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The map label for this gene is pepIP [H]

Identifier: 226949325

GI number: 226949325

Start: 2315562

End: 2316443

Strand: Direct

Name: pepIP [H]

Synonym: CLM_2246

Alternate gene names: 226949325

Gene position: 2315562-2316443 (Clockwise)

Preceding gene: 226949324

Following gene: 226949329

Centisome position: 55.73

GC content: 36.28

Gene sequence:

>882_bases
ATGAAAATTACTGAAGGCTATATGCCATATCTAGAATATAAAACTTATTATCGTATAGTAGGTGAATGTACAGGAAATAA
AAAGCCATTGGTTCTATTACACGGTGGACCGGGTTCTACGCATAATTATTTCGAAGTACTTGACAAGGTCGCAGAAGATG
GACGTGCAGTTATTATGTATGACCAATTAGGATGCGGATTATCCTCAACACCTTCTCGTCCTGACTTATGGAATGCAAAA
ACTTGGATTGAAGAATTGATTCAATTACGTAAACACTTAGGACTAGATGAAATCCATTTATTAGGACAATCCTGGGGAGG
AATGCAAGCAATTCAATATGCTTGTGAATACAAACCAGAAGGAATCAAGAGTTATATCTTATCCAGTACTTTACCAGCCG
CTTCATTATGGGAAAAGGAACAACGTAGAAGAGTTGCATACCTTCCACAAGAAATGCAAGATGCTATTGCTAAAGCAGAA
GAAGCTGGAGATTATTCCTCAAAAGAATATCAAGAAGCAGAAGCAGAATTTATGCTTCGTCACTGTGCAGGCGCAGTAGG
ACCGGATTCACCAGAATGCTTAAGACGTCCAAAAGTTGCTGGAACAGAAGCTTATGTAACTGCATGGGGTCAAAATGAAT
TTAGCCCATCTGGTACATTAAAAAACTTTGATTTTATGAAAGAAATTGAAGATATAAAGGAACCTTGTCTAATCACAAGC
GGTTTACTTGATCTTTGCTCACCACTTGTTGCAAAAACAATGTATGATAAGATTCCTAATTCAGAATGGGAATTATTTGA
ATTCAGCCGTCATATGCCATTCGTAGAAGAAAATGAAAAATATATAGAAGTACTTAATAAATGGTTAAATAAAAACGACT
AA

Upstream 100 bases:

>100_bases
TGTTCCTGAATCCAAATAAAGATAAAGAAATTGGTTAAAAATTTCTATGAAGCTTTTAACAACTAAAACTTATTACAAAA
TATAGATAAGGAGATCGATT

Downstream 100 bases:

>100_bases
TATATAAAGGCTATGAGATTACTATCTGTGATATAATCTCACGTAAATTACAAAGGAGCTGTCATGCAAATATGACAGCC
CCTTTTATTAAGTCTTTCTG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMYDQLGCGLSSTPSRPDLWNAK
TWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPEGIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAE
EAGDYSSKEYQEAEAEFMLRHCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITS
GLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND

Sequences:

>Translated_293_residues
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMYDQLGCGLSSTPSRPDLWNAK
TWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPEGIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAE
EAGDYSSKEYQEAEAEFMLRHCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITS
GLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND
>Mature_293_residues
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMYDQLGCGLSSTPSRPDLWNAK
TWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPEGIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAE
EAGDYSSKEYQEAEAEFMLRHCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITS
GLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND

Specific function: Characterized by a high specificity towards di- or tripeptides with proline at the NH(2)-terminal position, but is not able to hydrolyze longer peptides, or peptides with hydroxyproline at the NH(2)-end [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cell envelope [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 33418; Mature: 33418

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEE
DQLGCGLSSTPSRPDLWNAKTWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPE
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCC
GIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAEEAGDYSSKEYQEAEAEFMLR
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
HCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITS
HHCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEE
DQLGCGLSSTPSRPDLWNAKTWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPE
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCC
GIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAEEAGDYSSKEYQEAEAEFMLR
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
HCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITS
HHCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8012575; 8012576 [H]