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The map label for this gene is opuE [H]

Identifier: 226951038

GI number: 226951038

Start: 4096975

End: 4098348

Strand: Direct

Name: opuE [H]

Synonym: CLM_4077

Alternate gene names: 226951038

Gene position: 4096975-4098348 (Clockwise)

Preceding gene: 226951037

Following gene: 226951039

Centisome position: 98.6

GC content: 29.18

Gene sequence:

>1374_bases
TTGCTTATAGTAAGTATAATTTTAACATTAATTTTAACTGGAGTCGCTGGATATATTGGAAAACTAAAAGTAAAAACAGC
CAAGGACTTTATAAATGCAGACAATAAATTAGGTATATTAGGAGTAACTAGCATGCTTATGGGCTCTATAATAGGTGGTG
CTTCCACTGTAGGTACTGCACAAATGGCTTATAAACATGGGATATCTGCTATATGGTTTATATTAGGTTTGTGTATTTCT
AGTATTTTATTAGGACTCATATATTCAAACCAAGTTGGTAAGGACAGTATGACTACTCTACCTCAAATTATAGGAAACAC
TTATGGATTAAAAGCAAGAACTAGCTCTAGCTTATTATTATCTTTAGGTATGTTTATTCATATAAGTGGCCAAGTATTAG
CCTGCACTCCTCTTTTTACATCTATATTTAACATAGATGTAAAAATAACTTCTATAATAGTAATTTTTTTATTAGTTTTT
TATATAATTTTCGGAGGTTTTTGGGGAAGTACTATGGTAGGTGCTGTTAAAACCATACTTTTATATGGTACAAGTATAAT
ATGCGGATTTATATTAATATTTTCACTAAATGGAACTGCAGAAATTTTTAATTATTTTCCTAAAAATCCTTGGTTCAATA
TATTTAGTGATGGTATTTTTCAAGATTTAGCCTTAGGATTTTCTACAGTACTTGGAATACTATCTACTCAGACTTACTTT
CAATCTATTATGGCTGGTAAAAACCCAAAAACTTCTAAAATAAGTTCTTTTTTAGTAGCCTTTTTAATATTTCCAGTAGG
TATTGTATGTACATTTATAGGAATGTACATGAAAATTCACTTTCCAAACATAAACCCTAATGAAGCTTTTCCTCTGTTTT
TAATTAATTACCTTCACCCAATTTTAGGTGGAGTATCTATAGCTACAGTGCTTATATCTTCCATAGCTACTGGAGCTGGA
TTAGCTTTGGGTATAGCTACCATGATGGTAAAAGATATTATACCAACTTTATCTAATAAAAAATTAGAGGATAAAAAAGA
AATTTTATATTTAAGAATATGTATTCTAATAATAGGTGTCTTAACCTTAATTATAGTTATAAATAACACCGATTCCATGA
TATTAGATTGGGGATTCTTATCTATGATATTTAGAGCTACACCTATTTTTATACCGGCATTATGTGCACTATTTTTTAAA
AGCAAGATTAATAGCAAAGCAGGATTTTACTCTATATTAGCTGGTCCACTATCAAGTATTTTGTGGATAATCATTGGATT
TAGCCAAATAACCTCTATATATATAGGTATTACCATGAATATACTTGCTATGGCTGCAGCAAGTAAGAAGTTTAATTCTA
TGGAAAAAATATAA

Upstream 100 bases:

>100_bases
AATTAACTCATATTTAGTGTATTATTAGATTTGAAATAAAAACATATATATCTTTTATTGCTATAATAATATTATTAGGC
ATTAAAAAGGGGATGGGACA

Downstream 100 bases:

>100_bases
ATCTTCTTTTCTGCTGTATTAAAAAACCTCTTTTGATTAAAGATAATACTATATTAATTAAAGGAGGTTTAGTATGGCTA
AAAAAGGAATGAAAAGACCA

Product: sodium:solute symporter family protein

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLIVSIILTLILTGVAGYIGKLKVKTAKDFINADNKLGILGVTSMLMGSIIGGASTVGTAQMAYKHGISAIWFILGLCIS
SILLGLIYSNQVGKDSMTTLPQIIGNTYGLKARTSSSLLLSLGMFIHISGQVLACTPLFTSIFNIDVKITSIIVIFLLVF
YIIFGGFWGSTMVGAVKTILLYGTSIICGFILIFSLNGTAEIFNYFPKNPWFNIFSDGIFQDLALGFSTVLGILSTQTYF
QSIMAGKNPKTSKISSFLVAFLIFPVGIVCTFIGMYMKIHFPNINPNEAFPLFLINYLHPILGGVSIATVLISSIATGAG
LALGIATMMVKDIIPTLSNKKLEDKKEILYLRICILIIGVLTLIIVINNTDSMILDWGFLSMIFRATPIFIPALCALFFK
SKINSKAGFYSILAGPLSSILWIIIGFSQITSIYIGITMNILAMAAASKKFNSMEKI

Sequences:

>Translated_457_residues
MLIVSIILTLILTGVAGYIGKLKVKTAKDFINADNKLGILGVTSMLMGSIIGGASTVGTAQMAYKHGISAIWFILGLCIS
SILLGLIYSNQVGKDSMTTLPQIIGNTYGLKARTSSSLLLSLGMFIHISGQVLACTPLFTSIFNIDVKITSIIVIFLLVF
YIIFGGFWGSTMVGAVKTILLYGTSIICGFILIFSLNGTAEIFNYFPKNPWFNIFSDGIFQDLALGFSTVLGILSTQTYF
QSIMAGKNPKTSKISSFLVAFLIFPVGIVCTFIGMYMKIHFPNINPNEAFPLFLINYLHPILGGVSIATVLISSIATGAG
LALGIATMMVKDIIPTLSNKKLEDKKEILYLRICILIIGVLTLIIVINNTDSMILDWGFLSMIFRATPIFIPALCALFFK
SKINSKAGFYSILAGPLSSILWIIIGFSQITSIYIGITMNILAMAAASKKFNSMEKI
>Mature_457_residues
MLIVSIILTLILTGVAGYIGKLKVKTAKDFINADNKLGILGVTSMLMGSIIGGASTVGTAQMAYKHGISAIWFILGLCIS
SILLGLIYSNQVGKDSMTTLPQIIGNTYGLKARTSSSLLLSLGMFIHISGQVLACTPLFTSIFNIDVKITSIIVIFLLVF
YIIFGGFWGSTMVGAVKTILLYGTSIICGFILIFSLNGTAEIFNYFPKNPWFNIFSDGIFQDLALGFSTVLGILSTQTYF
QSIMAGKNPKTSKISSFLVAFLIFPVGIVCTFIGMYMKIHFPNINPNEAFPLFLINYLHPILGGVSIATVLISSIATGAG
LALGIATMMVKDIIPTLSNKKLEDKKEILYLRICILIIGVLTLIIVINNTDSMILDWGFLSMIFRATPIFIPALCALFFK
SKINSKAGFYSILAGPLSSILWIIIGFSQITSIYIGITMNILAMAAASKKFNSMEKI

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 49487; Mature: 49487

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVSIILTLILTGVAGYIGKLKVKTAKDFINADNKLGILGVTSMLMGSIIGGASTVGTA
CHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHHHHHH
QMAYKHGISAIWFILGLCISSILLGLIYSNQVGKDSMTTLPQIIGNTYGLKARTSSSLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
SLGMFIHISGQVLACTPLFTSIFNIDVKITSIIVIFLLVFYIIFGGFWGSTMVGAVKTIL
HHHHHHEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGTSIICGFILIFSLNGTAEIFNYFPKNPWFNIFSDGIFQDLALGFSTVLGILSTQTYF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSIMAGKNPKTSKISSFLVAFLIFPVGIVCTFIGMYMKIHFPNINPNEAFPLFLINYLHP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
ILGGVSIATVLISSIATGAGLALGIATMMVKDIIPTLSNKKLEDKKEILYLRICILIIGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LTLIIVINNTDSMILDWGFLSMIFRATPIFIPALCALFFKSKINSKAGFYSILAGPLSSI
HHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LWIIIGFSQITSIYIGITMNILAMAAASKKFNSMEKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIVSIILTLILTGVAGYIGKLKVKTAKDFINADNKLGILGVTSMLMGSIIGGASTVGTA
CHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHHHHHH
QMAYKHGISAIWFILGLCISSILLGLIYSNQVGKDSMTTLPQIIGNTYGLKARTSSSLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
SLGMFIHISGQVLACTPLFTSIFNIDVKITSIIVIFLLVFYIIFGGFWGSTMVGAVKTIL
HHHHHHEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGTSIICGFILIFSLNGTAEIFNYFPKNPWFNIFSDGIFQDLALGFSTVLGILSTQTYF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSIMAGKNPKTSKISSFLVAFLIFPVGIVCTFIGMYMKIHFPNINPNEAFPLFLINYLHP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
ILGGVSIATVLISSIATGAGLALGIATMMVKDIIPTLSNKKLEDKKEILYLRICILIIGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LTLIIVINNTDSMILDWGFLSMIFRATPIFIPALCALFFKSKINSKAGFYSILAGPLSSI
HHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LWIIIGFSQITSIYIGITMNILAMAAASKKFNSMEKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]