Definition Clostridium botulinum A2 str. Kyoto chromosome, complete genome.
Accession NC_012563
Length 4,155,278

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The map label for this gene is pbpA [H]

Identifier: 226950512

GI number: 226950512

Start: 3508071

End: 3510566

Strand: Direct

Name: pbpA [H]

Synonym: CLM_3488

Alternate gene names: 226950512

Gene position: 3508071-3510566 (Clockwise)

Preceding gene: 226950510

Following gene: 226950519

Centisome position: 84.42

GC content: 30.97

Gene sequence:

>2496_bases
ATGGGAAAAAAGAAAAAAAAGCGCAAATCTAGCGCCTTTAAAATAATACTTAATGTCTTTTTAAGTATTTTCTTAGTAGC
TGGAGTAGCCTTTGGTGGAATTGTGTTTGCGATGATAAAAACAGCTCCTCCACTAAATGTACAGCAAGTTCTCACTTTTG
ATGAGCCCTCTATACTTTATGATGATAAAGGTCAATATATGGATAAAGTTATAACTAACGAACAAAGAATTGTAGTTGAT
TATAAAAATGTACCTCAAAATTTAAAAAATGCATTTGTAAGTATAGAAGATGAAAGATTTTATAAACATCATGGAGTTGA
CATAAAAAGATTTACTGGTGTTATATTAATTAATGTGACTAATAAAATAAAAAGGAGTTCTAAACTTCAGGGAGCTTCTA
CTCTAACTCAACAGTTAATAAAAAATACAGTTTTATCCTCTGAAGTTTCTATTAAAAGAAAAGTTCAGGAAATGTACTTA
TCTATACAACTAGAAAAAGAGATATCGAAGGATGAAATTTTAGGTGCCTATATGAATAGTATATTTTTAGGCGGAAATGC
TTTAGGGGTAGAGGCAGCCTCAAAACAGTATTTTAATAAAAGTGTAAAAGATCTATCTTTAATAGAATGTGCTTTTATTG
CTGGAGTACCTCAAAGTCCATCAGTTTACTATCCCTATTCATCTGTTGCTAAGAAAAACCCTTCTATTTATTTAAATAGA
ACAAAAACTGTTTTATATAAAATGTTAGACAATGGCTATATTACTCAAAATGATTATAATAAAGCTTTAAAGGATTTAGA
TAGTAAAAAGCTAGCCTTTGCTAAACCATCTGCCCCTAACAATAAGTTAGCCTATGAATGGTTCTCTATTCCTGCTATTG
AGCAAGTAAAAAAAGATTTAAAGACTCAATATAAATATGATGACAAACAAATTCATAACCTTTTAGTTAATGGTGGTTTA
AAAATATATACTACTATGAATAAAAATTTACAAGATAAGACTCAAAATACAATAAATGATGCTTATTATTTAAATTCTTA
TAAAAGTAATGGTATGATATATCCTCAAGCCTCTGCTGTAATAATGGACTATCATAATGGTGAGGTAAAAACTATAATTG
GAGGTAGAGGCGACCAACCTGCTAGATCTTATAACAGAGCAGCTTCTTATAACTATCTAAGACCTGCCGGCTCTAGTATT
AAACCTCTTACAGTATATAGTGCTGCTATAGATAGTAAAAAAGCCACTTCTGCTACTGGATTTGAAGATTCTCCAATTCC
AGATAATATAGGACGTAAATATAGTTCTGGAGCACCTTATAATCCTAAAAATAGCCCTAATATTTATTCTGGATATGTAA
ATGTAAGAGAGGCTTTAAAGCGCTCTATAAACGTAATAGCCGTAAAACTTGTAGATAGAATAGGACTCAATACTAGTATA
CAATATGCTGAAAAATTTGGAATTCCTATAGACCAACATGATAGGAGTAGTATTGCATCTCTAGCTTTAGGAGAATTACA
TAAAGGTACTAATCCTTTAATAATGGCTCAGGCCTACGGTGTATTTGGCAATAATGGAACTTATACAGAAGCAAAATTAT
ATACAAAAGTTGTAGACAGATCTGGTAAGGTTATTTTAGAACCTAAAACTAATACAAAAAAGGTTCTTTCACCAGAAGCT
GCTTTTATAACTTACGATATGCTTCAAGGACCTGTAAGTGAAGGAGGTACCGGAACTCAAGCTAATTTTGGTAATATGGA
GGTTAGAGGTAAGACTGGTACATCTAGTGATATGAAAAACTTATGGTTCTGCGGATTAACTCCTTATTATTCCGCAGCGG
TTTGGATAGGTAATGATAATTCTTCTACAGTAGATGGAGTATATAGTAGCACTGCTGCTAGACTTTGGGGAGATATTGTG
AAAGAATTCCATGTTAATCTTCCCTATAAACAAGTTCAAAAACCAGCTAGTGTTATAACTGCTAACGTAGATAGAATTTC
TGGTAAACTTCCAACTCAGCTATCTTATAGAGATCCTAGAGGAAGTACAGTATATAATGAATTTTTTATAAATGGAACTA
TTCCAACAGAATATGATGATATACATGTAGAAGCTCAAATAAATAAGTTAACTGGTAAATTAGCAAGTAAATTTACCCCT
TCATTCCTTGTAGAATCTAGAGTATTCTTAAGAAGAGATTACTCTCCTGGTATAGAACTTTTAGATCAACAATGGGTTCT
CCCTTATTCTATAGATGAAGGAGGAAGCTTACCACCTACTGAAGAAAAAAATAACTCTAATACTAGAGATAAAAATAAAG
ATAAGGATAAGAATAAAAATAAGAATAAAAATAAGAATAAAGATAAGAATCCTTCACAGGATAAACCTAATAATAATGAT
AACAATAGTAACAATAATAACGACAATAACAACAATGCTAAACCTCCTGAAAATGATTCAAATCAAAATCAAGAAGACAA
AAAGAACAAACGATAA

