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The map label for this gene is xerC

Identifier: 227080364

GI number: 227080364

Start: 121970

End: 122905

Strand: Direct

Name: xerC

Synonym: VCM66_0128

Alternate gene names: 227080364

Gene position: 121970-122905 (Clockwise)

Preceding gene: 227080363

Following gene: 227080365

Centisome position: 4.22

GC content: 51.82

Gene sequence:

>936_bases
ATGAAGAACGACGAACGCACCCCGCTTCCTGATGCGTTGGCTCAACCGCTGGAGCGTTTTTACGCCTACCTGCATACGGA
AAAAGGGTTGAGCCTGTATACCCAGCGCAATTATAAGCAGCAGTTGGAAACCATGACCCAGTACTTAGTACAGGTTGGGC
TCACCCACTGGACACAGCTTGATTCGGCGTGGGTGCGTCAATTGGTGATGCAGGGGAAAAGGCAGGGGATGAAAGCCAGC
AGTATCGCGACGCGTTTGTCTTCATTGCGCAGTTTCCTGGATTTTCTGATTTTACGTGGCGAGCTTCAGGCTAACCCTGC
GAAAGGCGTCTCTGCGCCGCGCAAGCAGCGTACTTTACCGAAAAATCTCGATGTTGATGAAATGGCGCAGTTACTGGAAG
TGACCGATGATGATCCGCTTTCGATTCGCGATCGGGCGATCATGGAGCTGATGTACGGCGCGGGTTTACGTTTGGCTGAG
CTAGTTTCGATTGATATCAAAGACGTTAATCTAAGCGAAGGTGAGATCCGCGTCATCGGTAAAGGCAACAAAGAGCGCAA
AGTGTGGTTTGCTGGACAGGCACAAGAGTGGGTCGGTAAATGGCTCAAATTGCGCAGTCAATTGGCGGATAGCGCAGAAA
CGGCGCTGTTTGTGTCCAAACTCGGTACCCGTATTTCACACCGTAGTGTGCAAAAACGCATGGCCGAATGGGGCCAAAAA
CAGGCGGTTGCCAGTCATATCAGCCCACATAAATTGCGCCACTCGTTTGCCACCCATATGCTGGAATCGAGCAATAACCT
GCGTGCGGTGCAGGAGCTACTTGGGCACGAGAACATCGCGACAACGCAAATCTATACCCACCTCGATTTTCAACATCTGG
CTCAGGTGTATGACCAAGCGCATCCTCGGGCGCGCAAAAAGAATAAGGATGACTAA

Upstream 100 bases:

>100_bases
GATGGCGGCCACTTTCAGCCGAGTATGGATACCTTGTTTTTGCGCCATCTGGCGTTAGTCTTAGCTCATCTGATCGAGAC
ATTACCTTGGCAGTCACACG

Downstream 100 bases:

>100_bases
CCATGCTGTTTTACCGCCCATTGGCTTCGATTCAAGCACTGACGTTTGATTTGGACGATACCCTTTACGATAACCGTCCG
GTCATCAAACAGGTCGAGGA

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKNDERTPLPDALAQPLERFYAYLHTEKGLSLYTQRNYKQQLETMTQYLVQVGLTHWTQLDSAWVRQLVMQGKRQGMKAS
SIATRLSSLRSFLDFLILRGELQANPAKGVSAPRKQRTLPKNLDVDEMAQLLEVTDDDPLSIRDRAIMELMYGAGLRLAE
LVSIDIKDVNLSEGEIRVIGKGNKERKVWFAGQAQEWVGKWLKLRSQLADSAETALFVSKLGTRISHRSVQKRMAEWGQK
QAVASHISPHKLRHSFATHMLESSNNLRAVQELLGHENIATTQIYTHLDFQHLAQVYDQAHPRARKKNKDD

Sequences:

>Translated_311_residues
MKNDERTPLPDALAQPLERFYAYLHTEKGLSLYTQRNYKQQLETMTQYLVQVGLTHWTQLDSAWVRQLVMQGKRQGMKAS
SIATRLSSLRSFLDFLILRGELQANPAKGVSAPRKQRTLPKNLDVDEMAQLLEVTDDDPLSIRDRAIMELMYGAGLRLAE
LVSIDIKDVNLSEGEIRVIGKGNKERKVWFAGQAQEWVGKWLKLRSQLADSAETALFVSKLGTRISHRSVQKRMAEWGQK
QAVASHISPHKLRHSFATHMLESSNNLRAVQELLGHENIATTQIYTHLDFQHLAQVYDQAHPRARKKNKDD
>Mature_311_residues
MKNDERTPLPDALAQPLERFYAYLHTEKGLSLYTQRNYKQQLETMTQYLVQVGLTHWTQLDSAWVRQLVMQGKRQGMKAS
SIATRLSSLRSFLDFLILRGELQANPAKGVSAPRKQRTLPKNLDVDEMAQLLEVTDDDPLSIRDRAIMELMYGAGLRLAE
LVSIDIKDVNLSEGEIRVIGKGNKERKVWFAGQAQEWVGKWLKLRSQLADSAETALFVSKLGTRISHRSVQKRMAEWGQK
QAVASHISPHKLRHSFATHMLESSNNLRAVQELLGHENIATTQIYTHLDFQHLAQVYDQAHPRARKKNKDD

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4973

COG function: function code L; Site-specific recombinase XerC

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=290, Percent_Identity=57.5862068965517, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1789261, Length=292, Percent_Identity=35.958904109589, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790768, Length=175, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790767, Length=196, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_VIBC3 (A5F4I4)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F4I4
- SMR:   A5F4I4
- STRING:   A5F4I4
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A2391
- eggNOG:   COG4973
- HOGENOM:   HBG727654
- OMA:   HAQGLGP
- ProtClustDB:   PRK00236
- BioCyc:   VCHO345073:VC0395_A2391-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 35550; Mature: 35550

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: ACT_SITE 157-157 ACT_SITE 181-181 ACT_SITE 250-250 ACT_SITE 253-253 ACT_SITE 276-276 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDERTPLPDALAQPLERFYAYLHTEKGLSLYTQRNYKQQLETMTQYLVQVGLTHWTQL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSAWVRQLVMQGKRQGMKASSIATRLSSLRSFLDFLILRGELQANPAKGVSAPRKQRTLP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
KNLDVDEMAQLLEVTDDDPLSIRDRAIMELMYGAGLRLAELVSIDIKDVNLSEGEIRVIG
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEE
KGNKERKVWFAGQAQEWVGKWLKLRSQLADSAETALFVSKLGTRISHRSVQKRMAEWGQK
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVASHISPHKLRHSFATHMLESSNNLRAVQELLGHENIATTQIYTHLDFQHLAQVYDQA
HHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHH
HPRARKKNKDD
CCHHHCCCCCC
>Mature Secondary Structure
MKNDERTPLPDALAQPLERFYAYLHTEKGLSLYTQRNYKQQLETMTQYLVQVGLTHWTQL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSAWVRQLVMQGKRQGMKASSIATRLSSLRSFLDFLILRGELQANPAKGVSAPRKQRTLP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
KNLDVDEMAQLLEVTDDDPLSIRDRAIMELMYGAGLRLAELVSIDIKDVNLSEGEIRVIG
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEE
KGNKERKVWFAGQAQEWVGKWLKLRSQLADSAETALFVSKLGTRISHRSVQKRMAEWGQK
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVASHISPHKLRHSFATHMLESSNNLRAVQELLGHENIATTQIYTHLDFQHLAQVYDQA
HHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHH
HPRARKKNKDD
CCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA