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The map label for this gene is hom [H]

Identifier: 226949173

GI number: 226949173

Start: 2148353

End: 2149579

Strand: Reverse

Name: hom [H]

Synonym: CLM_2091

Alternate gene names: 226949173

Gene position: 2149579-2148353 (Counterclockwise)

Preceding gene: 226949174

Following gene: 226949172

Centisome position: 51.73

GC content: 25.84

Gene sequence:

>1227_bases
ATGGTTTCAATTGCTATTTTGGGTAATGGAGTGGTAGGTTCAGGATTAGTAGAATTAATAGAGAGAAATAAAAAAGAGAA
TGAAGAAGAGAATATAAGTATAACCAAAATATTAGTTAGAGATAAAAATAAGCATAAAAATAACAAATTATTTTCAATAA
TTACAGAGGATATAAAAGAAGTTATAAAGGAAAATGTGAGTATTGTTGTAGAGGCTATAGGCGGAATAGAACCTGCTTAT
GATTATGTAAAAACTTTTTTGAAAAATAAAAAACATGTAGTTACTGCTAATAAAGATTTAATATCAAAACATGGTAATGA
ACTTTTAAAAATTGCAAAAGAAAATAATGTAAAGCTTTATTTTGAGGCTAGTGTAGGTGGAGGAATTCCTATACTTAGGC
CTATGAAAGAGTGCTTAGTAGGAAACAATGTGAAAAGCATTAAGGCTGTATTAAATGGTACTACAAATTTTATTTTAACT
AAAATGCATAAAGAAGGAGCTACTTTTAAAAATGCATTAGTTACTGCACAAAAATTAGGATTTGCAGAATTTGATTCTAC
ATCTGATATAAAAGGATATGATAGTGCAAGAAAGTTAGCTATATTATCGAATTTAGCCTATAATAAAAAATTTAATTGGG
AAAATTTTAATGTAGAAGGAATAGACAACATTGATAAATATGATATTGATATGGCAAATAAATTAGGAGGGGTTATTAAA
CTAATTGGAATAAGTGAAAAATTCCAAGATGGTATATATACAGCTGTTAAGCCAGCTATTATATCTAAAAATAGTATTTT
ATCAAGGGTAGAAAATGAGTTTAATTCTATAATAATAGAGGGAGACAGTATAGGAGAGGTAGCTTTCTATGGAAAAGGTG
CAGGTAAATTACCAACAGCTAGTGCAATTTATGCAGATATTATAAATATAATAAGTAATAAAAAGGAAAAAAATTTATTA
TTTAATGATGAAAAGGCTGTAATTTTTAGAGAATTTCCAAAAGAACAAGATTGGTTTATAAGAATTTCTACTGAATATAG
AACTGAAGTTATATGTGGTATAAATAAGTTATTTAAAAAAGTCTATGTATATTCAAAAAATTGTTTTTCAAATAAAGAGG
TTTTTGCTATAGTTTACAATGAAAAAGAAAAAAATTTAAAAGATAAGCTGGATAGTATACCTAATATTAAAAAATTAAGG
GCTACTATAATTTTATTCCATAGCTAA

Upstream 100 bases:

>100_bases
AGGTATAGAATACATTGGAGATATAATAAAAGATTTTAAAGAAGCATTGAGTAAAATATAAGTAAAGCGGTTTAAAGCTT
TAGATAAAGGAGGTAGAACT

Downstream 100 bases:

>100_bases
GGGCTAGTTAGCAAAGGAAATAAAATATGGCTTTAATCATAGATAAAAACCTTCCAGCTTACCAAATATTAAAATCTGAA
AATATAAATATAATGGATAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MVSIAILGNGVVGSGLVELIERNKKENEEENISITKILVRDKNKHKNNKLFSIITEDIKEVIKENVSIVVEAIGGIEPAY
DYVKTFLKNKKHVVTANKDLISKHGNELLKIAKENNVKLYFEASVGGGIPILRPMKECLVGNNVKSIKAVLNGTTNFILT
KMHKEGATFKNALVTAQKLGFAEFDSTSDIKGYDSARKLAILSNLAYNKKFNWENFNVEGIDNIDKYDIDMANKLGGVIK
LIGISEKFQDGIYTAVKPAIISKNSILSRVENEFNSIIIEGDSIGEVAFYGKGAGKLPTASAIYADIINIISNKKEKNLL
FNDEKAVIFREFPKEQDWFIRISTEYRTEVICGINKLFKKVYVYSKNCFSNKEVFAIVYNEKEKNLKDKLDSIPNIKKLR
ATIILFHS

Sequences:

>Translated_408_residues
MVSIAILGNGVVGSGLVELIERNKKENEEENISITKILVRDKNKHKNNKLFSIITEDIKEVIKENVSIVVEAIGGIEPAY
DYVKTFLKNKKHVVTANKDLISKHGNELLKIAKENNVKLYFEASVGGGIPILRPMKECLVGNNVKSIKAVLNGTTNFILT
KMHKEGATFKNALVTAQKLGFAEFDSTSDIKGYDSARKLAILSNLAYNKKFNWENFNVEGIDNIDKYDIDMANKLGGVIK
LIGISEKFQDGIYTAVKPAIISKNSILSRVENEFNSIIIEGDSIGEVAFYGKGAGKLPTASAIYADIINIISNKKEKNLL
FNDEKAVIFREFPKEQDWFIRISTEYRTEVICGINKLFKKVYVYSKNCFSNKEVFAIVYNEKEKNLKDKLDSIPNIKKLR
ATIILFHS
>Mature_408_residues
MVSIAILGNGVVGSGLVELIERNKKENEEENISITKILVRDKNKHKNNKLFSIITEDIKEVIKENVSIVVEAIGGIEPAY
DYVKTFLKNKKHVVTANKDLISKHGNELLKIAKENNVKLYFEASVGGGIPILRPMKECLVGNNVKSIKAVLNGTTNFILT
KMHKEGATFKNALVTAQKLGFAEFDSTSDIKGYDSARKLAILSNLAYNKKFNWENFNVEGIDNIDKYDIDMANKLGGVIK
LIGISEKFQDGIYTAVKPAIISKNSILSRVENEFNSIIIEGDSIGEVAFYGKGAGKLPTASAIYADIINIISNKKEKNLL
FNDEKAVIFREFPKEQDWFIRISTEYRTEVICGINKLFKKVYVYSKNCFSNKEVFAIVYNEKEKNLKDKLDSIPNIKKLR
ATIILFHS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=261, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45789; Mature: 45789

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSIAILGNGVVGSGLVELIERNKKENEEENISITKILVRDKNKHKNNKLFSIITEDIKE
CEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHH
VIKENVSIVVEAIGGIEPAYDYVKTFLKNKKHVVTANKDLISKHGNELLKIAKENNVKLY
HHHHHHHEEHHHHCCCCHHHHHHHHHHCCCCEEEECCHHHHHHCCHHHHHHEECCCEEEE
FEASVGGGIPILRPMKECLVGNNVKSIKAVLNGTTNFILTKMHKEGATFKNALVTAQKLG
EEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEHHCCCHHHHHHHHHHHCC
FAEFDSTSDIKGYDSARKLAILSNLAYNKKFNWENFNVEGIDNIDKYDIDMANKLGGVIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEE
LIGISEKFQDGIYTAVKPAIISKNSILSRVENEFNSIIIEGDSIGEVAFYGKGAGKLPTA
EEECCHHHHCCCHHHHCHHHHCHHHHHHHHHHHHCEEEEECCCCCCEEEECCCCCCCCCH
SAIYADIINIISNKKEKNLLFNDEKAVIFREFPKEQDWFIRISTEYRTEVICGINKLFKK
HHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHH
VYVYSKNCFSNKEVFAIVYNEKEKNLKDKLDSIPNIKKLRATIILFHS
HHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHEEEEEEEEEC
>Mature Secondary Structure
MVSIAILGNGVVGSGLVELIERNKKENEEENISITKILVRDKNKHKNNKLFSIITEDIKE
CEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHH
VIKENVSIVVEAIGGIEPAYDYVKTFLKNKKHVVTANKDLISKHGNELLKIAKENNVKLY
HHHHHHHEEHHHHCCCCHHHHHHHHHHCCCCEEEECCHHHHHHCCHHHHHHEECCCEEEE
FEASVGGGIPILRPMKECLVGNNVKSIKAVLNGTTNFILTKMHKEGATFKNALVTAQKLG
EEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEHHCCCHHHHHHHHHHHCC
FAEFDSTSDIKGYDSARKLAILSNLAYNKKFNWENFNVEGIDNIDKYDIDMANKLGGVIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEE
LIGISEKFQDGIYTAVKPAIISKNSILSRVENEFNSIIIEGDSIGEVAFYGKGAGKLPTA
EEECCHHHHCCCHHHHCHHHHCHHHHHHHHHHHHCEEEEECCCCCCEEEECCCCCCCCCH
SAIYADIINIISNKKEKNLLFNDEKAVIFREFPKEQDWFIRISTEYRTEVICGINKLFKK
HHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHH
VYVYSKNCFSNKEVFAIVYNEKEKNLKDKLDSIPNIKKLRATIILFHS
HHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]