Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 226950510

GI number: 226950510

Start: 3506684

End: 3507208

Strand: Direct

Name: hpt [H]

Synonym: CLM_3486

Alternate gene names: 226950510

Gene position: 3506684-3507208 (Clockwise)

Preceding gene: 226950482

Following gene: 226950512

Centisome position: 84.39

GC content: 28.38

Gene sequence:

>525_bases
ATGGAAGGAAAAAACAGAAATATATTAATAAGTAAAGAAGAAATAGAAGAAAAAATTACAGAAATTGGCGAAAAAATTTC
AAAAGATTATAAAGATAAAAACTTATACATATTATCTCTTTTAAGGGGAAGCTTCATATTTGCTGCAGATATTGTAAGAA
AAATAAACGTTCCTACAAAAATAGGATTTATGACTACTTCTAGTTATGGTCATAAAGAACAATCCTCTGGAAATGTTAAA
ATAGTAAATGATATCCCTGATGACATAAAAGGCTATGATGTTATTGTGGTAGATGATATCGTTGATACAGGGATAACTAT
GGAGTTTGTTATGAATCACATAAAATCTCTTGGTGCTAATTCTGTAAAATCCTGTGTTCTTCTTGATAAGCCTGAAAGAA
GAAAAGTAGATTTAGCCCCAGATTATTCATGCTTTACCATCCAAGATGTATTTGTTGTTGGATATGGTTTAAATTATGGA
GATTATTATAGAAATATACCTTATGTTTTTAACTGGAAAGAATAA

Upstream 100 bases:

>100_bases
ATTAGGCTTTACTCTATACCTTGACAACTTTCATATAATTTTATACTATAAAAACAATATTGTAAATATACATAATCTAT
GTATGCATTGGAGGATTATC

Downstream 100 bases:

>100_bases
TAAAAATGTAAAGCTTACAAAGCTTTACATTTTTGTTTAATCTCCACTATTTAATTTGAAGCCTGCATCTTTTAGTTTCA
TGTCAATAGCAGTATTAGGT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MEGKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKEQSSGNVK
IVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHIKSLGANSVKSCVLLDKPERRKVDLAPDYSCFTIQDVFVVGYGLNYG
DYYRNIPYVFNWKE

Sequences:

>Translated_174_residues
MEGKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKEQSSGNVK
IVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHIKSLGANSVKSCVLLDKPERRKVDLAPDYSCFTIQDVFVVGYGLNYG
DYYRNIPYVFNWKE
>Mature_174_residues
MEGKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKEQSSGNVK
IVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHIKSLGANSVKSCVLLDKPERRKVDLAPDYSCFTIQDVFVVGYGLNYG
DYYRNIPYVFNWKE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=31.3953488372093, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4504483, Length=172, Percent_Identity=29.6511627906977, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI87081689, Length=165, Percent_Identity=41.2121212121212, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=176, Percent_Identity=27.8409090909091, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19834; Mature: 19834

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTK
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCCE
IGFMTTSSYGHKEQSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHIKSLGAN
EEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
SVKSCVLLDKPERRKVDLAPDYSCFTIQDVFVVGYGLNYGDYYRNIPYVFNWKE
CCCEEEEECCCCCCEECCCCCCCEEEEEEEEEEEECCCCCHHHCCCCEEEECCC
>Mature Secondary Structure
MEGKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTK
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCCE
IGFMTTSSYGHKEQSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHIKSLGAN
EEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
SVKSCVLLDKPERRKVDLAPDYSCFTIQDVFVVGYGLNYGDYYRNIPYVFNWKE
CCCEEEEECCCCCCEECCCCCCCEEEEEEEEEEEECCCCCHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]