BacMap

Definition	Clostridium botulinum A2 str. Kyoto chromosome, complete genome.
Accession	NC_012563
Length	4,155,278

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The map label for this gene is bcrA [H]

Identifier: 226950347

GI number: 226950347

Start: 3344857

End: 3345714

Strand: Reverse

Name: bcrA [H]

Synonym: CLM_3314

Alternate gene names: 226950347

Gene position: 3345714-3344857 (Counterclockwise)

Preceding gene: 226950348

Following gene: 226950346

Centisome position: 80.52

GC content: 25.99

Gene sequence:

>858_bases
ATGAATAAAATATTAGAAGTAAAAAATTTAAAAAAAGAGTATAAAGATTTTTCAGTAGAAAATATAAGTTTTCAGTTGGA
TAGAGGATACATTATGGGGTTTATAGGGCCTAATGGGGCAGGTAAAAGTACTACCATAAAGTTAATTATGAATTTAATAA
AAAAAGATGCTGGAGATATAAAAATATTTGGCATGGATAATGTAAGATATGAAAAAGAAGTGAAGGAAAAAGTAGGCTTT
GTATATGATGAAAATTATTTTTATGACCATGTAAATATAGAAACTATGAAAAAGATAATAGCTCCTTTTTATAAAGAATG
GAGTGATGAAACTTTTAGTAAATATTTAAGAACTTTTAATTTAGATCCTAAGAAAAAAATAAAAAATCTTTCTAAGGGTA
TGAAAATGAAATTTTCATTAGCTTTAGCTCTTTCTCACAATGCGGAGCTTATAATAATGGACGAGCCTACTGCAGGATTA
GATCCTGTATTTAGAAGAGAAATCTTAGATATATTATATGATTTAATACAGGATGAAAATAAAAGTGTATTTTTTTCCAC
TCATATAACTACAGATTTAGAAAAAATAGCCGATTATATAACCTTTATAAATAAGGGGAAGTTAGTGTTTTCACAAAATA
AGGATGAGATAATGGAAAAGTATAATCTAGTAAAAGGTGGATTAGATTTTTTAAATGAAGAAACAAAAAAATATTTTGTG
GGTATAAATAAAAATTCTTTTGGTTTTGAAGGATTAACTACTTCAGCTAATATTATAAGAGAAATAACCCAAAAAGGAGA
AATTATAATAGAAAAGCCAAGTTTGGAGGATATTATGGTTTATACAGTAAGGGGGTAA

Upstream 100 bases:

>100_bases
TACATAGACTGCCGATTTGGAGTTAGTTTCTTACGCAGAGTGTTATGTATAAATGGTATGAATAGGGGAAATATCCGTAT
GAAAAAGGAGGAGATAATAT

Downstream 100 bases:

>100_bases
GAATAAATGCTAAATTTAATAAAAAAGGATTTAATTATTATTAAGTACTATATAATTAAAACTTTAGCTATTTTAGCACT
TTATATGTTTATTTTTGATA

Product: ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNKILEVKNLKKEYKDFSVENISFQLDRGYIMGFIGPNGAGKSTTIKLIMNLIKKDAGDIKIFGMDNVRYEKEVKEKVGF
VYDENYFYDHVNIETMKKIIAPFYKEWSDETFSKYLRTFNLDPKKKIKNLSKGMKMKFSLALALSHNAELIIMDEPTAGL
DPVFRREILDILYDLIQDENKSVFFSTHITTDLEKIADYITFINKGKLVFSQNKDEIMEKYNLVKGGLDFLNEETKKYFV
GINKNSFGFEGLTTSANIIREITQKGEIIIEKPSLEDIMVYTVRG

Sequences:

>Translated_285_residues
MNKILEVKNLKKEYKDFSVENISFQLDRGYIMGFIGPNGAGKSTTIKLIMNLIKKDAGDIKIFGMDNVRYEKEVKEKVGF
VYDENYFYDHVNIETMKKIIAPFYKEWSDETFSKYLRTFNLDPKKKIKNLSKGMKMKFSLALALSHNAELIIMDEPTAGL
DPVFRREILDILYDLIQDENKSVFFSTHITTDLEKIADYITFINKGKLVFSQNKDEIMEKYNLVKGGLDFLNEETKKYFV
GINKNSFGFEGLTTSANIIREITQKGEIIIEKPSLEDIMVYTVRG
>Mature_285_residues
MNKILEVKNLKKEYKDFSVENISFQLDRGYIMGFIGPNGAGKSTTIKLIMNLIKKDAGDIKIFGMDNVRYEKEVKEKVGF
VYDENYFYDHVNIETMKKIIAPFYKEWSDETFSKYLRTFNLDPKKKIKNLSKGMKMKFSLALALSHNAELIIMDEPTAGL
DPVFRREILDILYDLIQDENKSVFFSTHITTDLEKIADYITFINKGKLVFSQNKDEIMEKYNLVKGGLDFLNEETKKYFV
GINKNSFGFEGLTTSANIIREITQKGEIIIEKPSLEDIMVYTVRG

Specific function: Part of the binding-protein-dependent transport system for bacitracin that confer resistance to this antibiotic. Probably responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI45446740, Length=211, Percent_Identity=31.2796208530806, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI47078218, Length=211, Percent_Identity=31.2796208530806, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21536376, Length=214, Percent_Identity=30.8411214953271, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI27881501, Length=198, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI30795238, Length=198, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=24.7524752475248, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI153792144, Length=201, Percent_Identity=27.363184079602, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI105990541, Length=213, Percent_Identity=28.6384976525822, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI150417984, Length=216, Percent_Identity=27.3148148148148, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI27477115, Length=202, Percent_Identity=25.2475247524752, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI116734710, Length=214, Percent_Identity=25.2336448598131, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27262624, Length=225, Percent_Identity=27.1111111111111, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI27262626, Length=225, Percent_Identity=27.1111111111111, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI6005701, Length=204, Percent_Identity=24.0196078431373, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI31657092, Length=209, Percent_Identity=27.7511961722488, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI9665248, Length=213, Percent_Identity=25.3521126760563, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4505771, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI9961252, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI9961250, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786319, Length=233, Percent_Identity=33.9055793991416, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI48994943, Length=222, Percent_Identity=28.8288288288288, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87081782, Length=220, Percent_Identity=28.6363636363636, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787029, Length=218, Percent_Identity=27.9816513761468, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789672, Length=226, Percent_Identity=26.5486725663717, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788225, Length=221, Percent_Identity=28.5067873303167, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789593, Length=226, Percent_Identity=25.6637168141593, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788540, Length=196, Percent_Identity=30.1020408163265, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48995001, Length=242, Percent_Identity=27.6859504132231, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789032, Length=219, Percent_Identity=27.3972602739726, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788450, Length=276, Percent_Identity=23.5507246376812, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI48994997, Length=240, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786398, Length=227, Percent_Identity=25.9911894273128, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787105, Length=288, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081791, Length=227, Percent_Identity=23.7885462555066, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87081834, Length=206, Percent_Identity=28.1553398058252, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1786803, Length=228, Percent_Identity=22.3684210526316, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786872, Length=227, Percent_Identity=27.7533039647577, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786563, Length=226, Percent_Identity=25.6637168141593, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788897, Length=244, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789962, Length=213, Percent_Identity=23.0046948356808, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787548, Length=245, Percent_Identity=25.3061224489796, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790162, Length=237, Percent_Identity=25.3164556962025, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787792, Length=219, Percent_Identity=25.1141552511416, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787089, Length=222, Percent_Identity=23.4234234234234, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081709, Length=213, Percent_Identity=23.0046948356808, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788506, Length=205, Percent_Identity=25.8536585365854, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788644, Length=230, Percent_Identity=25.2173913043478, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790467, Length=210, Percent_Identity=23.3333333333333, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082268, Length=209, Percent_Identity=22.488038277512, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787112, Length=224, Percent_Identity=23.2142857142857, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790525, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790190, Length=233, Percent_Identity=23.175965665236, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788472, Length=221, Percent_Identity=22.6244343891403, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994883, Length=233, Percent_Identity=23.6051502145923, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=232, Percent_Identity=28.448275862069, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71983516, Length=224, Percent_Identity=29.0178571428571, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983510, Length=224, Percent_Identity=29.0178571428571, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983523, Length=224, Percent_Identity=29.0178571428571, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI115533608, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202878, Length=251, Percent_Identity=24.3027888446215, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565586, Length=196, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193208177, Length=217, Percent_Identity=26.2672811059908, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17511077, Length=226, Percent_Identity=23.8938053097345, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=231, Percent_Identity=23.3766233766234, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321081, Length=265, Percent_Identity=27.1698113207547, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221512771, Length=213, Percent_Identity=30.0469483568075, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI85725262, Length=209, Percent_Identity=29.6650717703349, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574150, Length=198, Percent_Identity=31.3131313131313, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI116007328, Length=198, Percent_Identity=31.3131313131313, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24666092, Length=210, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281362751, Length=225, Percent_Identity=29.3333333333333, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24650855, Length=220, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650853, Length=226, Percent_Identity=28.7610619469027, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24643674, Length=212, Percent_Identity=26.4150943396226, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24582014, Length=231, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24582012, Length=231, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573571, Length=215, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573573, Length=210, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221500365, Length=221, Percent_Identity=24.4343891402715, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI116007184, Length=221, Percent_Identity=24.4343891402715, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571209, Length=254, Percent_Identity=22.8346456692913, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648314, Length=214, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 33003; Mature: 33003

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILEVKNLKKEYKDFSVENISFQLDRGYIMGFIGPNGAGKSTTIKLIMNLIKKDAGDI
CCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCE
KIFGMDNVRYEKEVKEKVGFVYDENYFYDHVNIETMKKIIAPFYKEWSDETFSKYLRTFN
EEEECCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
LDPKKKIKNLSKGMKMKFSLALALSHNAELIIMDEPTAGLDPVFRREILDILYDLIQDEN
CCHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KSVFFSTHITTDLEKIADYITFINKGKLVFSQNKDEIMEKYNLVKGGLDFLNEETKKYFV
CEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEE
GINKNSFGFEGLTTSANIIREITQKGEIIIEKPSLEDIMVYTVRG
EECCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MNKILEVKNLKKEYKDFSVENISFQLDRGYIMGFIGPNGAGKSTTIKLIMNLIKKDAGDI
CCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCE
KIFGMDNVRYEKEVKEKVGFVYDENYFYDHVNIETMKKIIAPFYKEWSDETFSKYLRTFN
EEEECCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
LDPKKKIKNLSKGMKMKFSLALALSHNAELIIMDEPTAGLDPVFRREILDILYDLIQDEN
CCHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KSVFFSTHITTDLEKIADYITFINKGKLVFSQNKDEIMEKYNLVKGGLDFLNEETKKYFV
CEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEE
GINKNSFGFEGLTTSANIIREITQKGEIIIEKPSLEDIMVYTVRG
EECCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7476193 [H]