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The map label for this gene is thrB [H]

Identifier: 226948966

GI number: 226948966

Start: 1923114

End: 1924007

Strand: Direct

Name: thrB [H]

Synonym: CLM_1880

Alternate gene names: 226948966

Gene position: 1923114-1924007 (Clockwise)

Preceding gene: 226948965

Following gene: 226948967

Centisome position: 46.28

GC content: 33.33

Gene sequence:

>894_bases
ATGGTAGAAGTTAGAGTGCCTGCTACAAGTGCAAATATAGGACCAGGATTTGATTGTTTAGGTGTAGCAGTAAATATATA
TAATAAATTCTTTGTAGAAGAAATTGAAGAGGGACTTATTTTTGAAGGTTGCGCGGATAAATTTAAAAATGAGAACAACT
TAATATATGTGGCTATGAAAAAGTGTTTTGATAAAATCGGATACAAACCTACAGGATTAAGGATAAAAATAGAAAGTGAT
ATACCTGTCTCACGTGGGCTTGGAAGTAGTGCAGCCTGTGTGGTAGGAGGTATAGTTTCTGCCAATGAATTAGCTGGTGG
AGTTTTAAATAAAAAAGAACTTTTAGATTTAGCAGTGGGAGTGGAAGGGCATCCGGACAATGTAAATCCAGCTTTTTGTG
GGGGAATGACTGCTTCCATATCTGATAATAGAGAAGTAATTTATAGTAAAGTGAAGGTGAGTGAAGGTATTAAGTTTTGT
GCACTTATACCAGATTTTACTTTATCTACAGAAAAGGCAAGGGCAGTCCTTCCTAAAAGTATAGATTACAAAGATGGAAT
TTTTAATGTAGGAAGAACCGCACTTATGATATCTGCATTAAATAATGGTGATTTTCATTTAATAAAATATGCTTGCAAGG
ATAAATTACATCAGGACTATAGAGCAAAGCTTATAGAAAATTTTTATTCAATAAAGGAAGAGTGTGAAAAACTAAATTCT
TTAGGTGTATTTTTAAGTGGGGCAGGACCAACAATTATGGTGATGCTTAAAGAAGAGGACAAGCGTTTTTCAAAAAATAT
TAAAAGTTTTTTAGAGACTTTAAAGAACAAGTGGGAAGTTAGGGAACTTAAGATAGACAAGCTTGGAACTGTAGTAAATA
ATCGTAAGGTTTAA

Upstream 100 bases:

>100_bases
AGAAGGACTAGAGGAAAGAGAAATTTGTCATAAGGGCACTTGTAAAAAGGATGAAATGAAGAAAGTAATTAAAAATTTTT
TAGGAATATAGGTGATTAAA

Downstream 100 bases:

>100_bases
ATTGAATAAGTTTAAGTAAATTATTAAGTTTAAAAAATTAGATAGTTTAGAGTAAGAAATGAAAGGATCTTTAATATATT
GATTACTGTGAATTATTAAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MVEVRVPATSANIGPGFDCLGVAVNIYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMKKCFDKIGYKPTGLRIKIESD
IPVSRGLGSSAACVVGGIVSANELAGGVLNKKELLDLAVGVEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFC
ALIPDFTLSTEKARAVLPKSIDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKEECEKLNS
LGVFLSGAGPTIMVMLKEEDKRFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNRKV

Sequences:

>Translated_297_residues
MVEVRVPATSANIGPGFDCLGVAVNIYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMKKCFDKIGYKPTGLRIKIESD
IPVSRGLGSSAACVVGGIVSANELAGGVLNKKELLDLAVGVEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFC
ALIPDFTLSTEKARAVLPKSIDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKEECEKLNS
LGVFLSGAGPTIMVMLKEEDKRFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNRKV
>Mature_297_residues
MVEVRVPATSANIGPGFDCLGVAVNIYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMKKCFDKIGYKPTGLRIKIESD
IPVSRGLGSSAACVVGGIVSANELAGGVLNKKELLDLAVGVEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFC
ALIPDFTLSTEKARAVLPKSIDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKEECEKLNS
LGVFLSGAGPTIMVMLKEEDKRFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNRKV

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=271, Percent_Identity=30.9963099630996, Blast_Score=114, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=350, Percent_Identity=30.5714285714286, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32704; Mature: 32704

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVRVPATSANIGPGFDCLGVAVNIYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMK
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCEEEEEHH
KCFDKIGYKPTGLRIKIESDIPVSRGLGSSAACVVGGIVSANELAGGVLNKKELLDLAVG
HHHHHHCCCCCCEEEEECCCCCHHCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHC
VEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFCALIPDFTLSTEKARAVLPKS
CCCCCCCCCCHHHCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCC
IDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKEECEKLNS
CCCCCCHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVFLSGAGPTIMVMLKEEDKRFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNRKV
CEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHEEHHHHHHHHCCCCC
>Mature Secondary Structure
MVEVRVPATSANIGPGFDCLGVAVNIYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMK
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCEEEEEHH
KCFDKIGYKPTGLRIKIESDIPVSRGLGSSAACVVGGIVSANELAGGVLNKKELLDLAVG
HHHHHHCCCCCCEEEEECCCCCHHCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHC
VEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFCALIPDFTLSTEKARAVLPKS
CCCCCCCCCCHHHCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCC
IDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKEECEKLNS
CCCCCCHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVFLSGAGPTIMVMLKEEDKRFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNRKV
CEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA