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The map label for this gene is lpxD [C]

Identifier: 226950536

GI number: 226950536

Start: 3534908

End: 3535654

Strand: Reverse

Name: lpxD [C]

Synonym: CLM_3512

Alternate gene names: 226950536

Gene position: 3535654-3534908 (Counterclockwise)

Preceding gene: 226950537

Following gene: 226950535

Centisome position: 85.09

GC content: 30.52

Gene sequence:

>747_bases
ATGAAAATGAATTATATATCCCCGAAATCTAAATTAGGCAATAACGTTGAAATAGGAAGATTTGCTGTTATAGAAGATAA
TGTAGTTATAGGAGAAAATTGTATTATAGGGCATAATGTAATTATACATAAAGGAACAATCATAGGTAATAATGTAAGAA
TAGATGATAATACTGTAATAGGAAAAGAACCCATGAGGTCAGTAAACAGTATATTTAAAGATGATAAAGAGTTTGAACCA
TGTAAAATTAATGATGAATGTTTAATAGGAGCAGGTGTAATAGTATATATAGGTTCTAAAATAGGTAATAAAACTTTAGT
AGCTGACCTAGCTGTTATAAGAGAAGACGTAACTATAGGAGAAAGAACAATAATAGGCAAAGGTGCAACTATAGAAAACT
TTTGCAAAGTGGGCTCAAATTGCAAAATTCAGACTAATGTATATTTAACAGCATATTCAGAAGTAGAGGATTATGTTTTC
ATAGCACCTTGTGTAGTAACATCTAATGATAACTATGCTGCTCGATCAAAAGAAAGATTTGGTAAATTTAAAGGTGTTAC
AATTAAAAAAGGTGGAAGAATAGGGGCAGGTGCAGTTATATTGCCAGGAAAAATAATATATGAAGATGGATTTGCAGCAG
CAGGAAGTTTAGTAACTAGGGATATAGAAAAAGCTAAGATAGTTGCAGGAGTACCAGCTAAAATATTTAATGATGTACCA
AAAGAACAGTTGTTAGAAAATCAATAG

Upstream 100 bases:

>100_bases
ATTTATTAAATAAAAATTAAATTTTTAAAATTACCATCAAAATATGATATTATATTATGGTGGTAATTTTAAAATTTTAT
TTTAATATAGGAGTGAAAAC

Downstream 100 bases:

>100_bases
CTAAAAATAAGGATTAAAGGGTGTTTTAAGTTGAGTTATAAGAGGAATATTGCAAGTAATTTTTTAACACAAATAATAGC
ATCAGCTATAGGCTTTTTTA

Product: putative acetyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: Hexapaptide Repeat-Containing Transferase; Transferase Hexapeptide Repeat Containing Protein; Acetyl/Acyl Transferase Related Protein; WxcM-Like Protein; Transferase Hexapeptide Repeat; Hexapeptide Repeat-Containing Transferase; Acetyltransferases; Acetyl / Acyl Transferase Related Protein; Acyltransferase; Bacterial Transferase Hexapeptide Repeat Protein; UDP-N-Acetylglucosamine Acyltransferase; Acetyltransferase Protein; UDP-3-O-[3-Hydroxymyristoyl] Glucosamine N-Acyltransferase; WblC Protein; Isoleucine Patch Superfamily Acetyltransferase; CysE Serine O-Acetyltransferase; Oxidoreductase Domain Protein; UDP-3-O-(3-Hydroxymyristoyl)-Like Protein; Carbonic Anhydrase/Acetyltransferase; Transferase Protein; WxcM Domain-Containing Protein; Hexapeptide Transferase; Carbohydrate Kinase Rmoresistant Glucokinase; Hexapeptide Transferase Family Protein; WbbJ Protein; WxcM-Like; 3-Hydroxymyristoyl; AChain A; Acetyl/Acyl Transferase-Like Protein; Carbonic Anhydrases/Acetyltransferases

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKMNYISPKSKLGNNVEIGRFAVIEDNVVIGENCIIGHNVIIHKGTIIGNNVRIDDNTVIGKEPMRSVNSIFKDDKEFEP
CKINDECLIGAGVIVYIGSKIGNKTLVADLAVIREDVTIGERTIIGKGATIENFCKVGSNCKIQTNVYLTAYSEVEDYVF
IAPCVVTSNDNYAARSKERFGKFKGVTIKKGGRIGAGAVILPGKIIYEDGFAAAGSLVTRDIEKAKIVAGVPAKIFNDVP
KEQLLENQ

Sequences:

>Translated_248_residues
MKMNYISPKSKLGNNVEIGRFAVIEDNVVIGENCIIGHNVIIHKGTIIGNNVRIDDNTVIGKEPMRSVNSIFKDDKEFEP
CKINDECLIGAGVIVYIGSKIGNKTLVADLAVIREDVTIGERTIIGKGATIENFCKVGSNCKIQTNVYLTAYSEVEDYVF
IAPCVVTSNDNYAARSKERFGKFKGVTIKKGGRIGAGAVILPGKIIYEDGFAAAGSLVTRDIEKAKIVAGVPAKIFNDVP
KEQLLENQ
>Mature_248_residues
MKMNYISPKSKLGNNVEIGRFAVIEDNVVIGENCIIGHNVIIHKGTIIGNNVRIDDNTVIGKEPMRSVNSIFKDDKEFEP
CKINDECLIGAGVIVYIGSKIGNKTLVADLAVIREDVTIGERTIIGKGATIENFCKVGSNCKIQTNVYLTAYSEVEDYVF
IAPCVVTSNDNYAARSKERFGKFKGVTIKKGGRIGAGAVILPGKIIYEDGFAAAGSLVTRDIEKAKIVAGVPAKIFNDVP
KEQLLENQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.- [C]

Molecular weight: Translated: 26897; Mature: 26897

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMNYISPKSKLGNNVEIGRFAVIEDNVVIGENCIIGHNVIIHKGTIIGNNVRIDDNTVI
CCCCCCCCHHHCCCCCEEEEEEEEECCEEECCCEEEECEEEEEECEEECCEEEECCCEEE
GKEPMRSVNSIFKDDKEFEPCKINDECLIGAGVIVYIGSKIGNKTLVADLAVIREDVTIG
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCC
ERTIIGKGATIENFCKVGSNCKIQTNVYLTAYSEVEDYVFIAPCVVTSNDNYAARSKERF
CEEEEECCCCHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEEEECCCCCCHHCHHHH
GKFKGVTIKKGGRIGAGAVILPGKIIYEDGFAAAGSLVTRDIEKAKIVAGVPAKIFNDVP
CCCCCEEEECCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHEEEECCCHHHHHCCC
KEQLLENQ
HHHHHCCC
>Mature Secondary Structure
MKMNYISPKSKLGNNVEIGRFAVIEDNVVIGENCIIGHNVIIHKGTIIGNNVRIDDNTVI
CCCCCCCCHHHCCCCCEEEEEEEEECCEEECCCEEEECEEEEEECEEECCEEEECCCEEE
GKEPMRSVNSIFKDDKEFEPCKINDECLIGAGVIVYIGSKIGNKTLVADLAVIREDVTIG
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCC
ERTIIGKGATIENFCKVGSNCKIQTNVYLTAYSEVEDYVFIAPCVVTSNDNYAARSKERF
CEEEEECCCCHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEEEECCCCCCHHCHHHH
GKFKGVTIKKGGRIGAGAVILPGKIIYEDGFAAAGSLVTRDIEKAKIVAGVPAKIFNDVP
CCCCCEEEECCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHEEEECCCHHHHHCCC
KEQLLENQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA