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The map label for this gene is yeiA [H]

Identifier: 226950228

GI number: 226950228

Start: 3199944

End: 3201179

Strand: Reverse

Name: yeiA [H]

Synonym: CLM_3182

Alternate gene names: 226950228

Gene position: 3201179-3199944 (Counterclockwise)

Preceding gene: 226950229

Following gene: 226950227

Centisome position: 77.04

GC content: 33.9

Gene sequence:

>1236_bases
ATGAAAAAAAGAGATCTTTCTATAGAATTTTGTGGAGTAAAGTGTGAAAATCCATTTTTCTTATCATCGTCACCAGTAGG
AAACTGTTACGAAATGTGTGCTAAAGCTTTAGAAACTGGCTGGGGGGGCATAGTGTTTAAAACAGTAGGTTTCTTTATTG
CAAATGAAGTTTCTCCACGTTTTACTAACTTAGAAAAAGAAGGTACTTCTTTTTTAGGATTTAAAAATATGGAGCAAATA
GCTGAGCATTCCTTGGAAGAAAACTTAGAAGCTATGAGAAAGTTAAAAGAAAATTATCCAAATAAAGTTTTAGTAGCTTC
AATAATGGGACAAAATGAAAAAGAGTGGGAAGAGCTTGCAAAACTTGTTACAGAAGTGGGAGCAGATATAATAGAATGTA
ACTTTTCATGTCCACAGATGACTAGTAGTGCTATGGGATCAGATGTGGGACAAAATCCACAGTTAGTTAAAAAATATTGT
GAAGCAGTAAGAAGAGGAACTGATATTCCAATACTAGCTAAAATGACTCCGAACATAGGAGATATGAGTGTGCCGGCAAT
AGCCTCTATAGAAGGTGGAGCAACAGGTATAGCTACAATAAATACAATTAAGTGCATTACAGGAGTGGACTTGGATAAAT
TTATAGGATATCCTATTGTAAATGGAAAATCATCAATTTCAGGGTACTCAGGAAAAGCAGTAAAACCAATAGCCTTAAGA
TTTATACAACAATTAGTAACAGATGAAAGGCTTAAAAATGTTCCAATAAGTGGTATAGGTGGAATAGAAACTTGGGAAGA
TGCTGCGGAATTTATATTGTTAGGATCAAGAAACTTGCAAGTAACTACTGCTGTAATGCAATATGGATATAGAATAGTAG
AAGATATGATAGAAGGTCTTTCATATTATATGAAAGAAAAAGGCTTTGAAAAATTAGAAGATATGGTGGGGTTAGCAAAT
AAAAACATAATTCCGGCAGAGGATTTAGATAGGGGATATATTGTGTACCCGAAATTTAATGAAGAAAACTGTGTAGGTTG
CGGAAGATGCTATATATCTTGCTATGATGGCGGACATCAAGCAATTAAATGGGATGGGAAAAATAGAAAACCTATATTAG
AGAAAGAAAACTGCGTAGGCTGTCATTTATGCGCTAATGTGTGTCCAGTACAATGTATATCAAAAGGAGAAATAGAGTTT
AAAAAGGATGAAATAGCTAGAGAGATAATAGTTTAA

Upstream 100 bases:

>100_bases
TTGAAGGAGATAAAACTGTTGTAAATGCTGTAAAAGAAGGAAAAGAAGCAGCAAAGGCCATAGTAAAATATCTATTATCT
AAGAAAGAAGGTGTAAGATA

Downstream 100 bases:

>100_bases
TATAAATTTGTTATCTTTTATGCCTGGTACCTTTCGTGAAAATTTAATAATTTTATAGACAGATTAAAAACCACTTATAA
TTAGTGGTTTTTAATCTGTC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKKRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALETGWGGIVFKTVGFFIANEVSPRFTNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMRKLKENYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDERLKNVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV

Sequences:

>Translated_411_residues
MKKRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALETGWGGIVFKTVGFFIANEVSPRFTNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMRKLKENYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDERLKNVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV
>Mature_411_residues
MKKRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALETGWGGIVFKTVGFFIANEVSPRFTNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMRKLKENYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDERLKNVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=323, Percent_Identity=34.984520123839, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI87082059, Length=404, Percent_Identity=72.5247524752475, Blast_Score=628, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=323, Percent_Identity=37.4613003095975, Blast_Score=204, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322633, Length=325, Percent_Identity=25.2307692307692, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24640763, Length=313, Percent_Identity=37.0607028753994, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI18858217, Length=313, Percent_Identity=37.0607028753994, Blast_Score=192, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45418; Mature: 45418

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALETGWGGIVFKTVGFFIANEVSPR
CCCCCCEEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
FTNLEKEGTSFLGFKNMEQIAEHSLEENLEAMRKLKENYPNKVLVASIMGQNEKEWEELA
HHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHH
KLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYCEAVRRGTDIPILAKMTPNIG
HHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
DMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
CCCCCCEEECCCCCCCEEEHHHHHHHCCCCHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLVTDERLKNVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGL
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
SYYMKEKGFEKLEDMVGLANKNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCC
AIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEFKKDEIAREIIV
EEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEECHHHHHHHHCC
>Mature Secondary Structure
MKKRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALETGWGGIVFKTVGFFIANEVSPR
CCCCCCEEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
FTNLEKEGTSFLGFKNMEQIAEHSLEENLEAMRKLKENYPNKVLVASIMGQNEKEWEELA
HHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHH
KLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYCEAVRRGTDIPILAKMTPNIG
HHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
DMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
CCCCCCEEECCCCCCCEEEHHHHHHHCCCCHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLVTDERLKNVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGL
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
SYYMKEKGFEKLEDMVGLANKNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCC
AIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEFKKDEIAREIIV
EEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]