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The map label for this gene is ilvC

Identifier: 227080395

GI number: 227080395

Start: 157693

End: 159177

Strand: Direct

Name: ilvC

Synonym: VCM66_0161

Alternate gene names: 227080395

Gene position: 157693-159177 (Clockwise)

Preceding gene: 227080392

Following gene: 227080400

Centisome position: 5.45

GC content: 47.61

Gene sequence:

>1485_bases
ATGGCGAATTATTTCAATACGCTGAATCTGCGTGAACAGTTGGATCAACTTGGTCGTTGCCGTTTTATGGCGCGAGAAGA
GTTTGCAACCGAAGCTGATTACCTAAAAGGTAAGAAAGTGGTGATCGTAGGTTGTGGGGCTCAAGGCCTAAACCAAGGCC
TCAATATGCGTGATTCAGGTTTGGATGTTTCTTACGCTCTGCGTCAGGCTGCGATTGATGAACAGCGTCAGTCATTTAAG
AATGCCAAGAATAATGGCTTCAACGTGGGTAGTTATGAACAACTCATCCCAACCGCAGATTTGGTGATTAACTTGACGCC
AGATAAGCAGCACACCAGTGTGGTCAATGCGGTGATGCCTCTGATGAAGCAAGGTGCTGCCTTGGGTTACTCACACGGTT
TTAATATCGTTGAAGAGGGCATGCAGATCCGTAAAGACATCACGGTTGTGATGGTGGCACCAAAATGTCCGGGTACGGAA
GTTCGTGAAGAGTATAAGCGCGGTTTCGGCGTTCCTACTCTTATCGCGGTACACCCTGAAAACGATCCACAAGGTGAAGG
TTGGGAAATTGCTAAAGCGTGGGCTGCGGCAACGGGTGGCCATCGTGCGGGCTGTTTAGCTTCTTCTTTTGTGGCGGAAG
TGAAATCCGATTTGATGGGTGAGCAAACCATTCTCTGCGGTATGCTGCAAGCGGGCTCTATCGTTTGTTACGAGAAAATG
GTTGCTGATGGCATCGACCCTGGTTATGCGGGCAAGCTTTTGCAATTTGGTTGGGAAACCATTACCGAAGCACTCAAGTT
TGGCGGTATTACTCATATGATGGATCGCCTGTCTAACCCTGCAAAAATCAAAGCGTTTGAGCTGTCTGAAGAGTTGAAAG
ATCTGATGCGCCCACTGTACAACAAGCATATGGATGACATCATTTCTGGCCACTTCTCTAGCACCATGATGGCGGATTGG
GCGAATGATGATAAAGACTTATTCGGCTGGCGTGCAGAAACCGCTGAGACGGCCTTTGAAAACTATCCAACAACCGACGT
AAAAATTGCTGAGCAAGAATACTTTGATAACGGTATTTTGATGATTGCCATGGTGCGTGCTGGGGTTGAGTTGGCGTTTG
AAGCGATGACGGCTTCAGGCATCATCGATGAGTCGGCTTACTATGAATCACTGCACGAACTCCCACTGATTGCCAATACG
GTAGCGCGTAAGCGTCTGTATGAAATGAACGTGGTAATCTCTGACACTGCTGAGTACGGTAACTATCTGTTTGCCAATGT
GGCGGTACCACTATTGCGTGAAAAGTTTATGCCGAAAGTGGGCACTGATGTGATTGGTAAAGGATTAGGCGTGGTCTCTA
ATCAAGTTGATAACGCAACGCTTATCGAAGTAAACAGCATCATCCGTAACCATCCGGTTGAGTATATCGGTGAAGAGCTG
CGCGGTTACATGAAAGACATGAAGCGCATCGCCGTGGGTGATTAA

Upstream 100 bases:

>100_bases
GTGAATATATCACTTTGCGCAATTTTGTCTCTGGCTTAGTATGAGTTTATTCGGTCAGATCGCACCGACTTAACGGAATC
ACTTATTAAGGAGCACCCTC

Downstream 100 bases:

>100_bases
TCCCTAAATTGATTTCCAAAGCAAACACAACAACACACTATAATAAAAACCAAGAAGGCTTAGTCGAATGACTAAGCCTT
TCTTTATTGAGTGCTAAGTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFK
NAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
VADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEEL
RGYMKDMKRIAVGD

Sequences:

>Translated_494_residues
MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFK
NAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
VADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEEL
RGYMKDMKRIAVGD
>Mature_493_residues
ANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKN
AKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMV
ADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWA
NDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTV
ARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEELR
GYMKDMKRIAVGD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=75.609756097561, Blast_Score=755, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=286, Percent_Identity=29.7202797202797, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_VIBC3 (A5F449)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F449
- SMR:   A5F449
- STRING:   A5F449
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A2550
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- ProtClustDB:   PRK05225
- BioCyc:   VCHO345073:VC0395_A2550-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54613; Mature: 54482

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMP
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCCEEEHHHHHCCCCHH
MIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEEL
CEEHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHCCCCCEEEEEHHHHHHHCCHHHHHHHH
RGYMKDMKRIAVGD
HHHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMP
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCCEEEHHHHHCCCCHH
MIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEEL
CEEHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHCCCCCEEEEEHHHHHHHCCHHHHHHHH
RGYMKDMKRIAVGD
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA