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The map label for this gene is thrC [H]

Identifier: 226948965

GI number: 226948965

Start: 1921623

End: 1923104

Strand: Direct

Name: thrC [H]

Synonym: CLM_1879

Alternate gene names: 226948965

Gene position: 1921623-1923104 (Clockwise)

Preceding gene: 226948964

Following gene: 226948966

Centisome position: 46.25

GC content: 29.69

Gene sequence:

>1482_bases
TTGTTTTATAAAAGTACTAGAGGAGAAGGAAAGAATGTTAAAGCATCAGAGGCAATAATTAGAGGAATAGCTGAGGATGG
AGGATTATATGTACCAGAAGAGCTTCCTAAAATAGATAAGAGCTTTAAAGAACTAGAAAACATGGATTATAAAGAATTAG
CATTTTATATTATGAAAAAGTACTTTGATGATTTTAATGAAGAGGAACTTAAAGAATGTATAGATAGAGCCTATGACAGT
AAGTTTGAAGATCCTCTTATAGCGACATTAAATTATAAAGCTGGAGCATATTTTTTAGAACTTTATCATGGGAAAACATT
AGCCTTTAAAGATATGGCCTTAAGCATACTTCCACACCTTTTAAAAGCTTCAGCAAAAAAGATTAATATAACTAAAGACA
TAGTTATATTAACAGCTACTTCAGGAGATACTGGAAAAGCTGCTCTAGAAGGATTTGATAGTGTAGAGGGCACAAAGATA
GTAGTGTTTTATCCTAAGGATGGAGTAAGTGAAATTCAAAAAAGACAAATGGTTACACAAGAGGGGAAAAATACTTTTGT
AGTTGGTATAGAGGGGAATTTCGATGATGCTCAAAGTGGAGTTAAGGAAATATTTAATGATAAAGATTTTAATGAATTAT
TAGAGGAAAAGGGATGCATGTTTTCCTCTGCTAATTCTATAAATATAGGGAGATTGGTACCGCAAATAGTATATTATGTT
TATTCTTATGTAAACCTACTTAAAGACAAAAAAGTAGGGGAAGGAGAAAGTATAAACATAGTTGTTCCTACAGGAAATTT
TGGTAACATTTTAGCAGCCTTTTACGCTAAAAATATGGGAATACCAGTGGAAAAATTAATTTGTGCATCTAATGAGAATA
AGGTGCTAACAGACTTTATAAATACTGGAATATACGATAGGAGAAGAAAATTTTCTGTTACTAATTCTCCTTCTATGGAT
ATTTTAATATCCAGTAACTTGGAAAGATTTTTGTATGAAATAAGTGGAAAAGATTCATGCCTTATAAAAAATCTCATGAC
AGAACTTAAAGAAAAGGGTAAATATGAGATAACAGAGGAAATGAAGAAGAGATTAGATATATTATATGGAGATTTTTCAG
ATGAAGATGATACACTTAAAGCTATTGCAAAAGTCTATGAAAGTTCTAATTATCTTATAGATACTCATACTGCAGTAGCT
TATGATGTTTATGAAAAATATAAAAATAGAACAGAAGATAATAGGGTTACTATTATAGCATCCACTGCAAGTCCATTCAA
ATTTCCTAAAAGTATAAATGAAGTGTTAAATATAGGACATAAGAATGCCTCAGATTTTGAACTTATTAATTTATTTTCAG
ATAAATTAAATTTAAAGTTGCCTAAAGGATTAGAAGGACTAGAGGAAAGAGAAATTTGTCATAAGGGCACTTGTAAAAAG
GATGAAATGAAGAAAGTAATTAAAAATTTTTTAGGAATATAG

Upstream 100 bases:

>100_bases
GACGGAATAATATATATATTATAACTTTAACAGAAGAGGAAAAAATAGAAAATGGAATAAAACATATAAAAATATATTTC
ATTAAAAGGGGGCTAATAAT

Downstream 100 bases:

>100_bases
GTGATTAAAATGGTAGAAGTTAGAGTGCCTGCTACAAGTGCAAATATAGGACCAGGATTTGATTGTTTAGGTGTAGCAGT
AAATATATATAATAAATTCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELENMDYKELAFYIMKKYFDDFNEEELKECIDRAYDS
KFEDPLIATLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKASAKKINITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIEGNFDDAQSGVKEIFNDKDFNELLEEKGCMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGESINIVVPTGNFGNILAAFYAKNMGIPVEKLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSCLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIAKVYESSNYLIDTHTAVA
YDVYEKYKNRTEDNRVTIIASTASPFKFPKSINEVLNIGHKNASDFELINLFSDKLNLKLPKGLEGLEEREICHKGTCKK
DEMKKVIKNFLGI

Sequences:

>Translated_493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELENMDYKELAFYIMKKYFDDFNEEELKECIDRAYDS
KFEDPLIATLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKASAKKINITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIEGNFDDAQSGVKEIFNDKDFNELLEEKGCMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGESINIVVPTGNFGNILAAFYAKNMGIPVEKLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSCLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIAKVYESSNYLIDTHTAVA
YDVYEKYKNRTEDNRVTIIASTASPFKFPKSINEVLNIGHKNASDFELINLFSDKLNLKLPKGLEGLEEREICHKGTCKK
DEMKKVIKNFLGI
>Mature_493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELENMDYKELAFYIMKKYFDDFNEEELKECIDRAYDS
KFEDPLIATLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKASAKKINITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIEGNFDDAQSGVKEIFNDKDFNELLEEKGCMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGESINIVVPTGNFGNILAAFYAKNMGIPVEKLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSCLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIAKVYESSNYLIDTHTAVA
YDVYEKYKNRTEDNRVTIIASTASPFKFPKSINEVLNIGHKNASDFELINLFSDKLNLKLPKGLEGLEEREICHKGTCKK
DEMKKVIKNFLGI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=471, Percent_Identity=41.4012738853503, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI149193323, Length=440, Percent_Identity=30.4545454545455, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786185, Length=428, Percent_Identity=28.7383177570093, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319901, Length=475, Percent_Identity=36, Blast_Score=282, Evalue=8e-77,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55804; Mature: 55804

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELENMDYKELAFYIMKK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YFDDFNEEELKECIDRAYDSKFEDPLIATLNYKAGAYFLELYHGKTLAFKDMALSILPHL
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCEEHHHHHHHHHHHHH
LKASAKKINITKDIVILTATSGDTGKAALEGFDSVEGTKIVVFYPKDGVSEIQKRQMVTQ
HHCCCCEEEEEEEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EGKNTFVVGIEGNFDDAQSGVKEIFNDKDFNELLEEKGCMFSSANSINIGRLVPQIVYYV
CCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
YSYVNLLKDKKVGEGESINIVVPTGNFGNILAAFYAKNMGIPVEKLICASNENKVLTDFI
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHH
NTGIYDRRRKFSVTNSPSMDILISSNLERFLYEISGKDSCLIKNLMTELKEKGKYEITEE
HCCHHHCHHCEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
MKKRLDILYGDFSDEDDTLKAIAKVYESSNYLIDTHTAVAYDVYEKYKNRTEDNRVTIIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEE
STASPFKFPKSINEVLNIGHKNASDFELINLFSDKLNLKLPKGLEGLEEREICHKGTCKK
ECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCHHHHHHHHCCCCCH
DEMKKVIKNFLGI
HHHHHHHHHHHCC
>Mature Secondary Structure
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELENMDYKELAFYIMKK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YFDDFNEEELKECIDRAYDSKFEDPLIATLNYKAGAYFLELYHGKTLAFKDMALSILPHL
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCEEHHHHHHHHHHHHH
LKASAKKINITKDIVILTATSGDTGKAALEGFDSVEGTKIVVFYPKDGVSEIQKRQMVTQ
HHCCCCEEEEEEEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EGKNTFVVGIEGNFDDAQSGVKEIFNDKDFNELLEEKGCMFSSANSINIGRLVPQIVYYV
CCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
YSYVNLLKDKKVGEGESINIVVPTGNFGNILAAFYAKNMGIPVEKLICASNENKVLTDFI
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHH
NTGIYDRRRKFSVTNSPSMDILISSNLERFLYEISGKDSCLIKNLMTELKEKGKYEITEE
HCCHHHCHHCEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
MKKRLDILYGDFSDEDDTLKAIAKVYESSNYLIDTHTAVAYDVYEKYKNRTEDNRVTIIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEE
STASPFKFPKSINEVLNIGHKNASDFELINLFSDKLNLKLPKGLEGLEEREICHKGTCKK
ECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCHHHHHHHHCCCCCH
DEMKKVIKNFLGI
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]