Upstream 100 bases:

>100_bases
ATAATTAGGATTTTTTCTATTTATTCATAAGTAATTCAATATGTGTTATAATATTAAAAATAATGTTTTATTTTACCCTA
ACTAAGGAGGACAAATATAT

Downstream 100 bases:

>100_bases
AAAGAATAAAAACTCCTTTTTGGGAGTTTTTATTCTTTTGTTTTAGGATTAAATATTAAAGCCATTATATATCCGAATAT
AATAGCCGCAGTTATTCCTC

Product: penicillin-binding protein, 1A family

Products: NA

Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 831; Mature: 830

Protein sequence:

>831_residues
MGKKKKKRKSSAFKIILNVFLSIFLVAGVAFGGIVFAMIKTAPPLNVQQVLTFDEPSILYDDKGQYMDKVITNEQRIVVD
YKNVPQNLKNAFVSIEDERFYKHHGVDIKRFTGVILINVTNKIKRSSKLQGASTLTQQLIKNTVLSSEVSIKRKVQEMYL
SIQLEKEISKDEILGAYMNSIFLGGNALGVEAASKQYFNKSVKDLSLIECAFIAGVPQSPSVYYPYSSVAKKNPSIYLNR
TKTVLYKMLDNGYITQNDYNKALKDLDSKKLAFAKPSAPNNKLAYEWFSIPAIEQVKKDLKTQYKYDDKQIHNLLVNGGL
KIYTTMNKNLQDKTQNTINDAYYLNSYKSNGMIYPQASAVIMDYHNGEVKTIIGGRGDQPARSYNRAASYNYLRPAGSSI
KPLTVYSAAIDSKKATSATGFEDSPIPDNIGRKYSSGAPYNPKNSPNIYSGYVNVREALKRSINVIAVKLVDRIGLNTSI
QYAEKFGIPIDQHDRSSIASLALGELHKGTNPLIMAQAYGVFGNNGTYTEAKLYTKVVDRSGKVILEPKTNTKKVLSPEA
AFITYDMLQGPVSEGGTGTQANFGNMEVRGKTGTSSDMKNLWFCGLTPYYSAAVWIGNDNSSTVDGVYSSTAARLWGDIV
KEFHVNLPYKQVQKPASVITANVDRISGKLPTQLSYRDPRGSTVYNEFFINGTIPTEYDDIHVEAQINKLTGKLASKFTP
SFLVESRVFLRRDYSPGIELLDQQWVLPYSIDEGGSLPPTEEKNNSNTRDKNKDKDKNKNKNKNKNKDKNPSQDKPNNND
NNSNNNNDNNNNAKPPENDSNQNQEDKKNKR

Sequences:

>Translated_831_residues
MGKKKKKRKSSAFKIILNVFLSIFLVAGVAFGGIVFAMIKTAPPLNVQQVLTFDEPSILYDDKGQYMDKVITNEQRIVVD
YKNVPQNLKNAFVSIEDERFYKHHGVDIKRFTGVILINVTNKIKRSSKLQGASTLTQQLIKNTVLSSEVSIKRKVQEMYL
SIQLEKEISKDEILGAYMNSIFLGGNALGVEAASKQYFNKSVKDLSLIECAFIAGVPQSPSVYYPYSSVAKKNPSIYLNR
TKTVLYKMLDNGYITQNDYNKALKDLDSKKLAFAKPSAPNNKLAYEWFSIPAIEQVKKDLKTQYKYDDKQIHNLLVNGGL
KIYTTMNKNLQDKTQNTINDAYYLNSYKSNGMIYPQASAVIMDYHNGEVKTIIGGRGDQPARSYNRAASYNYLRPAGSSI
KPLTVYSAAIDSKKATSATGFEDSPIPDNIGRKYSSGAPYNPKNSPNIYSGYVNVREALKRSINVIAVKLVDRIGLNTSI
QYAEKFGIPIDQHDRSSIASLALGELHKGTNPLIMAQAYGVFGNNGTYTEAKLYTKVVDRSGKVILEPKTNTKKVLSPEA
AFITYDMLQGPVSEGGTGTQANFGNMEVRGKTGTSSDMKNLWFCGLTPYYSAAVWIGNDNSSTVDGVYSSTAARLWGDIV
KEFHVNLPYKQVQKPASVITANVDRISGKLPTQLSYRDPRGSTVYNEFFINGTIPTEYDDIHVEAQINKLTGKLASKFTP
SFLVESRVFLRRDYSPGIELLDQQWVLPYSIDEGGSLPPTEEKNNSNTRDKNKDKDKNKNKNKNKNKDKNPSQDKPNNND
NNSNNNNDNNNNAKPPENDSNQNQEDKKNKR
>Mature_830_residues
GKKKKKRKSSAFKIILNVFLSIFLVAGVAFGGIVFAMIKTAPPLNVQQVLTFDEPSILYDDKGQYMDKVITNEQRIVVDY
KNVPQNLKNAFVSIEDERFYKHHGVDIKRFTGVILINVTNKIKRSSKLQGASTLTQQLIKNTVLSSEVSIKRKVQEMYLS
IQLEKEISKDEILGAYMNSIFLGGNALGVEAASKQYFNKSVKDLSLIECAFIAGVPQSPSVYYPYSSVAKKNPSIYLNRT
KTVLYKMLDNGYITQNDYNKALKDLDSKKLAFAKPSAPNNKLAYEWFSIPAIEQVKKDLKTQYKYDDKQIHNLLVNGGLK
IYTTMNKNLQDKTQNTINDAYYLNSYKSNGMIYPQASAVIMDYHNGEVKTIIGGRGDQPARSYNRAASYNYLRPAGSSIK
PLTVYSAAIDSKKATSATGFEDSPIPDNIGRKYSSGAPYNPKNSPNIYSGYVNVREALKRSINVIAVKLVDRIGLNTSIQ
YAEKFGIPIDQHDRSSIASLALGELHKGTNPLIMAQAYGVFGNNGTYTEAKLYTKVVDRSGKVILEPKTNTKKVLSPEAA
FITYDMLQGPVSEGGTGTQANFGNMEVRGKTGTSSDMKNLWFCGLTPYYSAAVWIGNDNSSTVDGVYSSTAARLWGDIVK
EFHVNLPYKQVQKPASVITANVDRISGKLPTQLSYRDPRGSTVYNEFFINGTIPTEYDDIHVEAQINKLTGKLASKFTPS
FLVESRVFLRRDYSPGIELLDQQWVLPYSIDEGGSLPPTEEKNNSNTRDKNKDKDKNKNKNKNKNKDKNPSQDKPNNNDN
NSNNNNDNNNNAKPPENDSNQNQEDKKNKR

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=561, Percent_Identity=30.6595365418895, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI87082258, Length=336, Percent_Identity=32.1428571428571, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788867, Length=566, Percent_Identity=23.8515901060071, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789601, Length=163, Percent_Identity=33.1288343558282, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 92796; Mature: 92665

