Click here to switch to the map view.

The map label for this gene is nagB [H]

Identifier: 226950242

GI number: 226950242

Start: 3219433

End: 3220167

Strand: Reverse

Name: nagB [H]

Synonym: CLM_3197

Alternate gene names: 226950242

Gene position: 3220167-3219433 (Counterclockwise)

Preceding gene: 226950243

Following gene: 226950241

Centisome position: 77.5

GC content: 28.71

Gene sequence:

>735_bases
ATGAGAATTATAGTAGTGGATAATTATGAAGAAATGAGTAAAAAAGCAGCAGCTATGATGGCTAGCCAAGTTATTTTAAA
ACCAGATAGTGTCCTTGGATTGGCAACTGGAGATACCCCTATAGGAATGTATAGAGAAATCATAAATATCTATAAAAATC
AAAAGATGGATTTCTCTAAAGTTAAAACTTTTAATTTAGATGAATACTATGGGCTAAACAGAGGAAATCCTCAGAGTTAT
TATTATTACATGATGAATAATTTATTTAATTATGTGAATATTGATAAAAATAATATTAATATTCCTAATGGAATGGCTGA
TAATATAGAAGTAGAGTGTAAGGAATATGAAAGAAAAATAGATAAAGCAGGTGGTATTGATTTACAAATTCTTGGTATCG
GTGTCAATGGTCATATTGGGTTTAATGAACCCAATATAAGTTTTGAATCAGAAACTCATCTAGTTAATCTAAATGAAAAA
ACTATAGAGTCTAATTCAAGATTTTTTAGCTCAAAAGAGGAAGTTCCAACAAAAGCTATTAGTATGGGAATTAAAAGTAT
AATACATTCAAAAAAGATAATCTTATTAGCTTGTGGTAGTGCAAAATCTGATGCTGTTTCTAAAGCTATAAATGGTAAAA
TTACCCCTAATATACCTGCATCTATTCTTCAATTACACAGAGATGTTGTTGTTATTATAGATAAGGAAGCTGCTAGCAAG
TTAAATTTGAAGTAG

Upstream 100 bases:

>100_bases
ATTGTTTATGAAAAATAAAATATTGTGACTTAGATTATTAGACACAATTAGTTATTGATTTAATAAAAGAGAAATTTAAA
TTTTAATGAGGTGTGTTTTT

Downstream 100 bases:

>100_bases
AGTAGTTTAAAATATAAGTGTTAGGAATCCATGTCCTTAAGTTATGAGGAAGAATTGCCTAACACTTTTTTAAAATTCAT
TAATATGTAAAATATACAAA

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MRIIVVDNYEEMSKKAAAMMASQVILKPDSVLGLATGDTPIGMYREIINIYKNQKMDFSKVKTFNLDEYYGLNRGNPQSY
YYYMMNNLFNYVNIDKNNINIPNGMADNIEVECKEYERKIDKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEK
TIESNSRFFSSKEEVPTKAISMGIKSIIHSKKIILLACGSAKSDAVSKAINGKITPNIPASILQLHRDVVVIIDKEAASK
LNLK

Sequences:

>Translated_244_residues
MRIIVVDNYEEMSKKAAAMMASQVILKPDSVLGLATGDTPIGMYREIINIYKNQKMDFSKVKTFNLDEYYGLNRGNPQSY
YYYMMNNLFNYVNIDKNNINIPNGMADNIEVECKEYERKIDKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEK
TIESNSRFFSSKEEVPTKAISMGIKSIIHSKKIILLACGSAKSDAVSKAINGKITPNIPASILQLHRDVVVIIDKEAASK
LNLK
>Mature_244_residues
MRIIVVDNYEEMSKKAAAMMASQVILKPDSVLGLATGDTPIGMYREIINIYKNQKMDFSKVKTFNLDEYYGLNRGNPQSY
YYYMMNNLFNYVNIDKNNINIPNGMADNIEVECKEYERKIDKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEK
TIESNSRFFSSKEEVPTKAISMGIKSIIHSKKIILLACGSAKSDAVSKAINGKITPNIPASILQLHRDVVVIIDKEAASK
LNLK

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=250, Percent_Identity=39.6, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI13027378, Length=250, Percent_Identity=38, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1786893, Length=250, Percent_Identity=36.8, Blast_Score=180, Evalue=8e-47,
Organism=Escherichia coli, GI1789530, Length=229, Percent_Identity=28.82096069869, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI48994958, Length=235, Percent_Identity=27.2340425531915, Blast_Score=100, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17554876, Length=249, Percent_Identity=39.3574297188755, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24581960, Length=250, Percent_Identity=38, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI19920764, Length=250, Percent_Identity=38, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 27276; Mature: 27276

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIVVDNYEEMSKKAAAMMASQVILKPDSVLGLATGDTPIGMYREIINIYKNQKMDFSK
CEEEEECCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VKTFNLDEYYGLNRGNPQSYYYYMMNNLFNYVNIDKNNINIPNGMADNIEVECKEYERKI
EEEECCHHHCCCCCCCCCCEEEEEHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHH
DKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEKTIESNSRFFSSKEEVPTKAI
HHCCCCEEEEEEEEECCEECCCCCCCCCCCCEEEEECCHHHHCCCCHHCCCCHHCCHHHH
SMGIKSIIHSKKIILLACGSAKSDAVSKAINGKITPNIPASILQLHRDVVVIIDKEAASK
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCC
LNLK
CCCC
>Mature Secondary Structure
MRIIVVDNYEEMSKKAAAMMASQVILKPDSVLGLATGDTPIGMYREIINIYKNQKMDFSK
CEEEEECCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VKTFNLDEYYGLNRGNPQSYYYYMMNNLFNYVNIDKNNINIPNGMADNIEVECKEYERKI
EEEECCHHHCCCCCCCCCCEEEEEHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHH
DKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEKTIESNSRFFSSKEEVPTKAI
HHCCCCEEEEEEEEECCEECCCCCCCCCCCCEEEEECCHHHHCCCCHHCCCCHHCCHHHH
SMGIKSIIHSKKIILLACGSAKSDAVSKAINGKITPNIPASILQLHRDVVVIIDKEAASK
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCC
LNLK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA