Click here to switch to the map view.

The map label for this gene is cloSI [H]

Identifier: 226949218

GI number: 226949218

Start: 2188225

End: 2189799

Strand: Reverse

Name: cloSI [H]

Synonym: CLM_2137

Alternate gene names: 226949218

Gene position: 2189799-2188225 (Counterclockwise)

Preceding gene: 226949222

Following gene: 226949217

Centisome position: 52.7

GC content: 29.97

Gene sequence:

>1575_bases
ATGTTAAAAAACAAGTTATCTATTCTTTTAACTTCTACTTTGGTGGCTGCTTCTCTTTTTAGTTTTAAACCTGTATATGC
AGATTCAGTGAATAATTCTAATAAAACTAATCTAAATAATGTTAGGCAGGAAATACAAAAAGCAAAAAATAATAATCAAA
AGGTAACAATTATGTATTATTGTGATGCTGATAATAATTTAGAATCATCTTTATTAAGTGACATTGAAGAAATGAAGAAA
GGATATGTTAACAATCCTAATCTAAATTTGGTGACACTTATAGATAGATCATCAAGATATACTAGTGACAAAACAGTTTT
TGGAGAAGATTTTGAAGATGCCCGCTTATATAAGATTGAACATAATAAAACTAAAAGATTAGATGGTGGAAAGGAATTTC
CTGAAATAACTCTTAATAGTAATTATGAAGCAAACATGGGGGATGCAGATACTCTTAAAAAATTCATTAATTATTGTAAA
GCTAATTATAAAGCTGATAAATATGTTTTAATAATGGCTAACCATGGTGGTGGAGCAAAAGAAAAGCTTAAAAATAATCA
AGATGTAAACAGAGCAATTTGTTGGGATGATAGTCATTATGATGGAAATAGTCCAGATTGTCTTTATATGGGAGAAATTT
CAGATACTTTAACACAGGAGCAGTCTGTTGATGTACTTGCCTTTGATGCATGCTTGATGGGAACAGCAGAGGTTGCATAT
CAATTTAGACCAGGTAATGGAGGATTTTCAGCAGATGGAATAGTTGCTTCAAGTCCTGTAGTTTGGGGACCAGGATTCCA
ATATGATAATATTTTAAGTAGATTAAAATCTGGTGGAGGAAGTAGCAATGAAGATGATTTAACTTTAGGTGGTAAAGAGA
AAAACTTTGATCCTGCAACTATTACTAATGAACAATTAGGAGCATTATTTGTAGAAGAACAAAGGGATTCTACTCATGCT
AGAGGAAGCTATGATCAACATTTGAGCTTTTATGATGCTGCTAAAGTAGAAGATGTAAAAAGATCAATAGATAATTTAGC
TATTAATTTAAGCAATGAAAATAAAAAAGATGGAATTGAAAAATTAAGAGGAAGTAAAAATAATACAAATTTAATGCACT
ATTTTGATGAATATAATGAACAAGAATGGATTGAATATCCTTATTTTGATATATATGATTTATGCGAAAAAATAAATGAA
AGTAATAATTTTAGCAATGAAACTAGAACATTGGCTTCAATCTGCATGGATAAAATAGATGAAATGGTAGTCTATTCTTT
TGGTGGCCCTAGCAAAGAATTTAAAGAAGGTAAAAATGGATTAAGTATATTCCTACCAGATGGGGATAAAAAATATTCAA
ATTATTATAATTCAATTCCTCATTGGACTATTCAAAGTTGGTATAATTCAATAGATACAGTTCAAAATGGATTACCTCCT
TATGGAAAATTAACTTGGTGCCAAGATGGACAAGATCCAAGAGTAAATAAAGTTGGAAATTGGTTCGAACTTTTAGATTC
TTGGTTTGACAAAACTAATGGAGCGGATGGAGGGGTTAACCATTATCAATGGTAA

Upstream 100 bases:

>100_bases
GTACATATTGTGCACATACATAGGGTGTTTCTATTAATATTAAATACATTATAATTCTGCATAACAAATCAAAAATATAA
AATTTGGGGGTATGTATATT

Downstream 100 bases:

>100_bases
AATACATTTTTAGCTTAATTTATTATTAAAAATACTGTCTAAAAATAGAAGTTATGCTTTCTATTTTTAGGCAGTATTTT
AATTATATTATTTTTCATTC

Product: clostripain

Products: NA

Alternate protein names: Clostridiopeptidase B [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MLKNKLSILLTSTLVAASLFSFKPVYADSVNNSNKTNLNNVRQEIQKAKNNNQKVTIMYYCDADNNLESSLLSDIEEMKK
GYVNNPNLNLVTLIDRSSRYTSDKTVFGEDFEDARLYKIEHNKTKRLDGGKEFPEITLNSNYEANMGDADTLKKFINYCK
ANYKADKYVLIMANHGGGAKEKLKNNQDVNRAICWDDSHYDGNSPDCLYMGEISDTLTQEQSVDVLAFDACLMGTAEVAY
QFRPGNGGFSADGIVASSPVVWGPGFQYDNILSRLKSGGGSSNEDDLTLGGKEKNFDPATITNEQLGALFVEEQRDSTHA
RGSYDQHLSFYDAAKVEDVKRSIDNLAINLSNENKKDGIEKLRGSKNNTNLMHYFDEYNEQEWIEYPYFDIYDLCEKINE
SNNFSNETRTLASICMDKIDEMVVYSFGGPSKEFKEGKNGLSIFLPDGDKKYSNYYNSIPHWTIQSWYNSIDTVQNGLPP
YGKLTWCQDGQDPRVNKVGNWFELLDSWFDKTNGADGGVNHYQW

Sequences:

>Translated_524_residues
MLKNKLSILLTSTLVAASLFSFKPVYADSVNNSNKTNLNNVRQEIQKAKNNNQKVTIMYYCDADNNLESSLLSDIEEMKK
GYVNNPNLNLVTLIDRSSRYTSDKTVFGEDFEDARLYKIEHNKTKRLDGGKEFPEITLNSNYEANMGDADTLKKFINYCK
ANYKADKYVLIMANHGGGAKEKLKNNQDVNRAICWDDSHYDGNSPDCLYMGEISDTLTQEQSVDVLAFDACLMGTAEVAY
QFRPGNGGFSADGIVASSPVVWGPGFQYDNILSRLKSGGGSSNEDDLTLGGKEKNFDPATITNEQLGALFVEEQRDSTHA
RGSYDQHLSFYDAAKVEDVKRSIDNLAINLSNENKKDGIEKLRGSKNNTNLMHYFDEYNEQEWIEYPYFDIYDLCEKINE
SNNFSNETRTLASICMDKIDEMVVYSFGGPSKEFKEGKNGLSIFLPDGDKKYSNYYNSIPHWTIQSWYNSIDTVQNGLPP
YGKLTWCQDGQDPRVNKVGNWFELLDSWFDKTNGADGGVNHYQW
>Mature_524_residues
MLKNKLSILLTSTLVAASLFSFKPVYADSVNNSNKTNLNNVRQEIQKAKNNNQKVTIMYYCDADNNLESSLLSDIEEMKK
GYVNNPNLNLVTLIDRSSRYTSDKTVFGEDFEDARLYKIEHNKTKRLDGGKEFPEITLNSNYEANMGDADTLKKFINYCK
ANYKADKYVLIMANHGGGAKEKLKNNQDVNRAICWDDSHYDGNSPDCLYMGEISDTLTQEQSVDVLAFDACLMGTAEVAY
QFRPGNGGFSADGIVASSPVVWGPGFQYDNILSRLKSGGGSSNEDDLTLGGKEKNFDPATITNEQLGALFVEEQRDSTHA
RGSYDQHLSFYDAAKVEDVKRSIDNLAINLSNENKKDGIEKLRGSKNNTNLMHYFDEYNEQEWIEYPYFDIYDLCEKINE
SNNFSNETRTLASICMDKIDEMVVYSFGGPSKEFKEGKNGLSIFLPDGDKKYSNYYNSIPHWTIQSWYNSIDTVQNGLPP
YGKLTWCQDGQDPRVNKVGNWFELLDSWFDKTNGADGGVNHYQW

Specific function: Cysteine endopeptidase with strict specificity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C11 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014173
- InterPro:   IPR005077 [H]

Pfam domain/function: PF03415 Peptidase_C11 [H]

EC number: =3.4.22.8 [H]

Molecular weight: Translated: 59294; Mature: 59294

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKLSILLTSTLVAASLFSFKPVYADSVNNSNKTNLNNVRQEIQKAKNNNQKVTIMYY
CCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
CDADNNLESSLLSDIEEMKKGYVNNPNLNLVTLIDRSSRYTSDKTVFGEDFEDARLYKIE
ECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEE
HNKTKRLDGGKEFPEITLNSNYEANMGDADTLKKFINYCKANYKADKYVLIMANHGGGAK
CCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
EKLKNNQDVNRAICWDDSHYDGNSPDCLYMGEISDTLTQEQSVDVLAFDACLMGTAEVAY
HHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEHHHHHCCCHHEE
QFRPGNGGFSADGIVASSPVVWGPGFQYDNILSRLKSGGGSSNEDDLTLGGKEKNFDPAT
EEECCCCCCCCCCEEECCCEEECCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCC
ITNEQLGALFVEEQRDSTHARGSYDQHLSFYDAAKVEDVKRSIDNLAINLSNENKKDGIE
CCCHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
KLRGSKNNTNLMHYFDEYNEQEWIEYPYFDIYDLCEKINESNNFSNETRTLASICMDKID
HHCCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
EMVVYSFGGPSKEFKEGKNGLSIFLPDGDKKYSNYYNSIPHWTIQSWYNSIDTVQNGLPP
HEEEEECCCCCHHHHCCCCCCEEEECCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCC
YGKLTWCQDGQDPRVNKVGNWFELLDSWFDKTNGADGGVNHYQW
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLKNKLSILLTSTLVAASLFSFKPVYADSVNNSNKTNLNNVRQEIQKAKNNNQKVTIMYY
CCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
CDADNNLESSLLSDIEEMKKGYVNNPNLNLVTLIDRSSRYTSDKTVFGEDFEDARLYKIE
ECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEE
HNKTKRLDGGKEFPEITLNSNYEANMGDADTLKKFINYCKANYKADKYVLIMANHGGGAK
CCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
EKLKNNQDVNRAICWDDSHYDGNSPDCLYMGEISDTLTQEQSVDVLAFDACLMGTAEVAY
HHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEHHHHHCCCHHEE
QFRPGNGGFSADGIVASSPVVWGPGFQYDNILSRLKSGGGSSNEDDLTLGGKEKNFDPAT
EEECCCCCCCCCCEEECCCEEECCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCC
ITNEQLGALFVEEQRDSTHARGSYDQHLSFYDAAKVEDVKRSIDNLAINLSNENKKDGIE
CCCHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
KLRGSKNNTNLMHYFDEYNEQEWIEYPYFDIYDLCEKINESNNFSNETRTLASICMDKID
HHCCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
EMVVYSFGGPSKEFKEGKNGLSIFLPDGDKKYSNYYNSIPHWTIQSWYNSIDTVQNGLPP
HEEEEECCCCCHHHHCCCCCCEEEECCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCC
YGKLTWCQDGQDPRVNKVGNWFELLDSWFDKTNGADGGVNHYQW
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8341259; 6391922; 6337850 [H]