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The map label for this gene is mutS2 [H]

Identifier: 226950552

GI number: 226950552

Start: 3561066

End: 3563432

Strand: Reverse

Name: mutS2 [H]

Synonym: CLM_3528

Alternate gene names: 226950552

Gene position: 3563432-3561066 (Counterclockwise)

Preceding gene: 226950553

Following gene: 226950551

Centisome position: 85.76

GC content: 30.5

Gene sequence:

>2367_bases
GTGAAGGATAAATCTATTAAGGTTTTAGAATTTAATAAAATACAGGAAATTTTAAAAAATTACACCTGTACAAAAGCTGC
AAAAGATATAATAGAAGATTTAAAACCTTATGATAGTATGTATGAAGTAAGGGAGCACTTAGAAGAAACAAAGGAAGCCT
TTAAATTATTGATTACAAAGGGAGCACCACCCTTTGAAGGGGTATACGATATAAGAAGTGGAATTTCCTTAGCAGAAAAA
GGATCTGCATTATTGCCAGGGCAACTTTTAAAAATAGCTGCAGTTTTAAGGTGTGCAAGAAGATTCAAAGAATATATAAA
TCATAAGGAAGAGGAAGAAAGCTATAGGGTTTTAGAGAATATATGTGAGGGTATTTTCTCATTGCCTAAAATAGAAGAAG
AGATATTTAATGCTATAGAAGGAGAAGATGAAATAGCAGATAGAGCCAGTTCTACTCTTTATAACATAAGAAGATCTTTA
AAAGAAAAAAATTATTCTGTAAGAGATAAAATAAACTCTTTAGTTAGAAGTTATTCCTCTTATCTTCAAGAAAATATATA
TACAGTTAGAGGAGATAGATATGTTTTACCAGTAAAGGCAGAACATAAGGGAGCAGTACCAGGACTTGTGCATGATCAAA
GTTCTACAGGGGCTACTCTTTTTATAGAACCTATGAGTTTAGTTAACTTAAATAATGAAATAAAAGAGCTTATGTTAAAA
GAAAAGGCGGAAATAGAAAGAATATTAACTGTTCTATCAGCTAAAATAAATGCTAATATAACTGGAGTAAAGACAGATGC
TAATATAGTATGGGAATTAGATTTTATATTTGCTAAAGCGAAATTTGCTAGTGAATATAATTGCACTTGTCCAACTATTA
ATGATGAAGGTATCGTTGATATTATAGAAGGAAGGCATCCTCTTATAGATAGAAGAGAGGTAGTCCCTATAAGTGTTAAG
TTAGGAGAAGAGTTTACATCCTTAATGATAACAGGACCTAATACAGGAGGTAAAACTGTAACTTTAAAAACAGTAGGGTT
AATACATTTAATGGCTATGAGTGGACTTATGATTCCTGCTAGAGAAAACTCTGTAATAAGTTATTTTAATAATGTTTTTG
CAGATATAGGAGATGAGCAAAGTATAGAGCAAAGTTTATCCACTTTTTCATCTCATATGAAAAATATAGTAGAAATTATG
GATAAAGCAGATGAGAACTCTTTAGTTTTATTTGATGAATTAGGAGCAGGAACAGATCCAACAGAAGGAGCAGCGTTAGC
TATTTCTATATTAGAAAACTTAAGAAAAAGAGGAACAAAGATAATTGCTACAACTCATTATAGTGAACTAAAAGCTTATG
CTTTAAGAAAAGAAGGGGTAGAAAATGCTTCTGTTGAGTTTGATGTGGAAACTTTAAGACCTACTTATAGATTATTAATA
GGCATACCCGGTAAATCAAATGCCTTTGAAATATCTAAAAGATTAGGATTGCCAGATTATATTATAGATTTTGCTAGAGA
AAATATATCTAATGAAAATATAAGATTTGAGGAATTAATTGAGAACTTGCAAGAAAAGAGTATAAAGGCTGAAGAGGATG
CAAGACTTGCAGAAAATCTTAAATTGGAAAGAGATAAAGAAAAGAAAAAATACGAAGAAAAATTAGAAGGACTTCAAAAA
GTTAGAGATAATGCTTTGATAGATGCAAGAAGGGAAGCAAAGAATATAATAAAAGAAGCAAAAGAAGAGGCAGATAAAAT
ATTAAAAGATATAAGACAATTAGAAAGAATGGGTTATTCTTCAGATGCAAGGCGTAAATTAGAAGAGGAAAGAAAAAAAT
TAAAAGATAAATTAGATTCTATTGAAGAAAAGGAAATTAAAACAGTTCATGAAGGAGAAGCTTTAAAGAATGTAAAAGAA
GGAGATGAAGTTCTTTTAGCTTCAATAAACCAAAAGGTAATAGTTCTATCAAAACCAGACAATAAAGGTGATGTATTAGT
TCAAGCCGGAATTATGAAAATAACAGCTAATATTAAAGATTTAAGAGCTGCTAAGGGAAGTAATTCTAATAATAGTTCAT
CAAAAATAAAGAAATCCAAAAAACTCAATTTGAATTTAAGGAGAGTAGAGTCTTCTGTGGATCTTAGAGGAATGGATGCA
GAAGAAGCTATATATACTGTAGATAAATATTTAGATGAGGCTTATTTAGGTGGCTTGGGAGAAGTTACTATAGTACATGG
TAAAGGTACAGGAGTTTTAAGAAAAACAATTATGGATATGCTAAAAGGTCATTCTCATGTTAAGAAATATAGACTAGGTG
AATATGGTGAAGGTGGTACTGGAGTTACAGTAGTAGAGCTAAAGTAG

Upstream 100 bases:

>100_bases
TGGGTATATAGCAGTTATAATTAAGCTGAGAATAGATAGGATTAAAAAATAATAGAAAAAGTAACAGAAACCCAGAAAAG
TTAAAAGGAGTGTTAAAGAA

Downstream 100 bases:

>100_bases
ATTTAAATTAGATAGCTTAGGTTTAGACGAACTTTTTACTAAAATCTAAGCTATTAATTTATTCATAATGTAGAGGAGTT
TAAAGTTTAGAATTAGAGAA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITKGAPPFEGVYDIRSGISLAEK
GSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLENICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSL
KEKNYSVRDKINSLVRSYSSYLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLK
EKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVDIIEGRHPLIDRREVVPISVK
LGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPARENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIM
DKADENSLVLFDELGAGTDPTEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLI
GIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAEEDARLAENLKLERDKEKKKYEEKLEGLQK
VRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYSSDARRKLEEERKKLKDKLDSIEEKEIKTVHEGEALKNVKE
GDEVLLASINQKVIVLSKPDNKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDA
EEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGTGVTVVELK

Sequences:

>Translated_788_residues
MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITKGAPPFEGVYDIRSGISLAEK
GSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLENICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSL
KEKNYSVRDKINSLVRSYSSYLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLK
EKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVDIIEGRHPLIDRREVVPISVK
LGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPARENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIM
DKADENSLVLFDELGAGTDPTEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLI
GIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAEEDARLAENLKLERDKEKKKYEEKLEGLQK
VRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYSSDARRKLEEERKKLKDKLDSIEEKEIKTVHEGEALKNVKE
GDEVLLASINQKVIVLSKPDNKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDA
EEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGTGVTVVELK
>Mature_788_residues
MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITKGAPPFEGVYDIRSGISLAEK
GSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLENICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSL
KEKNYSVRDKINSLVRSYSSYLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLK
EKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVDIIEGRHPLIDRREVVPISVK
LGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPARENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIM
DKADENSLVLFDELGAGTDPTEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLI
GIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAEEDARLAENLKLERDKEKKKYEEKLEGLQK
VRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYSSDARRKLEEERKKLKDKLDSIEEKEIKTVHEGEALKNVKE
GDEVLLASINQKVIVLSKPDNKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDA
EEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGTGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=301, Percent_Identity=30.8970099667774, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI26638666, Length=246, Percent_Identity=32.9268292682927, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI4505253, Length=246, Percent_Identity=32.9268292682927, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI26638664, Length=247, Percent_Identity=32.7935222672065, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI36949366, Length=456, Percent_Identity=25.6578947368421, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI262231786, Length=195, Percent_Identity=34.8717948717949, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4557761, Length=182, Percent_Identity=31.3186813186813, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4504191, Length=220, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789089, Length=259, Percent_Identity=31.6602316602317, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17534743, Length=389, Percent_Identity=23.6503856041131, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=290, Percent_Identity=25.8620689655172, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17539736, Length=286, Percent_Identity=23.7762237762238, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508447, Length=287, Percent_Identity=27.1777003484321, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=321, Percent_Identity=28.0373831775701, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=329, Percent_Identity=23.7082066869301, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321109, Length=284, Percent_Identity=25.7042253521127, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319935, Length=310, Percent_Identity=28.0645161290323, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320047, Length=188, Percent_Identity=32.4468085106383, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=271, Percent_Identity=26.9372693726937, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664545, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24584320, Length=250, Percent_Identity=31.6, Blast_Score=98, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88649; Mature: 88649

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITK
CCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GAPPFEGVYDIRSGISLAEKGSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLEN
CCCCCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSLKEKNYSVRDKINSLVRSYSS
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLK
HHHHCCEEECCCEEEEEEECCCCCCCCCCEECCCCCCCEEEECCHHHHCCCHHHHHHHHH
EKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVD
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEE
IIEGRHPLIDRREVVPISVKLGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPA
EECCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCCCC
RENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIMDKADENSLVLFDELGAGTDP
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLI
CCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEHHHHCCEEEEEE
GIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAEEDARLAENL
ECCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
KLERDKEKKKYEEKLEGLQKVRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDARRKLEEERKKLKDKLDSIEEKEIKTVHEGEALKNVKEGDEVLLASINQKVIVLSKPD
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCHHHHEECCCEEEEEECCC
NKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDA
CCCCEEEEECHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCH
EEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGT
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCC
GVTVVELK
CEEEEEEC
>Mature Secondary Structure
MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITK
CCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GAPPFEGVYDIRSGISLAEKGSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLEN
CCCCCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSLKEKNYSVRDKINSLVRSYSS
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLK
HHHHCCEEECCCEEEEEEECCCCCCCCCCEECCCCCCCEEEECCHHHHCCCHHHHHHHHH
EKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVD
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEE
IIEGRHPLIDRREVVPISVKLGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPA
EECCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCCCC
RENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIMDKADENSLVLFDELGAGTDP
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLI
CCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEHHHHCCEEEEEE
GIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAEEDARLAENL
ECCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
KLERDKEKKKYEEKLEGLQKVRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDARRKLEEERKKLKDKLDSIEEKEIKTVHEGEALKNVKEGDEVLLASINQKVIVLSKPD
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCHHHHEECCCEEEEEECCC
NKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDA
CCCCEEEEECHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCH
EEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGT
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCC
GVTVVELK
CEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA