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The map label for this gene is cdr [H]

Identifier: 226948911

GI number: 226948911

Start: 1850147

End: 1851847

Strand: Direct

Name: cdr [H]

Synonym: CLM_1821

Alternate gene names: 226948911

Gene position: 1850147-1851847 (Clockwise)

Preceding gene: 226948910

Following gene: 226948912

Centisome position: 44.53

GC content: 31.28

Gene sequence:

>1701_bases
ATGAGCAAAAAATATTTAATAATAGGAGGAGTTGCTGGTGGTGCATCTACCGCAGCTAGACTTAGAAGACTTAGTGAGGA
AGATCAAATAATAATGTTTGAAAAAGATCCCTATGTATCCTTTTCAAATTGTAGCTTACCTTATCATTTGAGTGGGGTTG
TAGAGGATTCCAATAGTTTAGTACTTATGACTCCAGAACAATTTAAAGCTCAATACAATATAGAGGCTAGAGTAAATAAT
GAAGTTATAACAATTAATAGAGATAAAAAAGAAGTTATAGTTAAAAATACATTAACAGGAGAAAAGTATTCTGAAAATTA
TGATAAATTAATCTTATCCCCAGGAGCAACGCCAATAGTTCCACCAATTAAAGGTATTGAAAATGTAAATGTATTTACAG
TAAGAAATGTAATGGATATACAGAGATTAAGTGAAAAATTAAAAAATAAAAAATTTCAAAACATATCTGTTATTGGAGGA
GGTTTTATAGGGGTTGAAGTTGCTGAAAATTTAAAAGAAGCAGGAAACGATGTTACTTTAATTGAAGCTATGCCTCATAT
CATGAAACCCTTTGATTATGATATGGCACAGATTTTACACAAAGAATTTTATGATAATGGTGTAAATTTAATTGTAAAAG
ATAAGGTTAGTGCTTTTGAAAAAGACACAGTAGTTTTAGAATCTGGAAGAAAAGTACAGGCTGAGGCTGTGATTATGGCC
ATAGGTGTAGCTCCAGATACAAGACTCGCAAAGGCGGCAGGATTAGAAATTGGAGAAACTGGAGCTATAAAAGTAGATCA
AAATTATAGAACTAGTGATAATGATATATATGCAGTAGGAGATGCTATTGAAGTTTATCATGCTCTAGCTAGAAAAACTA
CTAAACTACCTTTAGCAGGACCTGCTCAAAAAGAAGCAAGACAGGTGGCAGATCATATTCATGGAAGAGTTGTTAGGAAT
ACAGGCTTTATAGGAAGTTCAGTAATTAAATGTTTCGATTATAATGCAGCAGCCACAGGACTTAATGAAGAAATGATAGA
AGCATTAAAATTAGACATAAAATATGAGGTGGCTAAGGTGATACCGGGAGATAAGGTAGGATTAATGCCAGATTGTGAGC
CTCTACATTTTAAATTAATTTTCGAAATTCCTACAGGGAAAGTATTAGGAGCACAAGCTATTGGTAAAGGAAATGTAGAT
AAGAGAATAGATGTAATTGCTACAGCAATTAAATTTGGAGCTACTGTAGATGATCTAAGAGACTTAGAATTATGCTATGC
ACCACCTTTTGGAACTGCTAAAGATGTAGTAAATTTTGCAGGCTATGTAGCATGTAATTTATTACAGGATGAATTTAGAC
AAGTTAGAGAAAAAGATATAAGAAATATCGTAAAAGAAAAAGCTTTAATTATAGATGTAAGAGAGAAGCATGAATATGAA
TTAAGTCATATTATTGGTGCAAAAAATATACCTCTTAGTGAGTTAAGAGATAGAATAAATGAAATACCTGAAGATGAGCC
TGTGTATTTACACTGTAGAAGTGCTCAAAGAAGTTATAACGCATTAAAGGCTCTTAAAAATTTAGGTTATGAAAATATTT
ATAACGTTTCTGGTGGATTTTTAGGAATTTCTTTTTATGAATACTTTAATGACATAACTACTAAAAGAGAAAAAATTCTT
ACAGATTATAACTTTTTATAA

Upstream 100 bases:

>100_bases
AAAATTATAAAATTAAGTAATCAATAAGTTTTATTTATAAATACAGCCATTATAAGGGGCTTAATACCTTGTACAATATA
TTTTAATGGAGGTATAAATT

Downstream 100 bases:

>100_bases
AATTAGAAATTGAGTAATCTAGCTTATTTAAATAACTATAAGGATTCTATGGTTCAAAAGGAGCTTTTATCTCAATTGAA
CCATAGCAATTCTTAACTAG

Product: pyridine nucleotide-disulfide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNN
EVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIQRLSEKLKNKKFQNISVIGG
GFIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVIMA
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDNDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRN
TGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVD
KRIDVIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
LSHIIGAKNIPLSELRDRINEIPEDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKIL
TDYNFL

Sequences:

>Translated_566_residues
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNN
EVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIQRLSEKLKNKKFQNISVIGG
GFIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVIMA
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDNDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRN
TGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVD
KRIDVIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
LSHIIGAKNIPLSELRDRINEIPEDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKIL
TDYNFL
>Mature_565_residues
SKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNNE
VITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIQRLSEKLKNKKFQNISVIGGG
FIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVIMAI
GVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDNDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRNT
GFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDK
RIDVIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYEL
SHIIGAKNIPLSELRDRINEIPEDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKILT
DYNFL

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=291, Percent_Identity=29.2096219931272, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI21389617, Length=291, Percent_Identity=29.2096219931272, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI65787454, Length=291, Percent_Identity=29.2096219931272, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=26.875, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788892, Length=283, Percent_Identity=27.208480565371, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789765, Length=296, Percent_Identity=26.6891891891892, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786307, Length=329, Percent_Identity=27.355623100304, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639257, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281359715, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281359713, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639250, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI18543267, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639252, Length=322, Percent_Identity=21.7391304347826, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585130, Length=297, Percent_Identity=21.5488215488215, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 62990; Mature: 62859

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSL
CCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEEEECCCCE
VLMTPEQFKAQYNIEARVNNEVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIV
EEECHHHHCEEEEEEEEECCEEEEEECCCCEEEEEECCCCCHHCCCCCEEEECCCCCCCC
PPIKGIENVNVFTVRNVMDIQRLSEKLKNKKFQNISVIGGGFIGVEVAENLKEAGNDVTL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEE
IEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVIMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCEEEEECCCEEEEEEEEEE
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDNDIYAVGDAIEVYHALARKTTKLPLAG
EECCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCC
PAQKEARQVADHIHGRVVRNTGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKV
CCHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHCCEEEEEEC
IPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDKRIDVIATAIKFGATVDDLR
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHH
LSHIIGAKNIPLSELRDRINEIPEDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGF
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCE
LGISFYEYFNDITTKREKILTDYNFL
EEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSL
CCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEEEECCCCE
VLMTPEQFKAQYNIEARVNNEVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIV
EEECHHHHCEEEEEEEEECCEEEEEECCCCEEEEEECCCCCHHCCCCCEEEECCCCCCCC
PPIKGIENVNVFTVRNVMDIQRLSEKLKNKKFQNISVIGGGFIGVEVAENLKEAGNDVTL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEE
IEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVIMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCEEEEECCCEEEEEEEEEE
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDNDIYAVGDAIEVYHALARKTTKLPLAG
EECCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCC
PAQKEARQVADHIHGRVVRNTGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKV
CCHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHCCEEEEEEC
IPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDKRIDVIATAIKFGATVDDLR
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHH
LSHIIGAKNIPLSELRDRINEIPEDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGF
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCE
LGISFYEYFNDITTKREKILTDYNFL
EEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA