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The map label for this gene is ppnK [H]

Identifier: 226949177

GI number: 226949177

Start: 2153368

End: 2154213

Strand: Reverse

Name: ppnK [H]

Synonym: CLM_2096

Alternate gene names: 226949177

Gene position: 2154213-2153368 (Counterclockwise)

Preceding gene: 226949178

Following gene: 226949176

Centisome position: 51.84

GC content: 28.84

Gene sequence:

>846_bases
ATGAAAAATATTGGTATAAATATAAATACAGATAAGGATATAAGTAGAAACATTTTAGACAAAATTTTTCAGTATATACA
TGAGGAATGTAGTGAAGCTAAAATAAAGGTTTTTTATGATTCTAAAGGTTTAGATAATGAAGAAAGTAGAGCATTAGATG
CGGTAATGGTACTAGGAGGAGATGGTACTATTTTAGGTACTGCTAGAGCCTTAGCCAAATATGATGTCCCTATATTTGGA
ATAAATAGAGGGCATTTAGGGTTTTTAGCAGAGATAGAGCTAGAAGACTGTAAAGAGGCTATAAAAAATCTATTTAAAGG
TCAATATAAAATAGAGGATAGAATAATGCTAAAATGTGACTTAAAGGGAATAGACAAGAAAGATGATTTTTTAGCATTAA
ATGATATAGTGCTTACAAAAGGAAATTTATCACGAATAGTAAAATATAGCATATATGTAGATGATGTATGGTATACAACT
TTTGTAGCAGATGGAGTCATTGTAGCTACGCCTACAGGATCTACAGCCTATTCTTTATCTGCAGGAGGACCAATAGTATA
TCCAGATTTAGATGTATTAGAGATTGCGCCAATTTGTCCTCACTCTTTAGGAATTAGACCTATATTGTTAAATGGTAATA
GTAAAATTAATATAAGGGTTTTAAAGAAATATGAGGATCCTGTACTTACTATTGATGGTCAAAGATATAAAAAAGTAACA
GTAAATGAGGTTACCATAAGTAAATCTAAATATAAATGTAGACTTATAAAATTTAAAGATAAGGATTATTTTAAAATATT
AAGAACTAAAATATCTTATAGATCTAGAGAATGTGAAGGTGAATAA

Upstream 100 bases:

>100_bases
TATATATGACAAAAAATAAAGGGGTAAATAGTGATTTTCAAGATGACTATGTAGATTATATAGTAAATAAAGCTCATAAT
AATTTGAATGGTGATAAATA

Downstream 100 bases:

>100_bases
TATGAAAGTTTCAAGACATGCTAAAATTTTAGAAATAATAAATTCTAAGGATATAGATACTCAGGAGGAACTAGCAGAAG
AATTAAAGAAAATGGGGATG

Product: ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFG
INRGHLGFLAEIELEDCKEAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTT
FVADGVIVATPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVT
VNEVTISKSKYKCRLIKFKDKDYFKILRTKISYRSRECEGE

Sequences:

>Translated_281_residues
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFG
INRGHLGFLAEIELEDCKEAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTT
FVADGVIVATPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVT
VNEVTISKSKYKCRLIKFKDKDYFKILRTKISYRSRECEGE
>Mature_281_residues
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFG
INRGHLGFLAEIELEDCKEAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTT
FVADGVIVATPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVT
VNEVTISKSKYKCRLIKFKDKDYFKILRTKISYRSRECEGE

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=260, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1788968, Length=271, Percent_Identity=33.9483394833948, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320794, Length=266, Percent_Identity=31.203007518797, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325068, Length=265, Percent_Identity=32.0754716981132, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322509, Length=267, Percent_Identity=29.2134831460674, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28573828, Length=267, Percent_Identity=27.3408239700375, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573832, Length=267, Percent_Identity=27.3408239700375, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573830, Length=267, Percent_Identity=27.3408239700375, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI161077047, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573826, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI20129957, Length=311, Percent_Identity=23.7942122186495, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653422, Length=311, Percent_Identity=23.7942122186495, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363323, Length=311, Percent_Identity=23.7942122186495, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363321, Length=311, Percent_Identity=23.7942122186495, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24653424, Length=311, Percent_Identity=23.7942122186495, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 31690; Mature: 31690

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCEEEEEEECC
DGTILGTARALAKYDVPIFGINRGHLGFLAEIELEDCKEAIKNLFKGQYKIEDRIMLKCD
CCEEEEHHHHHHHCCCEEEEECCCCEEEEEEEEHHHHHHHHHHHHCCCEEECCEEEEEEE
LKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTTFVADGVIVATPTGSTAYSLS
CCCCCCCCCEEEEEEEEEECCCHHEEEEEEEEEECCEEEEEHHCCEEEEECCCCCEEEEC
AGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVT
CCCCEEECCCCCEEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEECCCCEEEEE
VNEVTISKSKYKCRLIKFKDKDYFKILRTKISYRSRECEGE
EEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCEEEEEEECC
DGTILGTARALAKYDVPIFGINRGHLGFLAEIELEDCKEAIKNLFKGQYKIEDRIMLKCD
CCEEEEHHHHHHHCCCEEEEECCCCEEEEEEEEHHHHHHHHHHHHCCCEEECCEEEEEEE
LKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTTFVADGVIVATPTGSTAYSLS
CCCCCCCCCEEEEEEEEEECCCHHEEEEEEEEEECCEEEEEHHCCEEEEECCCCCEEEEC
AGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVT
CCCCEEECCCCCEEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEECCCCEEEEE
VNEVTISKSKYKCRLIKFKDKDYFKILRTKISYRSRECEGE
EEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA