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The map label for this gene is hemN [H]

Identifier: 226950388

GI number: 226950388

Start: 3389398

End: 3390540

Strand: Reverse

Name: hemN [H]

Synonym: CLM_3357

Alternate gene names: 226950388

Gene position: 3390540-3389398 (Counterclockwise)

Preceding gene: 226950389

Following gene: 226950387

Centisome position: 81.6

GC content: 26.07

Gene sequence:

>1143_bases
TTGGATAGAGAGGATAAAAATAAGGAAGTTTCATTGTATATACACATACCTTTTTGTATGCAAAAATGTTCATATTGTGA
TTTTACATCTTATAGTAAAAAAGAAGATTTAATGATGGAATATGTTAAAGCCCTCTCTAAAGAAATTGTTAATAATACAA
AAAACAAGATAATAAAAACAATATTTATAGGTGGGGGTACTCCCACCTATTTATCTTTAGAGGCTTTAAATATTTTAAAA
AATACCTTAAAAACTATAGATAAAAAAGAAAATATAGAATTTACAGTAGAAGGTAATCCGGGAACTTTTACAGAGAAAAA
ACTAAAGCTACTAAAATCAATGGGAGTAAACAGATTAAGTATAGGGCTTCAAAGTTCTAAAAATAGTCTACTAAAAACAT
TAGGACGAATTCATAGTTTTGAGGATTTTGCACATAGTTTTAAAATGGCTAGAAAGGAGGGATTTAACAATATAAATGTG
GATTTAATGTTTGCTCTTCCAAATCAAAGTTTAGATGATTGGAAGGAGACTTTGCTTACAGTAGTAGGTCTAAGTCCAGA
ACATTTATCTTGTTATAGTTTAATAATTGAAGAGGGAACAAATTTTTATAATTTATATAAAAATTCATTGCTGAAACTTC
CCAAAGAAGAAGAAGAAAGAGAAATGTATGAGTATTGTATTGATTTTTTAAAAGAAAGAGGATATTTACAGTATGAAATT
TCAAATTTTGCTAATCCTAATAAAGAGTGTAGACATAATCTAGTGTATTGGGATTTGGAAGATTATATAGGTTGCGGAGT
AGGTGCTCATTCCTATGTAAATAATCAAAGATATGAAAATACTAGTTCTATAGAAACATATATAAAAGAAATAAACTCTA
ATAATCTTACTCAGATAAATTTTCATATTAATTCACAAAAAGAAAATATGGAAGAGTTTATGTTTATGGGACTTAGAAAG
ACAAAAGGTATATGTATAGATGATTTTCAGGGGAGATTTGGTAAAAATATAATACATATATATGGAAGTGTAATCAATAA
ATATAAAAAATTAAATTTATTAATAGAAAAGGAAAACAGGATATATCTATCTAAAGAGGCCGTAAGTATTTCAAATACTA
TATTTTCCGATTTTTTATTATAA

Upstream 100 bases:

>100_bases
AAAGAATGAGACAAGTTGGATCTGTAGAAGTACCACAGGAAGCATTTATGGCAGTATTAAAAACAGAGGAATAATAATAT
ATAACTTAGGAGTGTTAGGT

Downstream 100 bases:

>100_bases
GGGTTAAAAGAAAAATGAAGAAATTCTAAGAAAAAGTGAGATTTTAAAAATTTAATATAAGTTTTTTGAAAATATAAAGG
CTAAACAAAGTTAAATATCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKALSKEIVNNTKNKIIKTIFIGGGTPTYLSLEALNILK
NTLKTIDKKENIEFTVEGNPGTFTEKKLKLLKSMGVNRLSIGLQSSKNSLLKTLGRIHSFEDFAHSFKMARKEGFNNINV
DLMFALPNQSLDDWKETLLTVVGLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEEEREMYEYCIDFLKERGYLQYEI
SNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNQRYENTSSIETYIKEINSNNLTQINFHINSQKENMEEFMFMGLRK
TKGICIDDFQGRFGKNIIHIYGSVINKYKKLNLLIEKENRIYLSKEAVSISNTIFSDFLL

Sequences:

>Translated_380_residues
MDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKALSKEIVNNTKNKIIKTIFIGGGTPTYLSLEALNILK
NTLKTIDKKENIEFTVEGNPGTFTEKKLKLLKSMGVNRLSIGLQSSKNSLLKTLGRIHSFEDFAHSFKMARKEGFNNINV
DLMFALPNQSLDDWKETLLTVVGLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEEEREMYEYCIDFLKERGYLQYEI
SNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNQRYENTSSIETYIKEINSNNLTQINFHINSQKENMEEFMFMGLRK
TKGICIDDFQGRFGKNIIHIYGSVINKYKKLNLLIEKENRIYLSKEAVSISNTIFSDFLL
>Mature_380_residues
MDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKALSKEIVNNTKNKIIKTIFIGGGTPTYLSLEALNILK
NTLKTIDKKENIEFTVEGNPGTFTEKKLKLLKSMGVNRLSIGLQSSKNSLLKTLGRIHSFEDFAHSFKMARKEGFNNINV
DLMFALPNQSLDDWKETLLTVVGLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEEEREMYEYCIDFLKERGYLQYEI
SNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNQRYENTSSIETYIKEINSNNLTQINFHINSQKENMEEFMFMGLRK
TKGICIDDFQGRFGKNIIHIYGSVINKYKKLNLLIEKENRIYLSKEAVSISNTIFSDFLL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=296, Percent_Identity=32.0945945945946, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789325, Length=274, Percent_Identity=40.1459854014599, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI87082341, Length=308, Percent_Identity=26.9480519480519, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44201; Mature: 44201

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKALSKEIVNNTKNKIIKT
CCCCCCCCEEEEEEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEE
IFIGGGTPTYLSLEALNILKNTLKTIDKKENIEFTVEGNPGTFTEKKLKLLKSMGVNRLS
EEECCCCCCEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEE
IGLQSSKNSLLKTLGRIHSFEDFAHSFKMARKEGFNNINVDLMFALPNQSLDDWKETLLT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHH
VVGLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEEEREMYEYCIDFLKERGYLQYEI
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
SNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNQRYENTSSIETYIKEINSNNLTQIN
CCCCCCCHHHCCCCEEEEHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEE
FHINSQKENMEEFMFMGLRKTKGICIDDFQGRFGKNIIHIYGSVINKYKKLNLLIEKENR
EEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCE
IYLSKEAVSISNTIFSDFLL
EEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDREDKNKEVSLYIHIPFCMQKCSYCDFTSYSKKEDLMMEYVKALSKEIVNNTKNKIIKT
CCCCCCCCEEEEEEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEE
IFIGGGTPTYLSLEALNILKNTLKTIDKKENIEFTVEGNPGTFTEKKLKLLKSMGVNRLS
EEECCCCCCEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEE
IGLQSSKNSLLKTLGRIHSFEDFAHSFKMARKEGFNNINVDLMFALPNQSLDDWKETLLT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHH
VVGLSPEHLSCYSLIIEEGTNFYNLYKNSLLKLPKEEEEREMYEYCIDFLKERGYLQYEI
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
SNFANPNKECRHNLVYWDLEDYIGCGVGAHSYVNNQRYENTSSIETYIKEINSNNLTQIN
CCCCCCCHHHCCCCEEEEHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEE
FHINSQKENMEEFMFMGLRKTKGICIDDFQGRFGKNIIHIYGSVINKYKKLNLLIEKENR
EEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCE
IYLSKEAVSISNTIFSDFLL
EEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]