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The map label for this gene is msrA [H]

Identifier: 226949222

GI number: 226949222

Start: 2193942

End: 2194415

Strand: Reverse

Name: msrA [H]

Synonym: CLM_2141

Alternate gene names: 226949222

Gene position: 2194415-2193942 (Counterclockwise)

Preceding gene: 226949223

Following gene: 226949218

Centisome position: 52.81

GC content: 30.59

Gene sequence:

>474_bases
ATGAAAGAAATAGTTTTAGCTGGAGGTTGTTTTTGGGGAGTAGAAGAATATATGTCAAGAATTGAAGGAATAGTGGAAAC
AAAAGTTGGTTATGCCAATGGAATAAAAGAAAATCCTAGTTATGAAGAGGTATGTAGTGGAGTCACAGGTCATGCAGAAG
CTTGTTACATAAAATATGATGAAAGTATTATATCCTTAGAAGAACTGTTAAATAAATTTTGGAGCATAATAGATCCAACA
GTACTAAATAAACAGGGTAACGATAGAGGAACTCAGTATAGAACATGTATATTTTACTTAGATGAAAAAGATTTAAATGT
AATTATAAAGAGTAAATATCAGGAGCAGAAAAATTATAGAAAGCCTATAGTTACTGAAGTAGAGCCCCTAAAGTGTTTTT
ATGAGGCTGAGGAGTATCATCAAAAATATTTAAAGAAAAATCCAGGAGGCTATTGTCATATACATTTAGATTAA

Upstream 100 bases:

>100_bases
AAAGTGTTTCTAAACTTAATTATGAAGTAATATATAAAGTTTAAGTAATTGCTAGTTGAAGTTATTAAGATTTCTTAAAG
AAATTATGGAGGTGTTAATT

Downstream 100 bases:

>100_bases
TTTTTATTATATGTTTTATAGGGTATGTAGGTAGATTTGTGTAAAAACAAATTTACCTACATACTCTATAAAGAGAATGT
AAATAATTTTATATATTTGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTCIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD

Sequences:

>Translated_157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTCIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
>Mature_157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTCIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=44.8051948051948, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=44.3037974683544, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=44.6428571428571, Blast_Score=97, Evalue=6e-21,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=46.6257668711656, Blast_Score=134, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=37.3239436619718, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=37.956204379562, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=36.6197183098592, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18224; Mature: 18224

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYD
CCCEEEECCHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEC
ESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTCIFYLDEKDLNVIIKSKYQEQKNYR
CHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHCC
KPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYD
CCCEEEECCHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEC
ESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTCIFYLDEKDLNVIIKSKYQEQKNYR
CHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHCC
KPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA