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The map label for this gene is ttcA [H]

Identifier: 226950722

GI number: 226950722

Start: 3749295

End: 3750044

Strand: Direct

Name: ttcA [H]

Synonym: CLM_3731

Alternate gene names: 226950722

Gene position: 3749295-3750044 (Clockwise)

Preceding gene: 226950708

Following gene: 226950725

Centisome position: 90.23

GC content: 27.2

Gene sequence:

>750_bases
TTGATTATATTTGAAAAAAACTACAATAAAATATTTTTAAAGTATGTAAGAAGAGCTATAGATGACTATAATATGATATC
CCCAAGAGACAAAATCGCTGTAGCTGTTTCTGGTGGTAAAGATAGCATCTTCTTGTTATTTTGTTTAAAGCTAATACAAT
TAACAGCTATAAAAGATATTGAAATAGTAGCTATTCATGTAGACTTAGGCCTAGATATGGATCTAGAACCATTAAAATTT
TTTTGCAAGAAAAATAGCATAGACTTAGTAATAGAAAAAACCAATATTGCAAATGTAGTATTCAATGAAAGAAAAGAAAA
AAATCCATGTTCCCTTTGTTCTAAACTAAGAAAAGGTTGCCTTGTAAGAGTTTCTAAATCCATAGGTGCCACAAAAATAG
CTCTTGGGCATAATTGTGATGATGTAATAGAAACTTTATTTATGAATGTTTTAAAAATTGGTAAGTTTGGATCTTTTAAT
CCCCATATAGATTACAAAGATAAATATGTACATATAATCAGACCTTTAATATATTTAAGAGAAGATCTTATTAAAGATTT
GGTAAAAAAACACAATTTACCTGTGGTTAAAAGTACTTGTCCTGAGGATAAAAAGACTACTAGAGAAGAAATGAAAAATT
TAATGTTTAAGCTAGAAGAAACTTACCCTAAAGCTATAGATAGACTTATGACCTCTCTATGTAATATAGATATGAAAAAT
CTTTGGAAACAAAGAGATAATCATTTTTAA

Upstream 100 bases:

>100_bases
TGAAAATCTATTTAATATTATTATAAAATCTATTTATATCTACTATTTAGTATTGTAAATTATATATGTTTTTATGTAAA
TTGAGAAAGGGGTTATTTTA

Downstream 100 bases:

>100_bases
TAATAAAAATGATATCATATTAACTACAAAAATAAAAATAAGAAACTCTATATAAAGAGTCTCTTATTTTTATTTTCATT
AATACATTCCATCCATTCCC

Product: PP-loop family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLDMDLEPLKF
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFN
PHIDYKDKYVHIIRPLIYLREDLIKDLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNHF

Sequences:

>Translated_249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLDMDLEPLKF
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFN
PHIDYKDKYVHIIRPLIYLREDLIKDLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNHF
>Mature_249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLDMDLEPLKF
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFN
PHIDYKDKYVHIIRPLIYLREDLIKDLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNHF

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=238, Percent_Identity=32.7731092436975, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193211090, Length=227, Percent_Identity=29.5154185022026, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17540090, Length=243, Percent_Identity=24.2798353909465, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651972, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28902; Mature: 28902

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDI
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCE
EIVAIHVDLGLDMDLEPLKFFCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGC
EEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFNPHIDYKDKYVHIIRPLIYLR
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDLIKDLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LWKQRDNHF
HHHHHCCCC
>Mature Secondary Structure
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDI
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCE
EIVAIHVDLGLDMDLEPLKFFCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGC
EEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFNPHIDYKDKYVHIIRPLIYLR
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDLIKDLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LWKQRDNHF
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA