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The map label for this gene is ispA [C]

Identifier: 226949181

GI number: 226949181

Start: 2158297

End: 2159169

Strand: Reverse

Name: ispA [C]

Synonym: CLM_2100

Alternate gene names: 226949181

Gene position: 2159169-2158297 (Counterclockwise)

Preceding gene: 226949182

Following gene: 226949180

Centisome position: 51.96

GC content: 29.9

Gene sequence:

>873_bases
ATGGATAAAATAAAAAAAATGGGGGAAGAAATAGAGTTATGGTTAAAGGAATATTTAGACAATAAAGGTAATTATGATAA
AAAGATATATGAAGCTATGGCCTATAGTTTAGAGGCTGGTGGAAAAAGAATAAGACCAGTACTATTTTTAAATACGTATA
GTTTATATAAAGAAGATTATAAAAAGGCTATGCCTATAGCTGCTGCCATAGAAATGATACATACCTATTCTTTAATACAT
GATGATCTGCCAGCTATGGATAATGATGACTTAAGGAGAGGAAAACCTACCAATCATAAAATCTTTGGAGAAGCTATAGC
TATACTGGCAGGAGATGCACTTTTAAATGAAGCTATGAATATAATGTTTGAGTATTCATTAAAAAATGGAGAAAAGGCAG
TAAAGGCGTGTTATACCATAGCTAAAGCAGCAGGAGTAGATGGGATGATTGGGGGCCAGGTAGTAGATATATTAAGTGAA
GATAAATCTATACCTCTCGATGAGTTATATTATATGCACAAAAAAAAGACCGGTGCTTTAATAAAAGCATCTATATTGGC
TGGAGCTATTTTAGGATCTGCTACATATACAGATATAGAACTTTTAGGGGAATATGGAGATAATTTAGGATTGGCATTTC
AAATAAAAGACGATATATTAGATGTGGAAGGTGATACTACTACTTTAGGAAAAAAGACAAAGAGTGATGAAGATAATCAT
AAAACTACTTTTGTTAAAGTTTATGGTATAGAGAAATGTAATGAACTTTGTACTGAAATGACAAATAAATGTTTTGATAT
ATTAAATAAAATAAAGAAAAACACAGATAAGTTAAAAGAAATTACTATGTTTTTATTAAACAGAAACTATTAA

Upstream 100 bases:

>100_bases
ACTTTGAATTAATTAAAAGAAAGTTCAGATAGAGTAATAATTTAATCTGAATTAGGATTTACTTTACAGCTAAAATTAAT
ATTAAGGATTGGTGAACTTT

Downstream 100 bases:

>100_bases
TATTAATAAAGCTTTAAATTAATTTAAATAAAAAAATAATTCTATGCAATAAATATTTTTCTGTGATATAATAGAAAATG
CTTTATACACAAAATGAATA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDKIKKMGEEIELWLKEYLDNKGNYDKKIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTYSLIH
DDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKAVKACYTIAKAAGVDGMIGGQVVDILSE
DKSIPLDELYYMHKKKTGALIKASILAGAILGSATYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSDEDNH
KTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY

Sequences:

>Translated_290_residues
MDKIKKMGEEIELWLKEYLDNKGNYDKKIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTYSLIH
DDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKAVKACYTIAKAAGVDGMIGGQVVDILSE
DKSIPLDELYYMHKKKTGALIKASILAGAILGSATYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSDEDNH
KTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
>Mature_290_residues
MDKIKKMGEEIELWLKEYLDNKGNYDKKIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTYSLIH
DDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKAVKACYTIAKAAGVDGMIGGQVVDILSE
DKSIPLDELYYMHKKKTGALIKASILAGAILGSATYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSDEDNH
KTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=217, Percent_Identity=31.7972350230415, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=40.4494382022472, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=33.0275229357798, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=215, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651612, Length=252, Percent_Identity=29.3650793650794, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32605; Mature: 32605

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIKKMGEEIELWLKEYLDNKGNYDKKIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDY
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
KKAMPIAAAIEMIHTYSLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMN
HHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IMFEYSLKNGEKAVKACYTIAKAAGVDGMIGGQVVDILSEDKSIPLDELYYMHKKKTGAL
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHH
IKASILAGAILGSATYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSDEDNH
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCCCCC
KTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKIKKMGEEIELWLKEYLDNKGNYDKKIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDY
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
KKAMPIAAAIEMIHTYSLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMN
HHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IMFEYSLKNGEKAVKACYTIAKAAGVDGMIGGQVVDILSEDKSIPLDELYYMHKKKTGAL
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHH
IKASILAGAILGSATYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSDEDNH
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCCCCC
KTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]