplasmic iron-compound-binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MCLMSLWNVRLRNICQPKAVFGWLAALCLFALPVQAQIVLTDSQGTHTFAEVPQRVVVLNWDLLEQVLELGIQPVGAPEL
SSYVQWVVQPEVPSSVQDIGTRTEPNLEKIAALKPDFILAAGPQQDLLATLGRIAPVVYLPNFAEQDNAAQVAISHFKTL
ATLFGKEAVAQQKLEAMYARFAELKASLQHAFGDTLPAVVTLRFANPTSVFLYTENSTPQYVLEQLGLSSALPQPPKEWG
IVQKRLSELQHVEQGYVLYFLPFAEEKKVQKSVLWRAMPFVQAGRVNSVRSVWSYGGAMSLRYSAEAITESLLAVAPQS

Sequences:

>Translated_319_residues
MCLMSLWNVRLRNICQPKAVFGWLAALCLFALPVQAQIVLTDSQGTHTFAEVPQRVVVLNWDLLEQVLELGIQPVGAPEL
SSYVQWVVQPEVPSSVQDIGTRTEPNLEKIAALKPDFILAAGPQQDLLATLGRIAPVVYLPNFAEQDNAAQVAISHFKTL
ATLFGKEAVAQQKLEAMYARFAELKASLQHAFGDTLPAVVTLRFANPTSVFLYTENSTPQYVLEQLGLSSALPQPPKEWG
IVQKRLSELQHVEQGYVLYFLPFAEEKKVQKSVLWRAMPFVQAGRVNSVRSVWSYGGAMSLRYSAEAITESLLAVAPQS
>Mature_319_residues
MCLMSLWNVRLRNICQPKAVFGWLAALCLFALPVQAQIVLTDSQGTHTFAEVPQRVVVLNWDLLEQVLELGIQPVGAPEL
SSYVQWVVQPEVPSSVQDIGTRTEPNLEKIAALKPDFILAAGPQQDLLATLGRIAPVVYLPNFAEQDNAAQVAISHFKTL
ATLFGKEAVAQQKLEAMYARFAELKASLQHAFGDTLPAVVTLRFANPTSVFLYTENSTPQYVLEQLGLSSALPQPPKEWG
IVQKRLSELQHVEQGYVLYFLPFAEEKKVQKSVLWRAMPFVQAGRVNSVRSVWSYGGAMSLRYSAEAITESLLAVAPQS

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=261, Percent_Identity=31.4176245210728, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082411, Length=261, Percent_Identity=28.3524904214559, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 35264; Mature: 35264

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLMSLWNVRLRNICQPKAVFGWLAALCLFALPVQAQIVLTDSQGTHTFAEVPQRVVVLN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCEEEEEC
WDLLEQVLELGIQPVGAPELSSYVQWVVQPEVPSSVQDIGTRTEPNLEKIAALKPDFILA
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEE
AGPQQDLLATLGRIAPVVYLPNFAEQDNAAQVAISHFKTLATLFGKEAVAQQKLEAMYAR
CCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAELKASLQHAFGDTLPAVVTLRFANPTSVFLYTENSTPQYVLEQLGLSSALPQPPKEWG
HHHHHHHHHHHHCCCCCHHEEEEECCCCEEEEEECCCCHHHHHHHHCHHHCCCCCCHHHH
IVQKRLSELQHVEQGYVLYFLPFAEEKKVQKSVLWRAMPFVQAGRVNSVRSVWSYGGAMS
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
LRYSAEAITESLLAVAPQS
EEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCLMSLWNVRLRNICQPKAVFGWLAALCLFALPVQAQIVLTDSQGTHTFAEVPQRVVVLN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCEEEEEC
WDLLEQVLELGIQPVGAPELSSYVQWVVQPEVPSSVQDIGTRTEPNLEKIAALKPDFILA
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEE
AGPQQDLLATLGRIAPVVYLPNFAEQDNAAQVAISHFKTLATLFGKEAVAQQKLEAMYAR
CCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAELKASLQHAFGDTLPAVVTLRFANPTSVFLYTENSTPQYVLEQLGLSSALPQPPKEWG
HHHHHHHHHHHHCCCCCHHEEEEECCCCEEEEEECCCCHHHHHHHHCHHHCCCCCCHHHH
IVQKRLSELQHVEQGYVLYFLPFAEEKKVQKSVLWRAMPFVQAGRVNSVRSVWSYGGAMS
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
LRYSAEAITESLLAVAPQS
EEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]