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKKKKRKSSAFKIILNVFLSIFLVAGVAFGGIVFAMIKTAPPLNVQQVLTFDEPSILY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCEEE
DDKGQYMDKVITNEQRIVVDYKNVPQNLKNAFVSIEDERFYKHHGVDIKRFTGVILINVT
CCCHHHHHHHHCCCCEEEEECCCCCHHHHHHEEEECHHHHHHHCCCCHHHCCCEEEEEEC
NKIKRSSKLQGASTLTQQLIKNTVLSSEVSIKRKVQEMYLSIQLEKEISKDEILGAYMNS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCHHHHHHHHHHH
IFLGGNALGVEAASKQYFNKSVKDLSLIECAFIAGVPQSPSVYYPYSSVAKKNPSIYLNR
EEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHCCCCCEEEEH
TKTVLYKMLDNGYITQNDYNKALKDLDSKKLAFAKPSAPNNKLAYEWFSIPAIEQVKKDL
HHHHHHHHHCCCEEECCHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHH
KTQYKYDDKQIHNLLVNGGLKIYTTMNKNLQDKTQNTINDAYYLNSYKSNGMIYPQASAV
HHHCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCHHHEEECCCCCCEEEECCCEE
IMDYHNGEVKTIIGGRGDQPARSYNRAASYNYLRPAGSSIKPLTVYSAAIDSKKATSATG
EEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCC
FEDSPIPDNIGRKYSSGAPYNPKNSPNIYSGYVNVREALKRSINVIAVKLVDRIGLNTSI
CCCCCCCHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHEEEEEHHHHHCCCCCH
QYAEKFGIPIDQHDRSSIASLALGELHKGTNPLIMAQAYGVFGNNGTYTEAKLYTKVVDR
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCC
SGKVILEPKTNTKKVLSPEAAFITYDMLQGPVSEGGTGTQANFGNMEVRGKTGTSSDMKN
CCCEEECCCCCCCHHCCCCHHEEEHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
LWFCGLTPYYSAAVWIGNDNSSTVDGVYSSTAARLWGDIVKEFHVNLPYKQVQKPASVIT
EEEECCCHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHEE
ANVDRISGKLPTQLSYRDPRGSTVYNEFFINGTIPTEYDDIHVEAQINKLTGKLASKFTP
ECHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCH
SFLVESRVFLRRDYSPGIELLDQQWVLPYSIDEGGSLPPTEEKNNSNTRDKNKDKDKNKN
HHHHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KNKNKNKDKNPSQDKPNNNDNNSNNNNDNNNNAKPPENDSNQNQEDKKNKR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
GKKKKKRKSSAFKIILNVFLSIFLVAGVAFGGIVFAMIKTAPPLNVQQVLTFDEPSILY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCEEE
DDKGQYMDKVITNEQRIVVDYKNVPQNLKNAFVSIEDERFYKHHGVDIKRFTGVILINVT
CCCHHHHHHHHCCCCEEEEECCCCCHHHHHHEEEECHHHHHHHCCCCHHHCCCEEEEEEC
NKIKRSSKLQGASTLTQQLIKNTVLSSEVSIKRKVQEMYLSIQLEKEISKDEILGAYMNS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCHHHHHHHHHHH
IFLGGNALGVEAASKQYFNKSVKDLSLIECAFIAGVPQSPSVYYPYSSVAKKNPSIYLNR
EEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHCCCCCEEEEH
TKTVLYKMLDNGYITQNDYNKALKDLDSKKLAFAKPSAPNNKLAYEWFSIPAIEQVKKDL
HHHHHHHHHCCCEEECCHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHH
KTQYKYDDKQIHNLLVNGGLKIYTTMNKNLQDKTQNTINDAYYLNSYKSNGMIYPQASAV
HHHCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCHHHEEECCCCCCEEEECCCEE
IMDYHNGEVKTIIGGRGDQPARSYNRAASYNYLRPAGSSIKPLTVYSAAIDSKKATSATG
EEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCC
FEDSPIPDNIGRKYSSGAPYNPKNSPNIYSGYVNVREALKRSINVIAVKLVDRIGLNTSI
CCCCCCCHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHEEEEEHHHHHCCCCCH
QYAEKFGIPIDQHDRSSIASLALGELHKGTNPLIMAQAYGVFGNNGTYTEAKLYTKVVDR
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCC
SGKVILEPKTNTKKVLSPEAAFITYDMLQGPVSEGGTGTQANFGNMEVRGKTGTSSDMKN
CCCEEECCCCCCCHHCCCCHHEEEHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
LWFCGLTPYYSAAVWIGNDNSSTVDGVYSSTAARLWGDIVKEFHVNLPYKQVQKPASVIT
EEEECCCHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHEE
ANVDRISGKLPTQLSYRDPRGSTVYNEFFINGTIPTEYDDIHVEAQINKLTGKLASKFTP
ECHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCH
SFLVESRVFLRRDYSPGIELLDQQWVLPYSIDEGGSLPPTEEKNNSNTRDKNKDKDKNKN
HHHHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KNKNKNKDKNPSQDKPNNNDNNSNNNNDNNNNAKPPENDSNQNQEDKKNKR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA